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Gene Review

Ifngr1  -  interferon gamma receptor 1

Mus musculus

Synonyms: CD119, IFN-gamma R, IFN-gamma receptor 1, IFN-gamma-R1, IFN-gammaR, ...
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Disease relevance of Ifngr1


Psychiatry related information on Ifngr1

  • The relatively increased resistance of IFN-gamma R(-/-) mice was not related to favorable effects on defense mechanisms known to contribute to antibacterial immunity-that is, the neutrophilic influx was reduced and the cytokine and nitric oxide levels were similar or lower in IFN-gamma R(-/-) mice [4].

High impact information on Ifngr1


Biological context of Ifngr1


Anatomical context of Ifngr1


Associations of Ifngr1 with chemical compounds


Physical interactions of Ifngr1


Co-localisations of Ifngr1

  • As viewed by confocal microscopy, the immunopositivity for the IFN-gamma R was co-localized with that of the presynaptic marker synaptophysin and with neuronal nitric oxide synthase in the lateral spinal nucleus, whereas only a minor overlap with these molecules was observed in laminae I and II of the dorsal horn [22].

Regulatory relationships of Ifngr1


Other interactions of Ifngr1


Analytical, diagnostic and therapeutic context of Ifngr1

  • Sequence analysis of the cDNA encoding the Mu-IFN-gamma R and comparison with the corresponding human IFN-gamma R sequence shows about 68% conservation of the extracellular domains and 51% conservation of the cytoplasmic domains at the nucleotide level [11].
  • Despite potentially strong modulating effects of IFN-gamma on epithelial cell IgA transcytosis and electrolyte barrier functions, CT-immunized IFN-gamma R -/- mice demonstrated unaltered protection against CT in ligated intestinal loops together with normal anti-CT IgA and total IgA levels in gut lavage [16].
  • We show that i.m. injections of this vector as naked DNA in mice results in secretion of IFN gamma R/IgG1, with serum levels exceeding 100 ng/ml for months after treatment [28].
  • Prevention of autoimmune diabetes by intramuscular gene therapy with a nonviral vector encoding an interferon-gamma receptor/IgG1 fusion protein [28].
  • Functional characterization of a hybrid human-mouse interferon gamma receptor: evidence for species-specific interaction of the extracellular receptor domain with a putative signal transducer [29].


