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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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First established pregnancy and birth after ovarian stimulation with recombinant human follicle stimulating hormone (Org 32489).

This case report describes the first established pregnancy and birth after ovarian stimulation with Org 32489, pure recombinant human follicle stimulating hormone (recFSH, Organon International). A patient with tubal infertility participated in an open efficacy study of recFSH evaluating the efficacy of combined gonadotrophin- releasing hormone (GnRH)-agonist/recFSH treatment in women undergoing in-vitro fertilization ( IVF) and embryo transfer. Ovarian stimulation was induced by recFSH in association with buserelin (Suprecur, 4 x 150 micrograms/day) using a short protocol. After 9 days of recFSH treatment (75 IU/day), six pre-ovulatory follicles (> or = 15 mm) were observed and 10,000 IU human chorionic gonadotrophin were administered. Nine mature oocytes were retrieved by oocyte puncture and after IVF, three embryos were replaced in the uterus. A viable singleton intra-uterine pregnancy was revealed at a gestational age of 7 weeks. The pregnancy progressed normally and ended with a vaginal delivery at a gestational age of 39.5 weeks. A healthy girl was born and paediatric examination did not demonstrate any abnormality.[1]

References

  1. First established pregnancy and birth after ovarian stimulation with recombinant human follicle stimulating hormone (Org 32489). Devroey, P., Mannaerts, B., Smitz, J., Coelingh Bennink, H., Van Steirteghem, A. Hum. Reprod. (1993) [Pubmed]
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