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MeSH Review

Clathrin-Coated Vesicles

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Disease relevance of Clathrin-Coated Vesicles


High impact information on Clathrin-Coated Vesicles


Biological context of Clathrin-Coated Vesicles


Anatomical context of Clathrin-Coated Vesicles


Associations of Clathrin-Coated Vesicles with chemical compounds

  • In the past year, examples of phosphoinositide effectors include regulators of small GTPases in coat assembly, dynamin in clathrin coated vesicle formation and FYVE finger proteins in endocytic membrane traffic [18].
  • RNAi-mediated CPG2 knockdown increases the number of postsynaptic clathrin-coated vesicles, some of which traffic NMDA receptors, disrupts the constitutive internalization of glutamate receptors, and inhibits the activity-induced internalization of synaptic AMPA receptors [19].
  • Hub expression blocked lysosomal delivery of chimeric molecules containing either the tyrosine-based sorting signal of H2M or the dileucine-based sorting signal of CD3gamma, confirming a role for clathrin-coated vesicles (CCVs) in recognizing these signals and sorting them to the endocytic pathway [20].
  • In the principal cell vesicle recycling is induced by a specific hormone, vasopressin, and involves clathrin-coated vesicles in the endocytotic step of the cycle [21].
  • Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN [22].

Gene context of Clathrin-Coated Vesicles


Analytical, diagnostic and therapeutic context of Clathrin-Coated Vesicles


  1. Transport of the membrane glycoprotein of vesicular stomatitis virus to the cell surface in two stages by clathrin-coated vesicles. Rothman, J.E., Bursztyn-Pettegrew, H., Fine, R.E. J. Cell Biol. (1980) [Pubmed]
  2. Cystic fibrosis transmembrane conductance regulator protein expression in brain. Mulberg, A.E., Wiedner, E.B., Bao, X., Marshall, J., Jefferson, D.M., Altschuler, S.M. Neuroreport (1994) [Pubmed]
  3. A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis. Mao, Y., Chen, J., Maynard, J.A., Zhang, B., Quiocho, F.A. Cell (2001) [Pubmed]
  4. The binding of AP-1 clathrin adaptor particles to Golgi membranes requires ADP-ribosylation factor, a small GTP-binding protein. Stamnes, M.A., Rothman, J.E. Cell (1993) [Pubmed]
  5. Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Soubeyran, P., Kowanetz, K., Szymkiewicz, I., Langdon, W.Y., Dikic, I. Nature (2002) [Pubmed]
  6. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Chen, H., Fre, S., Slepnev, V.I., Capua, M.R., Takei, K., Butler, M.H., Di Fiore, P.P., De Camilli, P. Nature (1998) [Pubmed]
  7. Regulation of receptor-mediated endocytosis by Rho and Rac. Lamaze, C., Chuang, T.H., Terlecky, L.J., Bokoch, G.M., Schmid, S.L. Nature (1996) [Pubmed]
  8. Uncoating of clathrin-coated vesicles in presynaptic terminals: roles for Hsc70 and auxilin. Morgan, J.R., Prasad, K., Jin, S., Augustine, G.J., Lafer, E.M. Neuron (2001) [Pubmed]
  9. Synergistic activation of dynamin GTPase by Grb2 and phosphoinositides. Barylko, B., Binns, D., Lin, K.M., Atkinson, M.A., Jameson, D.M., Yin, H.L., Albanesi, J.P. J. Biol. Chem. (1998) [Pubmed]
  10. Dopamine acutely stimulates Na+/H+ exchanger (NHE3) endocytosis via clathrin-coated vesicles: dependence on protein kinase A-mediated NHE3 phosphorylation. Hu, M.C., Fan, L., Crowder, L.A., Karim-Jimenez, Z., Murer, H., Moe, O.W. J. Biol. Chem. (2001) [Pubmed]
  11. Clathrin-coated pit-associated proteins are required for alveolar macrophage phagocytosis. Perry, D.G., Daugherty, G.L., Martin, W.J. J. Immunol. (1999) [Pubmed]
  12. The aftiphilin/p200/gamma-synergin complex. Hirst, J., Borner, G.H., Harbour, M., Robinson, M.S. Mol. Biol. Cell (2005) [Pubmed]
