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MeSH Review

DNA Fingerprinting

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Disease relevance of DNA Fingerprinting


High impact information on DNA Fingerprinting


Chemical compound and disease context of DNA Fingerprinting


Biological context of DNA Fingerprinting


Anatomical context of DNA Fingerprinting


Associations of DNA Fingerprinting with chemical compounds


Gene context of DNA Fingerprinting

  • Among the 75 mismatched pairs, DNA typing of 63 pairs showed that 51 were mismatched at 1 HLA locus (18 HLA-A, 11 HLA-B, 22 HLA-DRB1) and 12 were mismatched at 2 or more loci [31].
  • Cytogenetics, DNA profiling, expression of basal, luminal, and neuroendocrine differentiation markers, and mutation analyses of the TP53 and androgen receptor (AR) genes were performed [32].
  • Rapid DNA typing for HLA-C using sequence-specific primers (PCR-SSP): identification of serological and non-serologically defined HLA-C alleles including several new alleles [33].
  • In conclusion, LR-HR-PCR-SSP typing is a fast and reliable typing technique for routine DNA typing purposes which gives complete DRB1 subtyping within 4.5 h [34].
  • Thus, PCR-RFLP seems to be one of the best DNA typing methods: it represents direct, accurate, fast, and nonradioactive typing for both HLA-DPA1 and HLA-DPB1 alleles [35].

Analytical, diagnostic and therapeutic context of DNA Fingerprinting

  • Sperm DNA typing using allele-specific PCR primers to selectively amplify recombinant TAP2 molecules revealed a highly localized meiotic crossover hotspot approximately 1.2 kb long, unusually abundant in sequence polymorphisms and flanked by DNA much less active in recombination [36].
  • These small cells are presumably of donor origin based on DNA fingerprinting analysis and based on fluorescence in situ hybridization for the Y chromosome in a sex-mismatched case [37].
  • Multivariate analysis revealed the following unfavorable factors: transplantation more than 3 years after diagnosis (relative risk [RR], 1.86; P =.02), patients older than 20 years (RR, 2.27; P =.03), preconditioning regimen without antithymocyte globulin (RR 2.28; P =.04), and HLA-A or -B locus mismatching as determined by DNA typing [31].
  • Forensic DNA typing by capillary electrophoresis using the ABI Prism 310 and 3100 genetic analyzers for STR analysis [38].
  • By a combination of DNA typing and isoelectric focusing of the C7 appearing after transfusion, it was demonstrated that the patient was heterozygous for combined subtotal C6/C7 deficiency (inherited from his father) and a different, so far uncharacterized, subtotal C7 deficiency (inherited from his mother) [39].


