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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Bleeding Time

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Disease relevance of Bleeding Time


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Chemical compound and disease context of Bleeding Time


Biological context of Bleeding Time


Anatomical context of Bleeding Time


Associations of Bleeding Time with chemical compounds


Gene context of Bleeding Time


Analytical, diagnostic and therapeutic context of Bleeding Time


  1. Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia. Mannucci, P.M., Remuzzi, G., Pusineri, F., Lombardi, R., Valsecchi, C., Mecca, G., Zimmerman, T.S. N. Engl. J. Med. (1983) [Pubmed]
  2. Conjugated estrogens for the management of bleeding associated with renal failure. Livio, M., Mannucci, P.M., Viganò, G., Mingardi, G., Lombardi, R., Mecca, G., Remuzzi, G. N. Engl. J. Med. (1986) [Pubmed]
  3. Role of thrombin signalling in platelets in haemostasis and thrombosis. Sambrano, G.R., Weiss, E.J., Zheng, Y.W., Huang, W., Coughlin, S.R. Nature (2001) [Pubmed]
  4. Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. Fabre, J.E., Nguyen, M., Latour, A., Keifer, J.A., Audoly, L.P., Coffman, T.M., Koller, B.H. Nat. Med. (1999) [Pubmed]
  5. Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease. Wu, Q., Yu, D., Post, J., Halks-Miller, M., Sadler, J.E., Morser, J. J. Clin. Invest. (1998) [Pubmed]
  6. Hemostatic, inflammatory, and fibroblast responses are blunted in mice lacking gelsolin. Witke, W., Sharpe, A.H., Hartwig, J.H., Azuma, T., Stossel, T.P., Kwiatkowski, D.J. Cell (1995) [Pubmed]
  7. Improvement of renal function with selective thromboxane antagonism in lupus nephritis. Pierucci, A., Simonetti, B.M., Pecci, G., Mavrikakis, G., Feriozzi, S., Cinotti, G.A., Patrignani, P., Ciabattoni, G., Patrono, C. N. Engl. J. Med. (1989) [Pubmed]
  8. Prostacyclin-like activity and bleeding in renal failure. Remuzzi, G., Cavenaghi, A.E., Mecca, G., Donati, M.B., de Gaetano, G. Lancet (1977) [Pubmed]
  9. Desamino-D-arginine vasopressin and bleeding time in von Willebrand's disease. Isola, L., Forster, A., Aledort, L.M. Ann. Intern. Med. (1984) [Pubmed]
  10. Correlation between template bleeding times and spontaneous bleeding during treatment of acute myocardial infarction with recombinant tissue-type plasminogen activator. Gimple, L.W., Gold, H.K., Leinbach, R.C., Coller, B.S., Werner, W., Yasuda, T., Johns, J.A., Ziskind, A.A., Finkelstein, D., Collen, D. Circulation (1989) [Pubmed]
  11. Patients with a prolonged bleeding time and normal aggregation tests may have storage pool deficiency: studies on one hundred six patients. Nieuwenhuis, H.K., Akkerman, J.W., Sixma, J.J. Blood (1987) [Pubmed]
  12. Shear stress activation of platelet glycoprotein IIb/IIIa plus von Willebrand factor causes aggregation: filter blockage and the long bleeding time in von Willebrand's disease. O'Brien, J.R., Salmon, G.P. Blood (1987) [Pubmed]
  13. Inhibition of platelet thrombus formation by chlorpromazine acting to diminish haemolysis. Born, G.V., Wehmeier, A. Nature (1979) [Pubmed]
  14. Preservation of hemostatic and structural properties of rehydrated lyophilized platelets: potential for long-term storage of dried platelets for transfusion. Read, M.S., Reddick, R.L., Bode, A.P., Bellinger, D.A., Nichols, T.C., Taylor, K., Smith, S.V., McMahon, D.K., Griggs, T.R., Brinkhous, K.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  15. Studies of thromboxane B2, platelet factor 4, and fibrinopeptide A in bleeding-time blood of patients deficient in von Willebrand factor, platelet glycoproteins Ib and IIb-IIIa, and storage granules. Weiss, H.J., Lages, B. Blood (1993) [Pubmed]
  16. Heterogeneous phenotypes of platelet and plasma von Willebrand factor in obligatory heterozygotes for severe von Willebrand disease. Mannucci, P.M., Lattuada, A., Castaman, G., Lombardi, R., Colibretti, M.L., Ciavarella, N., Rodeghiero, F. Blood (1989) [Pubmed]
