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Gene Review

Lpl  -  lipoprotein lipase

Rattus norvegicus

Synonyms: LPL, Lipoprotein lipase
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Disease relevance of Lpl


Psychiatry related information on Lpl


High impact information on Lpl

  • LPL induction of lipoprotein uptake significantly increased the rates of choline incorporation into phosphatidylcholine (PC) and disaturated PC, and these effects were associated with a three-fold increase in the activity of the rate-regulatory enzyme for PC synthesis, cytidylyltransferase [10].
  • Compared with native LPL, a fusion protein of glutathione S-transferase with the catalytically inactive carboxy-terminal domain of LPL did not activate CT despite inducing VLDL uptake [10].
  • First, transfection of CHO cells with expression vectors for several syndecan core proteins produced parallel increases in the cell association and degradation of lipoproteins enriched in lipoprotein lipase, a heparan-binding protein [11].
  • Administration of NO-1886 increased LPL enzyme mass in postheparin plasma and mRNA activity in epididymal adipose tissue, and it was concluded that the mode of action of this compound is stimulation of tissue LPL synthesis [12].
  • Administration of NO-1886 increased LPL activity in the postheparin plasma, adipose tissue, and myocardium of rats, and produced a reduction in plasma triglyceride levels with concomitant elevation of HDL cholesterol levels [12].

Chemical compound and disease context of Lpl


Biological context of Lpl

  • PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion [18].
  • These data suggest that lipolysis of triacylglycerol-rich chylomicron by LPL is necessary for postprandial vitamin E transport to the liver and subsequent transport to the other tissues [19].
  • Significantly greater activities of LPL, HSL, and LPL:HSL in adipose of MF rats suggested a greater capacity for fat accumulation which was not realized at the limited energy intake [20].
  • OVX-DHEA rats displayed a reduced adiposity and a lighter RP fat depot, which was associated with a decrease in LPL and an increase in HSL activities, compared to untreated OVX animals [21].
  • LPL activity was significantly increased at day 5 and remained elevated until day 14 of gestation [22].

Anatomical context of Lpl


Associations of Lpl with chemical compounds

  • These effects were consistent with increased LPL and HSL activities as well as respiration rates, mainly in response to exogenous palmitate [26].
  • RESULTS: Exposure to rosiglitazone for 24 h induced ucp-1, lpl and hsl gene expression and when rosiglitazone was combined with insulin a synergistic effect on lpl and ucp-3 mRNA expression was produced [26].
  • Colchicine injection was used as a tool to potentiate the increase in intracellular lipoprotein lipase (type L hormone-sensitive lipase) activity normally seen with fasting to determine if elevation of enzyme activity by this method produced a reduction in endogenous triacylglycerol (TG) in rat heart [23].
  • Because a similar mechanism of LPL regulation occurs in response to epinephrine, the absence of the translation repressor may be a mechanism for the loss of sensitivity of hypothyroid cells for catecholamines [1].
  • Translational regulation of lipoprotein lipase by thyroid hormone is via a cytoplasmic repressor that interacts with the 3' untranslated region [1].