  1. The genomic damage estimated by arbitrarily primed PCR DNA fingerprinting is useful for the prognosis of gastric cancer. Suzuki, K., Ohnami, S., Tanabe, C., Sasaki, H., Yasuda, J., Katai, H., Yoshimura, K., Terada, M., Perucho, M., Yoshida, T. Gastroenterology (2003) [Pubmed]
  2. Clinical significance of HLA-DRB1*0410 in Japanese patients with idiopathic thrombocytopenic purpura. Nomura, S., Matsuzaki, T., Ozaki, Y., Yamaoka, M., Yoshimura, C., Katsura, K., Xie, G.L., Kagawa, H., Ishida, T., Fukuhara, S. Blood (1998) [Pubmed]
  3. Patients with Graves' disease who developed insulin autoimmune syndrome (Hirata disease) possess HLA-Bw62/Cw4/DR4 carrying DRB1*0406. Uchigata, Y., Kuwata, S., Tsushima, T., Tokunaga, K., Miyamoto, M., Tsuchikawa, K., Hirata, Y., Juji, T., Omori, Y. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  4. Widespread detection of PER-1-type extended-spectrum beta-lactamases among nosocomial Acinetobacter and Pseudomonas aeruginosa isolates in Turkey: a nationwide multicenter study. Vahaboglu, H., Oztürk, R., Aygün, G., Coşkunkan, F., Yaman, A., Kaygusuz, A., Leblebicioglu, H., Balik, I., Aydin, K., Otkun, M. Antimicrob. Agents Chemother. (1997) [Pubmed]
  5. Parallel genome analysis by one- and two-dimensional DNA fingerprinting in human gliomas. Nürnberg, P., Marczinek, K., Thiel, G., Hampe, J. Electrophoresis (1995) [Pubmed]
  6. Widespread distribution of urinary tract infections caused by a multidrug-resistant Escherichia coli clonal group. Manges, A.R., Johnson, J.R., Foxman, B., O'Bryan, T.T., Fullerton, K.E., Riley, L.W. N. Engl. J. Med. (2001) [Pubmed]
  7. Effect of matching of class I HLA alleles on clinical outcome after transplantation of hematopoietic stem cells from an unrelated donor. Japan Marrow Donor Program. Sasazuki, T., Juji, T., Morishima, Y., Kinukawa, N., Kashiwabara, H., Inoko, H., Yoshida, T., Kimura, A., Akaza, T., Kamikawaji, N., Kodera, Y., Takaku, F. N. Engl. J. Med. (1998) [Pubmed]
  8. DNA fingerprinting: the NRC report. Lander, E.S. Science (1993) [Pubmed]
  9. Susceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen. Lukacher, A.E., Ma, Y., Carroll, J.P., Abromson-Leeman, S.R., Laning, J.C., Dorf, M.E., Benjamin, T.L. J. Exp. Med. (1995) [Pubmed]
  10. The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing. Newman, P.J., Derbes, R.S., Aster, R.H. J. Clin. Invest. (1989) [Pubmed]
  11. Random amplified polymorphic DNA assay is less discriminant than pulsed-field gel electrophoresis for typing strains of methicillin-resistant Staphylococcus aureus. Saulnier, P., Bourneix, C., Prévost, G., Andremont, A. J. Clin. Microbiol. (1993) [Pubmed]
  12. Occurence of resistance mutation and clonal expansion in Helicobacter pylori multiple-strain infection: a potential risk in clarithromycin-based therapy. Enroth, H., Björkholm, B., Engstrand, L. Clin. Infect. Dis. (1999) [Pubmed]
  13. Possible association of sudden infant death with partial complement C4 deficiency revealed by post-mortem DNA typing of HLA class II and III genes. Schneider, P.M., Wendler, C., Riepert, T., Braun, L., Schacker, U., Horn, M., Althoff, H., Mattern, R., Rittner, C. Eur. J. Pediatr. (1989) [Pubmed]
  14. Tuberculosis in Thai prisons: magnitude, transmission and drug susceptibility. Sretrirutchai, S., Silapapojakul, K., Palittapongarnpim, P., Phongdara, A., Vuddhakul, V. The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease. (2002) [Pubmed]
  15. Epidemiological analysis of methicillin-resistant Staphylococcus aureus in a Zagreb Trauma Hospital using a randomly amplified polymorphic DNA-typing method. Tambic, A., Power, E.G., Tambic, T., Snur, I., French, G.L. Eur. J. Clin. Microbiol. Infect. Dis. (1999) [Pubmed]
  16. DNA typing for HLA-A and HLA-B identifies disparities between patients and unrelated donors matched by HLA-A and HLA-B serology and HLA-DRB1. Prasad, V.K., Kernan, N.A., Heller, G., O'Reilly, R.J., Yang, S.Y. Blood (1999) [Pubmed]
  17. Allele-specific MVR-PCR analysis at minisatellite D1S8. Monckton, D.G., Tamaki, K., MacLeod, A., Neil, D.L., Jeffreys, A.J. Hum. Mol. Genet. (1993) [Pubmed]
  18. Chimerism of metanephric adenoma but not of carcinoma in kidney transplants. Mengel, M., Jonigk, D., Wilkens, L., Radermacher, J., von Wasielewski, R., Lehmann, U., Haller, H., Mihatsch, M., Kreipe, H. Am. J. Pathol. (2004) [Pubmed]
  19. Analysis of multigene families by DNA fingerprinting of conserved domains: directed cloning of tissue-specific protein tyrosine phosphatases. Boehm, T. Oncogene (1993) [Pubmed]
  20. DNA profiling. Monckton, D.G., Jeffreys, A.J. Curr. Opin. Biotechnol. (1993) [Pubmed]