  1. Mice that lack the interferon-gamma receptor have profoundly altered responses to infection with Bacillus Calmette-Guérin and subsequent challenge with lipopolysaccharide. Kamijo, R., Le, J., Shapiro, D., Havell, E.A., Huang, S., Aguet, M., Bosland, M., Vilcek, J. J. Exp. Med. (1993) [Pubmed]
  2. Interferon gamma receptor deficient mice are resistant to endotoxic shock. Car, B.D., Eng, V.M., Schnyder, B., Ozmen, L., Huang, S., Gallay, P., Heumann, D., Aguet, M., Ryffel, B. J. Exp. Med. (1994) [Pubmed]
  3. IL-4-deficient Balb/c mice resist infection with Leishmania major. Kopf, M., Brombacher, F., Köhler, G., Kienzle, G., Widmann, K.H., Lefrang, K., Humborg, C., Ledermann, B., Solbach, W. J. Exp. Med. (1996) [Pubmed]
  4. The role of interferon-gamma in murine pneumococcal pneumonia. Rijneveld, A.W., Lauw, F.N., Schultz, M.J., Florquin, S., Te Velde, A.A., Speelman, P., Van Deventer, S.J., Van Der Poll, T. J. Infect. Dis. (2002) [Pubmed]
  5. A novel member of the interferon receptor family complements functionality of the murine interferon gamma receptor in human cells. Hemmi, S., Böhni, R., Stark, G., Di Marco, F., Aguet, M. Cell (1994) [Pubmed]
  6. Gene targeting in normal somatic cells: inactivation of the interferon-gamma receptor in myoblasts. Arbonés, M.L., Austin, H.A., Capon, D.J., Greenburg, G. Nat. Genet. (1994) [Pubmed]
  7. Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in TH1 cells. Pernis, A., Gupta, S., Gollob, K.J., Garfein, E., Coffman, R.L., Schindler, C., Rothman, P. Science (1995) [Pubmed]
  8. Immune response in mice that lack the interferon-gamma receptor. Huang, S., Hendriks, W., Althage, A., Hemmi, S., Bluethmann, H., Kamijo, R., Vilcek, J., Zinkernagel, R.M., Aguet, M. Science (1993) [Pubmed]
  9. Inhibition of methylcholanthrene-induced carcinogenesis by an interferon gamma receptor-dependent foreign body reaction. Qin, Z., Kim, H.J., Hemme, J., Blankenstein, T. J. Exp. Med. (2002) [Pubmed]
  10. Expression and reconstitution of a biologically active mouse interferon gamma receptor in hamster cells. Chromosomal location of an accessory factor. Hibino, Y., Mariano, T.M., Kumar, C.S., Kozak, C.A., Pestka, S. J. Biol. Chem. (1991) [Pubmed]
  11. Molecular characterization of the murine interferon gamma receptor cDNA. Kumar, C.S., Muthukumaran, G., Frost, L.J., Noe, M., Ahn, Y.H., Mariano, T.M., Pestka, S. J. Biol. Chem. (1989) [Pubmed]
  12. Gestation-related expression of the interferon-gamma receptor gene in mouse uterine and embryonic hematopoietic cells. Chen, H.L., Kamath, R., Pace, J.L., Russell, S.W., Hunt, J.S. J. Leukoc. Biol. (1994) [Pubmed]
  13. Interferon-gamma receptor-mediated but not tumor necrosis factor receptor type 1- or type 2-mediated signaling is crucial for the activation of cerebral blood vessel endothelial cells and microglia in murine Toxoplasma encephalitis. Deckert-Schlüter, M., Bluethmann, H., Kaefer, N., Rang, A., Schlüter, D. Am. J. Pathol. (1999) [Pubmed]
  14. Interferon-gamma receptor-deficiency renders mice highly susceptible to toxoplasmosis by decreased macrophage activation. Deckert-Schlüter, M., Rang, A., Weiner, D., Huang, S., Wiestler, O.D., Hof, H., Schlüter, D. Lab. Invest. (1996) [Pubmed]
  15. Impaired immunity and altered pulmonary responses in mice with a disrupted interferon-gamma receptor gene exposed to the irradiated Schistosoma mansoni vaccine. Wilson, R.A., Coulson, P.S., Betts, C., Dowling, M.A., Smythies, L.E. Immunology (1996) [Pubmed]
  16. Interferon-gamma receptor-deficient mice exhibit impaired gut mucosal immune responses but intact oral tolerance. Kjerrulf, M., Grdic, D., Ekman, L., Schön, K., Vajdy, M., Lycke, N.Y. Immunology (1997) [Pubmed]
  17. Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation. Qing, Y., Costa-Pereira, A.P., Watling, D., Stark, G.R. J. Biol. Chem. (2005) [Pubmed]
  18. IFN-gamma receptor-deficient mice are hypersensitive to the anti-CD3-induced cytokine release syndrome and thymocyte apoptosis. Protective role of endogenous nitric oxide. Matthys, P., Froyen, G., Verdot, L., Huang, S., Sobis, H., Van Damme, J., Vray, B., Aguet, M., Billiau, A. J. Immunol. (1995) [Pubmed]
  19. Interferon gamma signals via a high-affinity multisubunit receptor complex that contains two types of polypeptide chain. Marsters, S.A., Pennica, D., Bach, E., Schreiber, R.D., Ashkenazi, A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  20. Role of interferon-gamma in contact hypersensitivity assessed in interferon-gamma receptor-deficient mice. Saulnier, M., Huang, S., Aguet, M., Ryffel, B. Toxicology (1995) [Pubmed]
  21. Generation of nitric oxide and induction of major histocompatibility complex class II antigen in macrophages from mice lacking the interferon gamma receptor. Kamijo, R., Shapiro, D., Le, J., Huang, S., Aguet, M., Vilcek, J. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  22. Interferon-gamma receptors are expressed at synapses in the rat superficial dorsal horn and lateral spinal nucleus. Vikman, K., Robertson, B., Grant, G., Liljeborg, A., Kristensson, K. J. Neurocytol. (1998) [Pubmed]
  23. Stable expression of a secreted form of the mouse IFN-gamma receptor by rat cells. Fernando, L.P., LeClaire, R.D., Obici, S., Zavodny, P.J., Russell, S.W., Pace, J.L. J. Immunol. (1991) [Pubmed]
  24. Toll-like receptor 2 stimulation decreases IFN-gamma receptor expression in mouse RAW264.7 macrophages. Curry, H., Alvarez, G.R., Zwilling, B.S., Lafuse, W.P. J. Interferon Cytokine Res. (2004) [Pubmed]
  25. Neural route of cerebral Listeria monocytogenes murine infection: role of immune response mechanisms in controlling bacterial neuroinvasion. Jin, Y., Dons, L., Kristensson, K., Rottenberg, M.E. Infect. Immun. (2001) [Pubmed]
  26. Effect of lack of Interleukin-4, Interleukin-12, Interleukin-18, or the Interferon-gamma receptor on virus replication, cytokine response, and lung pathology during respiratory syncytial virus infection in mice. Boelen, A., Kwakkel, J., Barends, M., de Rond, L., Dormans, J., Kimman, T. J. Med. Virol. (2002) [Pubmed]
  27. A new mouse mutation causing male sterility and histoincompatibility. Ward-Bailey, P.F., Johnson, K.R., Handel, M.A., Harris, B.S., Davisson, M.T. Mamm. Genome (1996) [Pubmed]
  28. Prevention of autoimmune diabetes by intramuscular gene therapy with a nonviral vector encoding an interferon-gamma receptor/IgG1 fusion protein. Prud'homme, G.J., Chang, Y. Gene Ther. (1999) [Pubmed]
  29. Functional characterization of a hybrid human-mouse interferon gamma receptor: evidence for species-specific interaction of the extracellular receptor domain with a putative signal transducer. Hemmi, S., Merlin, G., Aguet, M. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
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