  17. The effect of desmopressin on massive gastrointestinal bleeding in hereditary telangiectasia unresponsive to treatment with cryoprecipitate. Quitt, M., Froom, P., Veisler, A., Falber, V., Sova, J., Aghai, E. Arch. Intern. Med. (1990) [Pubmed]
  18. Effects of desmopressin acetate on platelet aggregation, von Willebrand factor, and blood loss after cardiac surgery with extracorporeal circulation. Andersson, T.L., Solem, J.O., Tengborn, L., Vinge, E. Circulation (1990) [Pubmed]
  19. Relationship between the anticoagulant and antithrombotic effects of heparin in experimental venous thrombosis. Chiu, H.M., Hirsh, J., Yung, W.L., Regoeczi, E., Gent, M. Blood (1977) [Pubmed]
  20. Subunit composition of plasma von Willebrand factor in patients with the myeloproliferative syndrome. Budde, U., Dent, J.A., Berkowitz, S.D., Ruggeri, Z.M., Zimmerman, T.S. Blood (1986) [Pubmed]
  21. Factor VIII ectopically expressed in platelets: efficacy in hemophilia A treatment. Yarovoi, H.V., Kufrin, D., Eslin, D.E., Thornton, M.A., Haberichter, S.L., Shi, Q., Zhu, H., Camire, R., Fakharzadeh, S.S., Kowalska, M.A., Wilcox, D.A., Sachais, B.S., Montgomery, R.R., Poncz, M. Blood (2003) [Pubmed]
  22. Critical role of beta3 integrin in experimental postmenopausal osteoporosis. Zhao, H., Kitaura, H., Sands, M.S., Ross, F.P., Teitelbaum, S.L., Novack, D.V. J. Bone Miner. Res. (2005) [Pubmed]
  23. Ethanol potentiation of aspirin-induced prolongation of the bleeding time. Deykin, D., Janson, P., McMahon, L. N. Engl. J. Med. (1982) [Pubmed]
  24. Prolonged bleeding time associated with 'low-dose' moxalactam therapy. Bach, M.C. JAMA (1984) [Pubmed]
  25. Effect on platelet function of cilostazol, clopidogrel, and aspirin, each alone or in combination. Comerota, A.J. Atherosclerosis. Supplements. (2005) [Pubmed]
  26. Antihemophilic factor concentrate therapy in von Willebrand disease. Dissociation of bleeding-time factor and ristocetin-cofactor activities. Blatt, P.M., Brinkhous, K.M., Culp, H.R., Krauss, J.S., Roberts, H.R. JAMA (1976) [Pubmed]
  27. Interleukin 11 significantly increases plasma von Willebrand factor and factor VIII in wild type and von Willebrand disease mouse models. Denis, C.V., Kwack, K., Saffaripour, S., Maganti, S., André, P., Schaub, R.G., Wagner, D.D. Blood (2001) [Pubmed]
  28. Protection against thrombosis in mice lacking PAR3. Weiss, E.J., Hamilton, J.R., Lease, K.E., Coughlin, S.R. Blood (2002) [Pubmed]
  29. Genetic and pharmacological analyses of Syk function in alphaIIbbeta3 signaling in platelets. Law, D.A., Nannizzi-Alaimo, L., Ministri, K., Hughes, P.E., Forsyth, J., Turner, M., Shattil, S.J., Ginsberg, M.H., Tybulewicz, V.L., Phillips, D.R. Blood (1999) [Pubmed]
  30. The regulation of platelet-dense granules by Rab27a in the ashen mouse, a model of Hermansky-Pudlak and Griscelli syndromes, is granule-specific and dependent on genetic background. Novak, E.K., Gautam, R., Reddington, M., Collinson, L.M., Copeland, N.G., Jenkins, N.A., McGarry, M.P., Swank, R.T. Blood (2002) [Pubmed]
  31. Bleeding time prolongation with streptokinase and its reduction with 1-desamino-8-D-arginine vasopressin. Johnstone, M.T., Andrews, T., Ware, J.A., Rudd, M.A., George, D., Weinstein, M., Loscalzo, J. Circulation (1990) [Pubmed]
  32. Comparative immunogenicity and thrombolytic properties toward arterial and venous thrombi of streptokinase and recombinant staphylokinase in baboons. Collen, D., De Cock, F., Stassen, J.M. Circulation (1993) [Pubmed]
  33. Does desmopressin acetate reduce blood loss after surgery in patients on cardiopulmonary bypass? Rocha, E., Llorens, R., Páramo, J.A., Arcas, R., Cuesta, B., Trenor, A.M. Circulation (1988) [Pubmed]
  34. A hereditary bleeding disorder of dogs caused by a lack of platelet procoagulant activity. Brooks, M.B., Catalfamo, J.L., Brown, H.A., Ivanova, P., Lovaglio, J. Blood (2002) [Pubmed]
  35. Platelet storage pool deficiency associated with inherited abnormalities of the inner ear in the mouse pigment mutants muted and mocha. Swank, R.T., Reddington, M., Howlett, O., Novak, E.K. Blood (1991) [Pubmed]
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