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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

A receptor for interleukin 10 is related to interferon receptors.

We isolated cDNAs encoding a mouse interleukin 10 receptor (mIL-10R) from mouse mast cell and macrophage cell lines. The two cDNAs are substantially identical and express an approximately 110-kDa polypeptide in COS7 cells, which binds mIL-10 specifically. A mouse pro-B-cell line (Ba/F3) expressing transfected recombinant mIL-10R binds IL-10 with high affinity (approximately 70 pM) and proliferates in response to mIL-10. mIL-10R is structurally related to interferon receptors (IFNRs). Since IL-10 inhibits macrophage activation by IFN-gamma, a possible implication of this relationship interaction of IL-10R and IFN-gamma R or their signaling pathways.[1]

References

  1. A receptor for interleukin 10 is related to interferon receptors. Ho, A.S., Liu, Y., Khan, T.A., Hsu, D.H., Bazan, J.F., Moore, K.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
 
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