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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Secretion of a fibronectin-like substance from head and neck carcinomas.

The secretion of a fibronectin-like substance in culture supernatants of cell lines of head and neck squamous cell carcinomas was observed. Culture supernatants of some tumor cells had a high cell-attachment activity. Enzyme-linked immunosorbent assay with an antifibronectin antibody showed that the supernatant with cell attachment activity contained fibronectin. Furthermore, the cell attachment activity was clearly inhibited by the addition of a monoclonal antibody to fibronectin. These findings strongly suggest that the fibronectin produced by cancer cells is one of the potent mediators of the cell attachment.[1]


  1. Secretion of a fibronectin-like substance from head and neck carcinomas. Sakumoto, M., Tsukuda, M., Mochimatsu, I., Yago, T., Kokatsu, T. ORL J. Otorhinolaryngol. Relat. Spec. (1994) [Pubmed]
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