  21. Electrophoretic human leukocyte antigen HLA-DQA1 DNA typing after polymerase chain reaction amplification. Barros, F., Carracedo, A., Lareu, M.V., Rodriguez-Calvo, M.S. Electrophoresis (1991) [Pubmed]
  22. Unrelated donor cord blood transplantation in adults with chronic myelogenous leukemia: results in nine patients from a single institution. Sanz, G.F., Saavedra, S., Jiménez, C., Senent, L., Cervera, J., Planelles, D., Bolufer, P., Larrea, L., Martín, G., Martínez, J., Jarque, I., Moscardó, F., Plumé, G., Andreu, R., de la Rubia, J., Barragán, E., Solves, P., Soler, M.A., Sanz, M.A. Bone Marrow Transplant. (2001) [Pubmed]
  23. Vertical transmission of Citrobacter diversus documented by DNA fingerprinting. Harvey, B.S., Koeuth, T., Versalovic, J., Woods, C.R., Lupski, J.R. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America. (1995) [Pubmed]
  24. Changes in DNA induced by toxic agents. Sawaguchi, T., Wang, X., Sawaguchi, A. Forensic Sci. Int. (1996) [Pubmed]
  25. Mycobacterium tuberculosis transmission among high school students in Greece. Hadjichristodoulou, C., Vasilogiannakopoulos, A., Spala, G., Mavrou, I., Kolonia, V., Marinis, E., Syriopoulou, V., Theodoridou, M. Pediatrics international : official journal of the Japan Pediatric Society. (2005) [Pubmed]
  26. The poly (purine) poly (pyrimidine) sequence in the 5' end of the thyroglobulin gene used as a probe, identifies a DNA fingerprint in man. Gérard, C., Christophe, D., Compère, T., Vassart, G. Nucleic Acids Res. (1990) [Pubmed]
  27. Spoligologos: a bioinformatic approach to displaying and analyzing Mycobacterium tuberculosis data. Driscoll, J.R., Bifani, P.J., Mathema, B., McGarry, M.A., Zickas, G.M., Kreiswirth, B.N., Taber, H.W. Emerging Infect. Dis. (2002) [Pubmed]
  28. Temperature and pH studies of short tandem repeat systems using capillary electrophoresis at elevated pH. Nock, T., Dove, J., McCord, B., Mao, D. Electrophoresis (2001) [Pubmed]
  29. Emergence of a pneumococcal clone with cephalosporin resistance and penicillin susceptibility. Smith, A.M., Botha, R.F., Koornhof, H.J., Klugman, K.P. Antimicrob. Agents Chemother. (2001) [Pubmed]
  30. Outbreak of cefozopran (penicillin, oral cephems, and aztreonam)-resistant Neisseria gonorrhoeae in Japan. Muratani, T., Akasaka, S., Kobayashi, T., Yamada, Y., Inatomi, H., Takahashi, K., Matsumoto, T. Antimicrob. Agents Chemother. (2001) [Pubmed]
  31. Outcome of 154 patients with severe aplastic anemia who received transplants from unrelated donors: the Japan Marrow Donor Program. Kojima, S., Matsuyama, T., Kato, S., Kigasawa, H., Kobayashi, R., Kikuta, A., Sakamaki, H., Ikuta, K., Tsuchida, M., Hoshi, Y., Morishima, Y., Kodera, Y. Blood (2002) [Pubmed]
  32. Molecular characterization of human prostate carcinoma cell lines. van Bokhoven, A., Varella-Garcia, M., Korch, C., Johannes, W.U., Smith, E.E., Miller, H.L., Nordeen, S.K., Miller, G.J., Lucia, M.S. Prostate (2003) [Pubmed]
  33. Rapid DNA typing for HLA-C using sequence-specific primers (PCR-SSP): identification of serological and non-serologically defined HLA-C alleles including several new alleles. Bunce, M., Welsh, K.I. Tissue Antigens (1994) [Pubmed]
  34. High resolution HLA-DRB1 SSP typing for cadaveric donor transplantation. Savelkoul, P.H., de Bruyn-Geraets, D.P., van den Berg-Loonen, E.M. Tissue Antigens (1995) [Pubmed]
  35. Gene polymorphism of HLA-DPB1 and DPA1 loci in caucasoid population: frequencies and DPB1-DPA1 associations. al-Daccak, R., Wang, F.Q., Theophille, D., Lethielleux, P., Colombani, J., Loiseau, P. Hum. Immunol. (1991) [Pubmed]
  36. High resolution analysis of haplotype diversity and meiotic crossover in the human TAP2 recombination hotspot. Jeffreys, A.J., Ritchie, A., Neumann, R. Hum. Mol. Genet. (2000) [Pubmed]
  37. Augmented proliferation of human alveolar macrophages after allogeneic bone marrow transplantation. Nakata, K., Gotoh, H., Watanabe, J., Uetake, T., Komuro, I., Yuasa, K., Watanabe, S., Ieki, R., Sakamaki, H., Akiyama, H., Kudoh, S., Naitoh, M., Satoh, H., Shimada, K. Blood (1999) [Pubmed]
  38. Forensic DNA typing by capillary electrophoresis using the ABI Prism 310 and 3100 genetic analyzers for STR analysis. Butler, J.M., Buel, E., Crivellente, F., McCord, B.R. Electrophoresis (2004) [Pubmed]
  39. How partial C7 deficiency with chronic and recurrent bacterial infections can mimic total C7 deficiency: temporary restoration of host C7 levels following plasma transfusion. Würzner, R., Platonov, A.E., Beloborodov, V.B., Pereverzev, A.I., Vershinina, I.V., Fernie, B.A., Hobart, M.J., Lachmann, P.J., Orren, A. Immunology (1996) [Pubmed]
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