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Gene Review

Glg1  -  golgi apparatus protein 1

Mus musculus

Synonyms: AI593353, AW537898, CFR, CFR-1, E-selectin ligand 1, ...
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Disease relevance of Glg1


High impact information on Glg1


Chemical compound and disease context of Glg1


Biological context of Glg1


Anatomical context of Glg1

  • As a consequence, in the innervated fiber, the GA exists both as an evenly distributed organelle with basic functions, and as a highly differentiated subsynaptic organelle ensuring maturation and targeting of synaptic proteins [18].
  • These data show that in innervated muscle fibers, the distal part of the biosynthetic pathway, i.e., the GA, is remodeled selectively shortly after the onset of innervation [18].
  • In innervated adult skeletal muscles, the Golgi apparatus (GA) displays a set of remarkable features in comparison with embryonic myotubes [18].
  • P-selectin glycoprotein ligand-1 (PSGL-1) has been the only E-selectin ligand demonstrated to function during the in vivo migration of activated T cells [19].
  • However, when the terminal Arg1171 or up to nine distal amino acids were deleted, the protein was distributed to the plasma membrane and filopodia as well as the Golgi apparatus [20].

Associations of Glg1 with chemical compounds


Physical interactions of Glg1


Regulatory relationships of Glg1


Other interactions of Glg1


Analytical, diagnostic and therapeutic context of Glg1


  1. The E-selectin-ligand ESL-1 is located in the Golgi as well as on microvilli on the cell surface. Steegmaier, M., Borges, E., Berger, J., Schwarz, H., Vestweber, D. J. Cell. Sci. (1997) [Pubmed]
  2. O-linked oligosaccharides are acquired by herpes simplex virus glycoproteins in the Golgi apparatus. Johnson, D.C., Spear, P.G. Cell (1983) [Pubmed]
  3. Intracellular transport of the transmembrane glycoprotein G of vesicular stomatitis virus through the Golgi apparatus as visualized by electron microscope radioautography. Bergeron, J.J., Kotwal, G.J., Levine, G., Bilan, P., Rachubinski, R., Hamilton, M., Shore, G.C., Ghosh, H.P. J. Cell Biol. (1982) [Pubmed]
  4. A down-regulatable E-selectin ligand is functionally important for PSGL-1-independent leukocyte-endothelial cell interactions. Zanardo, R.C., Bonder, C.S., Hwang, J.M., Andonegui, G., Liu, L., Vestweber, D., Zbytnuik, L., Kubes, P. Blood (2004) [Pubmed]
  5. Structural changes in murine cancer associated with hyperthermia and lidocaine. Clark, A.W., Robins, H.I., Vorpahl, J.W., Yatvin, M.B. Cancer Res. (1983) [Pubmed]
  6. Targeted disruption of mouse conventional kinesin heavy chain, kif5B, results in abnormal perinuclear clustering of mitochondria. Tanaka, Y., Kanai, Y., Okada, Y., Nonaka, S., Takeda, S., Harada, A., Hirokawa, N. Cell (1998) [Pubmed]
  7. Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Lippincott-Schwartz, J., Yuan, L.C., Bonifacino, J.S., Klausner, R.D. Cell (1989) [Pubmed]
  8. Vesicles and cisternae in the trans Golgi apparatus of human fibroblasts are acidic compartments. Anderson, R.G., Pathak, R.K. Cell (1985) [Pubmed]
  9. Had-1, a uridine 5'-diphosphogalactose transport-defective mutant of mouse mammary tumor cell FM3A: composition of glycolipids, cell growth inhibition by lactosylceramide, and loss of tumorigenicity. Taki, T., Ogura, K., Rokukawa, C., Hara, T., Kawakita, M., Endo, T., Kobata, A., Handa, S. Cancer Res. (1991) [Pubmed]
  10. Alterations of cell surface carbohydrates and inhibition of metastatic property of murine melanomas by alpha 1,3 galactosyltransferase gene transfection. Gorelik, E., Duty, L., Anaraki, F., Galili, U. Cancer Res. (1995) [Pubmed]
  11. Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains. Nagaya, H., Wada, I., Jia, Y.J., Kanoh, H. Mol. Biol. Cell (2002) [Pubmed]
  12. Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched preparation from cultures of mouse mastocytoma cells. Silbert, J.E., Freilich, L.S. Biochem. J. (1980) [Pubmed]
  13. Role of SA-Le(a) and E-selectin in metastasis assessed with peptide antagonist. O, I., Otvos, L., Kieber-Emmons, T., Blaszczyk-Thurin, M. Peptides (2002) [Pubmed]
