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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Progesterone metabolism by the filamentous fungus Cochliobolus lunatus.

Studies of Cochliobolus lunatus m118 steroid metabolism by thin-layer chromatography, mass spectrometry and NMR spectroscopy revealed that the fungus hydroxylates progesterone at positions 7 alpha, 11 beta and 14 alpha, and oxidizes the 11 beta-hydroxy group to the ketone. The 1H NMR spectra of two of the steroid metabolites, 11 beta,14 alpha-dihydroxyprogesterone and 11-oxo-14 alpha-hydroxyprogesterone, are reported for the first time. It is still not known if all the hydroxylation reactions are performed in C. lunatus by a single, non-specific, steroid hydroxylase, structurally different from the 11 beta-hydroxylase found in higher eucaryotes, or if different forms of the enzyme are involved.[1]

References

  1. Progesterone metabolism by the filamentous fungus Cochliobolus lunatus. Vita, M., Smith, K., Rozman, D., Komel, R. J. Steroid Biochem. Mol. Biol. (1994) [Pubmed]
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