Characterization of the fliL gene in the flagellar regulon of Escherichia coli and Salmonella typhimurium.
filL is a small gene of unknown function that lies within the beginning of a large flagellar operon of Salmonella typhimurium and Escherichia coli. A spontaneous fliL mutant of S. typhimurium, containing a frameshift mutation about 40% from the 3' end of the gene, was moderately motile but swarmed poorly, suggesting that FliL might be a component of the flagellar motor or switch. However, in-frame deletions of the E. coli gene, including an essentially total deletion, had little or no effect on motility or chemotaxis. Thus, FliL does not appear to have a major role in flagellar structure or function and is therefore unlikely to be a component of the motor or switch; the effect on motility caused by truncation of the gene is probably an indirect one.[1]References
- Characterization of the fliL gene in the flagellar regulon of Escherichia coli and Salmonella typhimurium. Raha, M., Sockett, H., Macnab, R.M. J. Bacteriol. (1994) [Pubmed]
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