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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit.

We have isolated a mutant, mts2, in the fission yeast Schizosaccharomyces pombe which is defective in chromosome segregation. The predicted amino-acid sequence of the cloned mts2+ gene product is 75% identical to the S4 subunit of the human 26S ATP/ubiquitin-dependent protease. The human S4 subunit complementary DNA expressed from an S. pombe expression plasmid can rescue an S. pombe mts2 gene disruption. Both observations demonstrate that the mts2+ gene is the S. pombe homologue of the human S4 subunit. In addition, we provide genetic evidence for a physical interaction between the S4 and the related S7 subunit in the 26S multiprotein protease. We show that polyubiquitin-conjugated proteins accumulate in the mts2 mutant at the restrictive temperature, demonstrating that the mutant has an in vivo defect in the ubiquitin-dependent proteolysis pathway. Finally, the phenotype for the mts2 mutant indicates that protein degradation by the 26S protease is essential not for entry into but for the completion of mitosis.[1]


  1. Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit. Gordon, C., McGurk, G., Dillon, P., Rosen, C., Hastie, N.D. Nature (1993) [Pubmed]
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