- Patients with Graves' disease who developed insulin autoimmune syndrome (Hirata disease) possess HLA-Bw62/Cw4/DR4 carrying DRB1*0406. Uchigata, Y., Kuwata, S., Tsushima, T., Tokunaga, K., Miyamoto, M., Tsuchikawa, K., Hirata, Y., Juji, T., Omori, Y. J. Clin. Endocrinol. Metab. (1993)