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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Direct and indirect blood pressure in normotensive and hypertensive subjects.

OBJECTIVES. To compare intrabrachial blood pressure (I-BP) with simultaneously measured contralateral auscultatory (A-)BP in hypertensive and normotensive subjects. The question was whether differences between direct and indirect BP are influenced by the BP levels. SUBJECTS. Hypertensive subjects treated with either placebo (n = 10) or metoprolol (n = 8) and age-matched normotensive subjects (n = 15), selected from a defined patient population waiting for cholecystectomy or hernia repair. Measurements were performed pre-induction of anaesthesia. RESULTS. In the hypertensive subjects, cuff systolic BP ( SBP) was lower than I-BP by an average of 8 mmHg (placebo-) and 7 mmHg (metoprolol-treated), whereas diastolic A-BP (A-DBP) was 3 and 7 mmHg higher, respectively. In the normotensive subjects, mean A- SBP and I- SBP agreed closely, whereas A-DBP was 11 mmHg higher. Thus, SBP differences (i.e. indirect-direct BP) were significantly less and DBP differences significantly greater in the normotensive than in the hypertensive subjects (P < 0.05). Plasma renin activity and adrenalin showed better correlations with A-MBP than with I-MBP. CONCLUSIONS. The drift of cuff systolic readings fell progressively below the intrabrachial values when BP increased, whilst diastolic cuff values approached the direct pressures. Since A-MBP did not significantly differ from I-MBP in any group, one must ask whether hypertension would be more correctly defined according to MBP criteria.[1]

References

  1. Direct and indirect blood pressure in normotensive and hypertensive subjects. Fagher, B., Magnússon, J., Thulin, T. J. Intern. Med. (1994) [Pubmed]
 
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