- The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis. Tsutsumi, K., Inoue, Y., Shima, A., Iwasaki, K., Kawamura, M., Murase, T. J. Clin. Invest. (1993)