Enzymatic interactions of Lpl


Regulatory relationships of Lpl


Other interactions of Lpl


Analytical, diagnostic and therapeutic context of Lpl


  1. Translational regulation of lipoprotein lipase by thyroid hormone is via a cytoplasmic repressor that interacts with the 3' untranslated region. Kern, P.A., Ranganathan, G., Yukht, A., Ong, J.M., Davis, R.C. J. Lipid Res. (1996) [Pubmed]
  2. Chronic effects of dehydroepiandrosterone on rat adipose tissue metabolism. Mauriège, P., Martel, C., Langin, D., Lacaille, M., Després, J.P., Bélanger, A., Labrie, F., Deshaies, Y. Metab. Clin. Exp. (2003) [Pubmed]
  3. Sciatic nerve lipoprotein lipase is reduced in streptozotocin-induced diabetes and corrected by insulin. Ferreira, L.D., Huey, P.U., Pulford, B.E., Ishii, D.N., Eckel, R.H. Endocrinology (2002) [Pubmed]
  4. Suppression of skeletal muscle lipoprotein lipase activity during physical inactivity: a molecular reason to maintain daily low-intensity activity. Bey, L., Hamilton, M.T. J. Physiol. (Lond.) (2003) [Pubmed]
  5. Resistance of adipose tissue lipoprotein lipase to insulin action in rats fed an obesity-promoting diet. Picard, F., Boivin, A., Lalonde, J., Deshaies, Y. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
  6. Spinal cord of the rat contains more lipoprotein lipase than other brain regions. Bessesen, D.H., Richards, C.L., Etienne, J., Goers, J.W., Eckel, R.H. J. Lipid Res. (1993) [Pubmed]
  7. The activities of lipoprotein lipase and of enzymes involved in triacylglycerol synthesis in rat adipose tissue. Effects of starvation, dietary modification and of corticotropin injection. Lawson, N., Pollard, A.D., Jennings, R.J., Gurr, M.I., Brindley, D.N. Biochem. J. (1981) [Pubmed]
  8. Macronutrient regulation of lipoprotein lipase is posttranslational. Erskine, J.M., Jensen, D.R., Eckel, R.H. J. Nutr. (1994) [Pubmed]
  9. Plasma triglyceride metabolism in humans and rats during aging and physical inactivity. Hamilton, M.T., Areiqat, E., Hamilton, D.G., Bey, L. International journal of sport nutrition and exercise metabolism. (2001) [Pubmed]
  10. Very low density lipoproteins stimulate surfactant lipid synthesis in vitro. Mallampalli, R.K., Salome, R.G., Bowen, S.L., Chappell, D.A. J. Clin. Invest. (1997) [Pubmed]
  11. The syndecan family of proteoglycans. Novel receptors mediating internalization of atherogenic lipoproteins in vitro. Fuki, I.V., Kuhn, K.M., Lomazov, I.R., Rothman, V.L., Tuszynski, G.P., Iozzo, R.V., Swenson, T.L., Fisher, E.A., Williams, K.J. J. Clin. Invest. (1997) [Pubmed]
  12. The novel compound NO-1886 increases lipoprotein lipase activity with resulting elevation of high density lipoprotein cholesterol, and long-term administration inhibits atherogenesis in the coronary arteries of rats with experimental atherosclerosis. Tsutsumi, K., Inoue, Y., Shima, A., Iwasaki, K., Kawamura, M., Murase, T. J. Clin. Invest. (1993) [Pubmed]
  13. Effects of hypothyroidism on the metabolism of lipid emulsion models of triacylglycerol-rich lipoproteins in rats. Redgrave, T.G., Elsegood, C.L., Mamo, J.C., Callow, M.J. Biochem. J. (1991) [Pubmed]
  14. Effect of diet on adipose tissue and skeletal muscle VLDL receptor and LPL: implications for obesity and hyperlipidemia. Roberts, C.K., Barnard, R.J., Liang, K.H., Vaziri, N.D. Atherosclerosis (2002) [Pubmed]
  15. NO-1886 (ibrolipim), a lipoprotein lipase-promoting agent, accelerates the expression of UCP3 messenger RNA and ameliorates obesity in ovariectomized rats. Kano, S., Doi, M. Metab. Clin. Exp. (2006) [Pubmed]
  16. Sex steroid influence on triglyceride metabolism. Kim, H.J., Kalkhoff, R.K. J. Clin. Invest. (1975) [Pubmed]
  17. Nitric oxide mediates endotoxin-induced hypertriglyceridemia through its action on skeletal muscle lipoprotein lipase. Picard, F., Kapur, S., Perreault, M., Marette, A., Deshaies, Y. FASEB J. (2001) [Pubmed]
  18. PPAR-gamma activation mediates adipose depot-specific effects on gene expression and lipoprotein lipase activity: mechanisms for modulation of postprandial lipemia and differential adipose accretion. Laplante, M., Sell, H., MacNaul, K.L., Richard, D., Berger, J.P., Deshaies, Y. Diabetes (2003) [Pubmed]
  19. Triton WR1339, an Inhibitor of Lipoprotein Lipase, Decreases Vitamin E Concentration in Some Tissues of Rats by Inhibiting Its Transport to Liver. Abe, C., Ikeda, S., Uchida, T., Yamashita, K., Ichikawa, T. J. Nutr. (2007) [Pubmed]
