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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Ablation of luteal phase symptoms of Menière's disease with leuprolide.

Symptoms of Menière's disease in women may be exacerbated during the luteal phase of the menstrual cycle. This suggests a role for progesterone production and subsequent fluid redistribution as a predisposing factor for Menière's symptoms. We report the use of leuprolide acetate, a gonadotropin-releasing hormone agonist, in a woman with cyclic Menière's symptoms. This drug, which abolishes gonadotropin-dependent ovarian sex steroid production, alleviated the patient's symptoms during therapy. This observation offers further support to the hypothesis of sex hormone-related exacerbations of Menière's symptoms and provides a possible future treatment option for this debilitating disease.[1]


  1. Ablation of luteal phase symptoms of Menière's disease with leuprolide. Price, T.M., Allen, T.C., Bowyer, D.L., Watson, T.A. Arch. Otolaryngol. Head Neck Surg. (1994) [Pubmed]
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