  14. Structure of the murine E-selectin ligand 1 (ESL-1) gene and assignment to Chromosome 8. Willmroth, F., Beaudet, A.L. Mamm. Genome (1999) [Pubmed]
  15. Regulation of Cdc42-mediated morphological effects: a novel function for p53. Gadéa, G., Lapasset, L., Gauthier-Rouvière, C., Roux, P. EMBO J. (2002) [Pubmed]
  16. Endocytosis of cholera toxin in GERL-like structures of murine neuroblastoma cells pretreated with GM1 ganglioside. Cholera toxin internalization into Neuroblastoma GERL. Joseph, K.C., Stieber, A., Gonatas, N.K. J. Cell Biol. (1979) [Pubmed]
  17. Functional requirements for fukutin-related protein in the Golgi apparatus. Esapa, C.T., Benson, M.A., Schröder, J.E., Martin-Rendon, E., Brockington, M., Brown, S.C., Muntoni, F., Kröger, S., Blake, D.J. Hum. Mol. Genet. (2002) [Pubmed]
  18. Developmental regulation of membrane traffic organization during synaptogenesis in mouse diaphragm muscle. Antony, C., Huchet, M., Changeux, J.P., Cartaud, J. J. Cell Biol. (1995) [Pubmed]
  19. CD43 Collaborates with P-Selectin Glycoprotein Ligand-1 to Mediate E-Selectin-Dependent T Cell Migration into Inflamed Skin. Matsumoto, M., Shigeta, A., Furukawa, Y., Tanaka, T., Miyasaka, M., Hirata, T. J. Immunol. (2007) [Pubmed]
  20. Truncations of the C-terminal cytoplasmic domain of MG160, a medial Golgi sialoglycoprotein, result in its partial transport to the plasma membrane and filopodia. Gonatas, J.O., Chen, Y.J., Stieber, A., Mourelatos, Z., Gonatas, N.K. J. Cell. Sci. (1998) [Pubmed]
  21. Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells. Hornef, M.W., Normark, B.H., Vandewalle, A., Normark, S. J. Exp. Med. (2003) [Pubmed]
  22. Biosynthesis and membrane topography of the neural cell adhesion molecule L1. Faissner, A., Teplow, D.B., Kübler, D., Keilhauer, G., Kinzel, V., Schachner, M. EMBO J. (1985) [Pubmed]
  23. Golgi apparatus, GERL, and secretory granule formation within neurons of the hypothalamo-neurohypophysial system of control and hyperosmotically stressed mice. Broadwell, R.D., Oliver, C. J. Cell Biol. (1981) [Pubmed]
  24. Immunocytochemical localization of eight protein kinase C isozymes overexpressed in NIH 3T3 fibroblasts. Isoform-specific association with microfilaments, Golgi, endoplasmic reticulum, and nuclear and cell membranes. Goodnight, J.A., Mischak, H., Kolch, W., Mushinski, J.F. J. Biol. Chem. (1995) [Pubmed]
  25. Dynamin II regulates hormone secretion in neuroendocrine cells. Yang, Z., Li, H., Chai, Z., Fullerton, M.J., Cao, Y., Toh, B.H., Funder, J.W., Liu, J.P. J. Biol. Chem. (2001) [Pubmed]
  26. Characterization of VIP36, an animal lectin homologous to leguminous lectins. Fiedler, K., Simons, K. J. Cell. Sci. (1996) [Pubmed]
  27. Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse. Izumi, T., Yokota-Hashimoto, H., Zhao, S., Wang, J., Halban, P.A., Takeuchi, T. Diabetes (2003) [Pubmed]
  28. P-selectin glycoprotein ligand-1 and E-selectin ligand-1 are differentially modified by fucosyltransferases Fuc-TIV and Fuc-TVII in mouse neutrophils. Huang, M.C., Zöllner, O., Moll, T., Maly, P., Thall, A.D., Lowe, J.B., Vestweber, D. J. Biol. Chem. (2000) [Pubmed]
  29. TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3. Perry, E., Tsruya, R., Levitsky, P., Pomp, O., Taller, M., Weisberg, S., Parris, W., Kulkarni, S., Malovani, H., Pawson, T., Shpungin, S., Nir, U. Oncogene (2004) [Pubmed]
  30. Budding from Golgi membranes requires the coatomer complex of non-clathrin coat proteins. Orci, L., Palmer, D.J., Ravazzola, M., Perrelet, A., Amherdt, M., Rothman, J.E. Nature (1993) [Pubmed]
  31. ADP-ribosylation factor is functionally and physically associated with the Golgi complex. Stearns, T., Willingham, M.C., Botstein, D., Kahn, R.A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  32. Expression of truncated forms of the bovine growth hormone gene in cultured mouse cells. McAndrew, S.J., Chen, N.Y., Wiehl, P., DiCaprio, L., Yun, J., Wagner, T.E., Okada, S., Kopchick, J.J. J. Biol. Chem. (1991) [Pubmed]
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