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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Platelet function in acute leukemias.

Bleeding time, clot retraction, platelet factor 3 availability and platelet aggregation in response to ADP, epinephrine, collagen and ristocetin were studied in 13 cases of acute leukemia which included 5 cases of acute myeloid leukemia, 2 of chronic myeloid leukemia in blast crisis and 6 of acute lymphoblastic leukemia. More than one abnormality was seen in all the patients. Defects in bleeding time, clot retraction and platelet factor 3 availability were encountered in 43% of cases. Platelet aggregation responses to all the reagents were significantly impaired. There was, however, no consistency in the pattern of the defects.[1]


  1. Platelet function in acute leukemias. Naresh, K.N., Sivasankaran, P., Veliath, A.J. The Journal of the Association of Physicians of India. (1993) [Pubmed]
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