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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Transfection of the bcr/abl oncogene into factor-dependent cells by electroporation: acquisition of autonomous proliferation.

In order to clarify the function of P210 bcr/abl oncogene in leukemogenesis, IL-3 dependent murine hematopietic cell line, FDC-P2, was transfected with the plasmid containing cDNA of P210 bcr/abl oncogene (pGD'210) or murine IL-3 (pcDmIL3) by electroporation. Four out of five pGDH210 transfected clones as well as FDC-P2 transfected with pcDmIL3, acquired autonomous proliferation (i.e. lost the requirement for IL-3 supplementation). The expression of bcr/abl oncogene was weak in one clone, which remained dependent on IL-3. Unlike pcDmIL3 transfectants, which secrete IL-3 into the supernatant, IL-3 was not demonstrated in the culture supernatant of pGD'210 transfected FDC-P2. These finding suggest that P210 bcr/abl oncogene is directly associated with autonomous proliferation, which is the first process of leukemogenesis.[1]

References

  1. Transfection of the bcr/abl oncogene into factor-dependent cells by electroporation: acquisition of autonomous proliferation. Takahashi, M., Furukawa, T., Tanaka, I., Ohsawa, Y., Nikkuni, K., Oaki, A., Goto, T., Hashimoto, T., Kishi, K., Koike, T. Hematological oncology. (1994) [Pubmed]
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