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Gene Review

FNL1  -  fibronectin-like 1

Homo sapiens

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Disease relevance of FNL1


High impact information on FNL1


Biological context of FNL1


Anatomical context of FNL1


Associations of FNL1 with chemical compounds


Physical interactions of FNL1

  • Most interestingly, we show that the anomalous lateral diffusion and, consequently, the binding to gelatin is greatly facilitated by the C-terminal hemopexin-like domain of the enzyme whereas the specificity of binding resides with the fibronectin-like gelatin-binding domain [22].

Regulatory relationships of FNL1

  • This is the first direct biochemical demonstration of a fibronectin-like molecule in the sea urchin embryo which cross reacts with antibodies to vertebrate fibronectin [23].

Other interactions of FNL1


Analytical, diagnostic and therapeutic context of FNL1


  1. Fibroblast stimulation in schistosomiasis. IV. Isolated egg granulomas elaborate a fibroblast chemoattractant in vitro. Wyler, D.J., Postlethwaite, A.E. J. Immunol. (1983) [Pubmed]
  2. Comparative adherence to human A549 cells, plant fibronectin-like protein, and polystyrene surfaces of four Pseudomonas fluorescens strains from different ecological origin. Cossard, E., Gallet, O., Di Martino, P. Can. J. Microbiol. (2005) [Pubmed]
  3. Secretion of a fibronectin-like substance from head and neck carcinomas. Sakumoto, M., Tsukuda, M., Mochimatsu, I., Yago, T., Kokatsu, T. ORL J. Otorhinolaryngol. Relat. Spec. (1994) [Pubmed]
  4. A novel tenascin type III repeat is part of a complex of tenascin mRNA alternative splices. Sriramarao, P., Bourdon, M.A. Nucleic Acids Res. (1993) [Pubmed]
  5. Affinity of fibronectin to collagens of different genetic types and to fibrinogen. Engvall, E., Ruoslahti, E., Miller, E.J. J. Exp. Med. (1978) [Pubmed]
  6. Autoimmune myocarditis induced in mice by cardiac C-protein. Cloning of complementary DNA encoding murine cardiac C-protein and partial characterization of the antigenic peptides. Kasahara, H., Itoh, M., Sugiyama, T., Kido, N., Hayashi, H., Saito, H., Tsukita, S., Kato, N. J. Clin. Invest. (1994) [Pubmed]
  7. Serum levels of fibronectin and a fibronectin-like DNA-binding protein in patients with various diseases. Todd, H.D., Coffee, M.S., Waalkes, T.P., Abeloff, M.D., Parsons, R.G. J. Natl. Cancer Inst. (1980) [Pubmed]
  8. Fishing out proteins that bind to titin. Sanger, J.W., Sanger, J.M. J. Cell Biol. (2001) [Pubmed]
  9. Hexabrachion proteins in embryonic chicken tissues and human tumors. Erickson, H.P., Taylor, H.C. J. Cell Biol. (1987) [Pubmed]
  10. Fibronectin-like protein in Porifera: its role in cell aggregation. Labat-Robert, J., Robert, L., Auger, C., Lethias, C., Garrone, R. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  11. Alanine scanning mutagenesis and functional analysis of the fibronectin-like collagen-binding domain from human 92-kDa type IV collagenase. Collier, I.E., Krasnov, P.A., Strongin, A.Y., Birkedal-Hansen, H., Goldberg, G.I. J. Biol. Chem. (1992) [Pubmed]
  12. Hemidesmosome assembly assessed by expression of a wild-type integrin beta 4 cDNA in junctional epidermolysis bullosa keratinocytes. Gagnoux-Palacios, L., Gache, Y., Ortonne, J.P., Meneguzzi, G. Lab. Invest. (1997) [Pubmed]
  13. Anti-adhesive glycosylation of fibronectin-like molecules in human placental matrix-type fibrinoid. Frank, H.G., Huppertz, B., Kertschanska, S., Blanchard, D., Roelcke, D., Kaufmann, P. Histochem. Cell Biol. (1995) [Pubmed]