  13. Antibodies to clathrin inhibit endocytosis but not recycling to the trans Golgi network in vitro. Draper, R.K., Goda, Y., Brodsky, F.M., Pfeffer, S.R. Science (1990) [Pubmed]
  14. Coupling actin dynamics and membrane dynamics during endocytosis. Schafer, D.A. Curr. Opin. Cell Biol. (2002) [Pubmed]
  15. Acidic vesicles in cultured rat hepatocytes. Identification and characterization of their relationship to lysosomes and other storage vesicles. Lake, J.R., Van Dyke, R.W., Scharschmidt, B.F. Gastroenterology (1987) [Pubmed]
  16. Endocytosis of glycophospholipid-anchored and transmembrane forms of CD4 by different endocytic pathways. Keller, G.A., Siegel, M.W., Caras, I.W. EMBO J. (1992) [Pubmed]
  17. Mammalian GGAs act together to sort mannose 6-phosphate receptors. Ghosh, P., Griffith, J., Geuze, H.J., Kornfeld, S. J. Cell Biol. (2003) [Pubmed]
  18. Phosphoinositides in membrane traffic. Corvera, S., D'Arrigo, A., Stenmark, H. Curr. Opin. Cell Biol. (1999) [Pubmed]
  19. CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors. Cottrell, J.R., Borok, E., Horvath, T.L., Nedivi, E. Neuron (2004) [Pubmed]
  20. A dominant-negative clathrin mutant differentially affects trafficking of molecules with distinct sorting motifs in the class II major histocompatibility complex (MHC) pathway. Liu, S.H., Marks, M.S., Brodsky, F.M. J. Cell Biol. (1998) [Pubmed]
  21. Vesicle recycling and cell-specific function in kidney epithelial cells. Brown, D. Annu. Rev. Physiol. (1989) [Pubmed]
  22. Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN. Le Borgne, R., Hoflack, B. J. Cell Biol. (1997) [Pubmed]
  23. Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution. Wakeham, D.E., Abi-Rached, L., Towler, M.C., Wilbur, J.D., Parham, P., Brodsky, F.M. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  24. Further demonstration of the diversity of chromosomal changes involving 2p23 in ALK-positive lymphoma: 2 cases expressing ALK kinase fused to CLTCL (clathrin chain polypeptide-like). Touriol, C., Greenland, C., Lamant, L., Pulford, K., Bernard, F., Rousset, T., Mason, D.Y., Delsol, G. Blood (2000) [Pubmed]
  25. Clint: a novel clathrin-binding ENTH-domain protein at the Golgi. Kalthoff, C., Groos, S., Kohl, R., Mahrhold, S., Ungewickell, E.J. Mol. Biol. Cell (2002) [Pubmed]
  26. Huntingtin interacting protein 1 (HIP1) regulates clathrin assembly through direct binding to the regulatory region of the clathrin light chain. Legendre-Guillemin, V., Metzler, M., Lemaire, J.F., Philie, J., Gan, L., Hayden, M.R., McPherson, P.S. J. Biol. Chem. (2005) [Pubmed]
  27. Neuronal leucine-rich repeat protein-3 amplifies MAPK activation by epidermal growth factor through a carboxyl-terminal region containing endocytosis motifs. Fukamachi, K., Matsuoka, Y., Ohno, H., Hamaguchi, T., Tsuda, H. J. Biol. Chem. (2002) [Pubmed]
  28. Evidence for ADP-ribosylation factor (ARF) as a regulator of in vitro endosome-endosome fusion. Lenhard, J.M., Kahn, R.A., Stahl, P.D. J. Biol. Chem. (1992) [Pubmed]
  29. Biologically active, recombinant DNA in clathrin-coated vesicles isolated from rat livers after in vivo injection of liposome-encapsulated DNA. Nandi, P.K., Legrand, A., Nicolau, C. J. Biol. Chem. (1986) [Pubmed]
  30. Phosphorylation of the cytoplasmic domain of the bovine cation-independent mannose 6-phosphate receptor. Serines 2421 and 2492 are the targets of a casein kinase II associated to the Golgi-derived HAI adaptor complex. Méresse, S., Ludwig, T., Frank, R., Hoflack, B. J. Biol. Chem. (1990) [Pubmed]
  31. Isolation of a protein activator of the clathrin-coated vesicle proton pump. Xie, X.S., Crider, B.P., Stone, D.K. J. Biol. Chem. (1993) [Pubmed]
  32. Neural cell adhesion molecule is endocytosed via a clathrin-dependent pathway. Miñana, R., Duran, J.M., Tomas, M., Renau-Piqueras, J., Guerri, C. Eur. J. Neurosci. (2001) [Pubmed]
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