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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Activation of the alternative (properdin) pathway by divalent cations.

Mg++, Mn++ and Co++ activate the C system as judged by the reduction in cobra venom factor indeed hemolysis, and cleavage of properdin factor B and C3. The maximum effect requires the addition of 5 to 10 mM of these cations to dialyzed sera respond in similar fashion indicating that these divalent cations can trigger the alternative pathway without the addition other activating agents.[1]


  1. Activation of the alternative (properdin) pathway by divalent cations. Lew, F.T., Yukiyama, Y., Waks, H.S., Osler, A.G. J. Immunol. (1975) [Pubmed]
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