  14. Extracellular matrix binding properties of recombinant fibronectin type II-like modules of human 72-kDa gelatinase/type IV collagenase. High affinity binding to native type I collagen but not native type IV collagen. Steffensen, B., Wallon, U.M., Overall, C.M. J. Biol. Chem. (1995) [Pubmed]
  15. alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo. Hertzler, P.L., McClay, D.R. Dev. Biol. (1999) [Pubmed]
  16. Fibronectin associated with infiltrating T lymphocytes. Evidence for in situ localization in biopsies and synthesis in vitro. Sundqvist, K.G., Wanger, L., Heimdahl, A., Lönnqvist, B., Hauzenberger, D. Eur. J. Immunol. (1991) [Pubmed]
  17. Fibronectin-like immunoreactivity in Helisoma buccal ganglia: evidence that an endogenous fibronectin-like molecule promotes neurite outgrowth. Mattson, M.P., Kater, S.B. J. Neurobiol. (1988) [Pubmed]
  18. A cDNA clone for cytotactin contains sequences similar to epidermal growth factor-like repeats and segments of fibronectin and fibrinogen. Jones, F.S., Burgoon, M.P., Hoffman, S., Crossin, K.L., Cunningham, B.A., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  19. The beta 4 subunit cytoplasmic domain mediates the interaction of alpha 6 beta 4 integrin with the cytoskeleton of hemidesmosomes. Spinardi, L., Ren, Y.L., Sanders, R., Giancotti, F.G. Mol. Biol. Cell (1993) [Pubmed]
  20. Fibronectin is apparently not involved in species-specific reaggregation of cells from the marine sponge geodia cydonium. Conrad, J., Diehl-Seifert, B., Zahn, R.K., Uhlenbruck, G., Zimmermann, E., Müller, W.E. J. Cell. Biochem. (1982) [Pubmed]
  21. Characterization and fine-structural localization of actin- and fibronectin-like proteins in planaria (Dugesia lugubris s.l.). Pascolini, R., Panara, F., Di Rosa, I., Fagotti, A., Lorvik, S. Cell Tissue Res. (1992) [Pubmed]
  22. Substrate recognition by gelatinase A: the C-terminal domain facilitates surface diffusion. Collier, I.E., Saffarian, S., Marmer, B.L., Elson, E.L., Goldberg, G. Biophys. J. (2001) [Pubmed]
  23. The biochemical identification of fibronectin in the sea urchin embryo. DeSimone, D.W., Spiegel, E., Spiegel, M. Biochem. Biophys. Res. Commun. (1985) [Pubmed]
  24. Undulin is a novel member of the fibronectin-tenascin family of extracellular matrix glycoproteins. Just, M., Herbst, H., Hummel, M., Dürkop, H., Tripier, D., Stein, H., Schuppan, D. J. Biol. Chem. (1991) [Pubmed]
  25. Identification of a fibronectin-like molecule on Eimeria tenella. Lopez-Bernad, F., Del Cacho, E., Gallego, M., Quilez, J., Sanchez-Acedo, C. Parasitology (1996) [Pubmed]
  26. Seminal fibronectin-like antigen and transferrin concentrations in infertile and fertile men. Anapliotou, M.L., Goulandris, N., Douvara, R. Andrologia (1995) [Pubmed]
  27. Different susceptibility of small and large human tenascin-C isoforms to degradation by matrix metalloproteinases. Siri, A., Knäuper, V., Veirana, N., Caocci, F., Murphy, G., Zardi, L. J. Biol. Chem. (1995) [Pubmed]
  28. Interaction between PEVK-titin and actin filaments: origin of a viscous force component in cardiac myofibrils. Kulke, M., Fujita-Becker, S., Rostkova, E., Neagoe, C., Labeit, D., Manstein, D.J., Gautel, M., Linke, W.A. Circ. Res. (2001) [Pubmed]
  29. Laminin- and fibronectin-like molecules produced by periodontal ligament fibroblasts under serum-free culture are potent chemoattractants for gingival epithelial cells. Ohshima, M., Tokunaga, K., Sato, S., Maeno, M., Otsuka, K. J. Periodont. Res. (2003) [Pubmed]
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