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Gene Review

fliL  -  flagellar biosynthesis protein

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK1942, JW1928, cheC1, flaAI, flaQI
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Disease relevance of fliL


High impact information on fliL

  • However, B. subtilis contains several chemotaxis genes not found in the E. coli genome, such as cheC and cheD, indicating that the B. subtilis chemotactic system is more complex [6].
  • The deletion strain lacks motility and belongs to the fla(-) mutant class, indicating that it is deficient in flagellar biogenesis [7].
  • The fla gene cluster is involved in the biogenesis of flagella in Halobacterium salinarum [7].
  • Region I was shown to include at least 12 fla cistrons [8].
  • The timing of fla gene expression in the cell cycle is determined by specialized forms of RNA polymerase and the appearance and/or activation of regulatory proteins [9].

Chemical compound and disease context of fliL

  • Our results help to define the features of the Ntr/Nif-type consensus sequence required for promoter utilization by purified E. coli E sigma 54 and support the idea that C. crescentus may contain a specialized polymerase with similar promoter specificity required for expression of a set of fla genes [5].

Biological context of fliL


Anatomical context of fliL

  • No analogs to the bacterial chemotactic and motility (che, mot, fla) genes, genes for a two-component signal transduction system, genes associated with gliding, or genomic homologs for the eukaryotic cytoskeleton and motor proteins were found in the Mollicutes [12].

Associations of fliL with chemical compounds

  • The tumbling of cheB or cheE mutants was depressed after prolonged methionine starvation in the presence of a constant level of an attractant. cheC tumbling mutants appeared unique in that they did not cease tumbling even when cells were deprived of methionine [13].
  • It was found that transcription of genes responsible for the formation and/or function of flagella (hag, fla, mot, che) decreased significantly at 40 degrees C. However, in the ftsI730 mutant at the nonpermissive temperature, or in penicillin G treated wild-type cells, cell division was blocked but formation of flagella continued [14].

Analytical, diagnostic and therapeutic context of fliL


  1. Early Caulobacter crescentus genes fliL and fliM are required for flagellar gene expression and normal cell division. Yu, J., Shapiro, L. J. Bacteriol. (1992) [Pubmed]
  2. Sequence of the flaA (cheC) locus of Escherichia coli and discovery of a new gene. Kuo, S.C., Koshland, D.E. J. Bacteriol. (1986) [Pubmed]
  3. Two classes of region III flagellar genes in Escherichia coli. Kondoh, H., Ozeki, H. J. Bacteriol. (1981) [Pubmed]
  4. Genetic analysis of three additional fla genes in Salmonella typhimurium. Yamaguchi, S., Fujita, H., Taira, T., Kutsukake, K., Homma, M., Iino, T. J. Gen. Microbiol. (1984) [Pubmed]
  5. Escherichia coli sigma 54 RNA polymerase recognizes Caulobacter crescentus flbG and flaN flagellar gene promoters in vitro. Ninfa, A.J., Mullin, D.A., Ramakrishnan, G., Newton, A. J. Bacteriol. (1989) [Pubmed]
  6. Bacillus subtilis CheD is a chemoreceptor modification enzyme required for chemotaxis. Kristich, C.J., Ordal, G.W. J. Biol. Chem. (2002) [Pubmed]
  7. The fla gene cluster is involved in the biogenesis of flagella in Halobacterium salinarum. Patenge, N., Berendes, A., Engelhardt, H., Schuster, S.C., Oesterhelt, D. Mol. Microbiol. (2001) [Pubmed]
  8. Definition of additional flagellar genes in Escherichia coli K12. Komeda, Y., Kutsukake, K., Iino, T. Genetics (1980) [Pubmed]
  9. Global regulation of a sigma 54-dependent flagellar gene family in Caulobacter crescentus by the transcriptional activator FlbD. Wu, J., Benson, A.K., Newton, A. J. Bacteriol. (1995) [Pubmed]
  10. DNA sequence analysis, gene product identification, and localization of flagellar motor components of Escherichia coli. Malakooti, J., Komeda, Y., Matsumura, P. J. Bacteriol. (1989) [Pubmed]
  11. Characterization of the fliL gene in the flagellar regulon of Escherichia coli and Salmonella typhimurium. Raha, M., Sockett, H., Macnab, R.M. J. Bacteriol. (1994) [Pubmed]
  12. Shaping and moving a spiroplasma. Trachtenberg, S. J. Mol. Microbiol. Biotechnol. (2004) [Pubmed]
  13. Tumbling chemotaxis mutants of Escherichia coli: possible gene-dependent effect of methionine starvation. Kondoh, H. J. Bacteriol. (1980) [Pubmed]
  14. A cell division regulatory mechanism controls the flagellar regulon in Escherichia coli. Nishimura, A., Hirota, Y. Mol. Gen. Genet. (1989) [Pubmed]
  15. An approach to the functional analysis of lecithin-cholesterol acyltransferase. Activation by recombinant normal and mutagenized apolipoprotein AI. Bruhn, H., Stoffel, W. Biol. Chem. Hoppe-Seyler (1991) [Pubmed]
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