The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PSMC2  -  proteasome (prosome, macropain) 26S...

Homo sapiens

Synonyms: 26S protease regulatory subunit 7, 26S proteasome AAA-ATPase subunit RPT1, MSS1, Nbla10058, Proteasome 26S subunit ATPase 2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PSMC2


High impact information on PSMC2

  • In addition, we provide genetic evidence for a physical interaction between the S4 and the related S7 subunit in the 26S multiprotein protease [4].
  • Tests for association in Duke and AGRE families were also performed on four additional SNPs in the genes PSMC2 and ORC5L, which flank RELN [5].
  • Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase) [6].
  • We have used fluorescence in situ hybridization (FISH) to localize S7 to chromosome 2p25 [7].
  • The S7 gene contains seven exons and six introns spanning about 6 kb [7].

Biological context of PSMC2


Associations of PSMC2 with chemical compounds

  • In striking contrast, truncation of 85 NH2-terminal amino acids from S4 abrogated binding, clearly implicating the NH2 terminus of S4 in its specific interaction with S7 [11].

Physical interactions of PSMC2

  • Progressive COOH-terminal deletions that removed as much as 300 amino acids from S4 had no effect on the binding of S4 to S7 [11].

Analytical, diagnostic and therapeutic context of PSMC2

  • By means of chemical cross-linking, immunoprecipitation, and blotting, we have determined that the ATPases are organized in the order S6-S6'-S10b-S8-S4-S7 [12].
  • The Mixed Stain Study 1 (MSS1, Apr.-Nov. 1997) and Mixed Stain Study 2 (MSS2, Jan.-May 1999) evaluated multiplexed short-tandem repeat (STR) DNA typing systems with samples containing DNA from more than one source [13].


  1. Alterations in a yeast protein resembling HIV Tat-binding protein relieve requirement for an acidic activation domain in GAL4. Swaffield, J.C., Bromberg, J.F., Johnston, S.A. Nature (1992) [Pubmed]
  2. A homologue of the human MSS1 gene, a positive modulator of HIV-1 gene expression, is massively expressed in Xenopus oocytes. Nacken, W., Kingsman, A.J., Kingsman, S.M., Sablitzky, F., Sorg, C. Biochim. Biophys. Acta (1995) [Pubmed]
  3. Manipulation of the ubiquitin-proteasome pathway in cachexia: pentoxifylline suppresses the activation of 20S and 26S proteasomes in muscles from tumor-bearing rats. Combaret, L., Rallière, C., Taillandier, D., Tanaka, K., Attaix, D. Mol. Biol. Rep. (1999) [Pubmed]
  4. Defective mitosis due to a mutation in the gene for a fission yeast 26S protease subunit. Gordon, C., McGurk, G., Dillon, P., Rosen, C., Hastie, N.D. Nature (1993) [Pubmed]
  5. Analysis of the RELN gene as a genetic risk factor for autism. Skaar, D.A., Shao, Y., Haines, J.L., Stenger, J.E., Jaworski, J., Martin, E.R., DeLong, G.R., Moore, J.H., McCauley, J.L., Sutcliffe, J.S., Ashley-Koch, A.E., Cuccaro, M.L., Folstein, S.E., Gilbert, J.R., Pericak-Vance, M.A. Mol. Psychiatry (2005) [Pubmed]
  6. Structural locations and functional roles of new subsites S5, S6, and S7 in memapsin 2 (beta-secretase). Turner, R.T., Hong, L., Koelsch, G., Ghosh, A.K., Tang, J. Biochemistry (2005) [Pubmed]
  7. The human ribosomal protein S7-encoding gene: isolation, structure and localization in 2p25. Annilo, T., Laan, M., Stahl, J., Metspalu, A. Gene (1995) [Pubmed]
  8. Gene expression profile changes in NB4 cells induced by realgar. Wang, H., Liu, S., Lu, X., Zhao, X., Chen, S., Li, X. Chin. Med. J. (2003) [Pubmed]
  9. A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily. Choi, H.S., Seol, W., Moore, D.D. J. Steroid Biochem. Mol. Biol. (1996) [Pubmed]
  10. Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease. Dubiel, W., Ferrell, K., Rechsteiner, M. FEBS Lett. (1993) [Pubmed]
  11. Specific interactions between ATPase subunits of the 26 S protease. Richmond, C., Gorbea, C., Rechsteiner, M. J. Biol. Chem. (1997) [Pubmed]
  12. Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linking. Hartmann-Petersen, R., Tanaka, K., Hendil, K.B. Arch. Biochem. Biophys. (2001) [Pubmed]
  13. NIST mixed stain studies #1 and #2: interlaboratory comparison of DNA quantification practice and short tandem repeat multiplex performance with multiple-source samples. Duewer, D.L., Kline, M.C., Redman, J.W., Newall, P.J., Reeder, D.J. J. Forensic Sci. (2001) [Pubmed]
WikiGenes - Universities