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McGuire, T.C. et al.

Recombinant vaccinia virus expression of Anaplasma marginale surface protein MSP-1a: effect of promoters, leader sequences and GPI anchor sequence on antibody response.

Anaplasma marginale surface protein MSP-1a was expressed by recombinant vaccinia viruses with different promoters and as hybrid proteins. Transcription of msp1 alpha with P11 late promoter resulted in more MSP-1a than with P7.5 early-late promoter; however, mice immunized with the recombinants had similar antibody titres. Recombinants expressing hybrid MSP-1a with either a murine leukaemia virus or a trypanosomal glycoprotein signal sequence did not enhance antibody responses and resulted in a diffuse intracellular distribution of MSP-1a which did not accumulate in the Golgi apparatus as was noted in the absence of these signal sequences. In contrast, antibody titres to MSP-1a in mice immunized with a recombinant virus expressing hybrid MSP-1a with a trypanosomal GPI anchor signal sequence were significantly increased over all other constructs.[1]

References

Recombinant vaccinia virus expression of Anaplasma marginale surface protein MSP-1a: effect of promoters, leader sequences and GPI anchor sequence on antibody response. McGuire, T.C., Stephens, E.B., Palmer, G.H., McElwain, T.F., Lichtensteiger, C.A., Leib, S.R., Barbet, A.F. Vaccine (1994) [Pubmed]

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