  20. The influence of dietary fat and meal frequency on lipoprotein lipase and hormone-sensitive lipase in rat adipose tissue. Paik, H.S., Yearick, E.S. J. Nutr. (1978) [Pubmed]
  21. Effect of a long-term percutaneous adrenal steroid treatment on rat adipose tissue metabolism. Mauriège, P., Langin, D., Montminy, V., Martel, C., Després, J.P., Bélanger, A., Labrie, F., Deshaies, Y. Int. J. Obes. Relat. Metab. Disord. (2000) [Pubmed]
  22. PPAR-gamma, TNF-alpha messenger RNA levels and lipase activity in the pregnant and lactating rat. Kawaguchi, K., Sugiyama, T., Hibasami, H., Toyoda, N. Life Sci. (2003) [Pubmed]
  23. Relationship between type L hormone-sensitive lipase activity and endogenous triacylglycerol in the hearts of colchicine-treated rats. Miller, W.C., Palmer, W.K., Oscai, L.B. Biochem. J. (1984) [Pubmed]
  24. A high glycemic index starch diet affects lipid storage-related enzymes in normal and to a lesser extent in diabetic rats. Kabir, M., Rizkalla, S.W., Quignard-Boulangé, A., Guerre-Millo, M., Boillot, J., Ardouin, B., Luo, J., Slama, G. J. Nutr. (1998) [Pubmed]
  25. Effects of ethanol intake on lipid metabolism in the lactating rat. do Carmo, M.G., do Nascimento, C.M., Martín-Hidalgo, A.M., Herrera, E. Alcohol (1996) [Pubmed]
  26. Rosiglitazone up-regulates lipoprotein lipase, hormone-sensitive lipase and uncoupling protein-1, and down-regulates insulin-induced fatty acid synthase gene expression in brown adipocytes of Wistar rats. Teruel, T., Hernandez, R., Rial, E., Martin-Hidalgo, A., Lorenzo, M. Diabetologia (2005) [Pubmed]
  27. cDNA cloning, tissue distribution, and identification of the catalytic triad of monoglyceride lipase. Evolutionary relationship to esterases, lysophospholipases, and haloperoxidases. Karlsson, M., Contreras, J.A., Hellman, U., Tornqvist, H., Holm, C. J. Biol. Chem. (1997) [Pubmed]
  28. Investigations into the actions of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1(7-36)amide on lipoprotein lipase activity in explants of rat adipose tissue. Knapper, J.M., Puddicombe, S.M., Morgan, L.M., Fletcher, J.M. J. Nutr. (1995) [Pubmed]
  29. Rat plasma VLDL composition and concentration and hepatic lipase and lipoprotein lipase activities are impaired during two types of protein malnutrition and unaffected by balanced refeeding. Lamri, M.Y., Meghelli-Bouchenak, M., Boualga, A., Belleville, J., Prost, J. J. Nutr. (1995) [Pubmed]
  30. Short-term effects of leptin on lipid metabolism in the rat. López-Soriano, J., Carbó, N., López-Soriano, F.J., Argilés, J.M. FEBS Lett. (1998) [Pubmed]
  31. Impaired beta-adrenergic receptor-mediated regulation of gene expression in adipocytes from older rats. Shilo, L., Chin, J.H., Hoffman, B.B. Am. J. Physiol. (1994) [Pubmed]
  32. Apolipoprotein E and lipoprotein lipase increase triglyceride-rich particle binding but decrease particle penetration in arterial wall. Mullick, A.E., Deckelbaum, R.J., Goldberg, I.J., Al-Haideri, M., Rutledge, J.C. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  33. Effects of a fish oil-lard diet on rat plasma lipoproteins, liver FAS, and lipolytic enzymes. Benhizia, F., Hainault, I., Serougne, C., Lagrange, D., Hajduch, E., Guichard, C., Malewiak, M.I., Quignard-Boulangé, A., Lavau, M., Griglio, S. Am. J. Physiol. (1994) [Pubmed]
  34. Effects of capsinoid on serum and liver lipids in hyperlipidemic rats. Tani, Y., Fujioka, T., Sumioka, M., Furuichi, Y., Hamada, H., Watanabe, T. J. Nutr. Sci. Vitaminol. (2004) [Pubmed]
  35. Lipoprotein lipase and hormone-sensitive lipase activity and mRNA in rat adipose tissue during pregnancy. Martin-Hidalgo, A., Holm, C., Belfrage, P., Schotz, M.C., Herrera, E. Am. J. Physiol. (1994) [Pubmed]
  36. Transforming growth factor-beta inhibits CCAAT/enhancer-binding protein expression and PPARgamma activity in unloaded bone marrow stromal cells. Ahdjoudj, S., Kaabeche, K., Holy, X., Fromigué, O., Modrowski, D., Zérath, E., Marie, P.J. Exp. Cell Res. (2005) [Pubmed]
  37. The metabolic "switch" AMPK regulates cardiac heparin-releasable lipoprotein lipase. An, D., Pulinilkunnil, T., Qi, D., Ghosh, S., Abrahani, A., Rodrigues, B. Am. J. Physiol. Endocrinol. Metab. (2005) [Pubmed]
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