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Chemical Compound Review

Allyloestrenol     (17R)-13-methyl-17-prop-2- enyl-2,3,6,7,8,9...

Synonyms: Gestanon-r, Perselin (TN), KST-1A4938, NSC37723, LS-64837, ...
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Disease relevance of allylestrenol

  • Plasma HIV-1 RNA was assessed by NASBA (nucleic acid sequence-based amplifications) (Organon Teknika, Boxtel, The Netherlands) with a detection limit of 80 copies/ml, whereas resistance was assessed by direct sequencing of the RT pol gene in patients with detectable viraemia, and by Antivirogram (Virco) in non-responder patients [1].
  • METHODS: One plasma sample from each individual was tested once by the Roche HIV monitor assay and once by the Organon nucleic acid sequence-based amplification (NASBA) HIV-1 RNA quantitative assay, according to the manufacturers' recommendations [2].
  • METHODS: To determine the clinical utility of a latex D-dimer assay (MDA D-Dimer; Organon Teknika Corporation, Durham, NC) in patients with suspected venous thromboembolism, we conducted a retrospective cohort study involving 595 unselected patients at 4 tertiary care hospitals [3].
  • The HTLV-I antibody titer was determined using the Vironstika HTLV-I/II Microelisa System (Organon Teknika) [4].
  • Using a photo-optical automated coagulation analyzer, the Organon Teknika MDA II, we have performed qualitative and quantitative aPTT waveform analysis and measured FVIII:C levels by automated one-stage aPTT clotting assay in 36 severely affected Hemophilia A patients [5].

Psychiatry related information on allylestrenol

  • Desglycinamide-9-arginine-8-vasopressin (DGAVP, Organon 5667) in patients with dementia [6].
  • The case control analysis did indicate a greater use of allylestrenol in the hypospadias group, but this difference was not statistically significant in the critical period for induction of hypospadias (ie, the third and fourth months of gestation) [7].
  • Prenatal treatment with these memory-related neuropeptides resulted in significant facilitation of learning/memory task performance in male and female mice treated with Organon 2766 (p less than 0.001), and a significant inhibition of learning/memory task performance in males and females treated with ACTH 1-24 (p less than 0.01) [8].
  • Forty-two patients aged between 19 and 70 years (30 women and 12 men) suffering from primary unipolar depression were randomly selected and treated under double-blind conditions with either mianserin (Lantanon; Organon) or clomipramine (Anafranil; Ciba-Geigy) after an initial wash-out period [9].

High impact information on allylestrenol


Chemical compound and disease context of allylestrenol

  • Five commercially available assays for hepatitis delta (HD) virus markers were compared for sensitivity, specificity, and reproducibility: three assays for antibody (anti-HD), provided by Diagnostics Pasteur, Organon Teknika, and Abbott Laboratories, and two assays for antigen (HD Ag), from Pasteur and Organon Teknika [15].
  • For detecting hepatitis delta virus antigen (HDAg), the Wellcome, Pasteur and Noctech assays had 100% sensitivity for all 42 HDAg-positive serum specimens that were confirmed in-house; the Organon reagents gave 59.5% sensitivity without detergent and 64.3% sensitivity with detergent, but there were 14 discrepant results with and without detergent [16].
  • Four adult men with Klinefelter's syndrome, low normal testosterone levels and normal sexual activity and interest were given testosterone undecanoate (TU 160 mg daily by mouth; Organon International) and placebo using a double blind cross-over design [17].
  • Specific binding sites for GnRH are present in myoma membranes, as 125I-Buserelin binding was displaced with equal efficiency by the superagonists, Buserelin and D-Trp6-GnRH, and by the antagonist Organon 30276, but not by unrelated peptides such as thyrotropin releasing hormone and oxytocin [18].
  • It follows that not only synthetic steroids (DES, allylestrenol), but also an excessive presence of the physiological steroid hormone during the critical period of receptor maturation can account for a decrease in uterine receptor concentration in adulthood [19].

Biological context of allylestrenol


Anatomical context of allylestrenol


Associations of allylestrenol with other chemical compounds

  • In the present study we compared the value of four novel latex DD tests (Tinaquant, Minutex, Ortho and SimpliRed) and one rapid ELISA (VIDAS) to a classical ELISA DD assay (Organon Mab Y18) in 132 patients suspected of DVT [29].
  • A double blind cross-over design was used comparing testosterone undecanoate (T.U., Organon International), 160 mg daily by mouth, with placebo [30].
  • Metabolism of Org 30659 ((17alpha)-17-hydroxy-11-methylene-19-norpregna-4, 15-dien-20-yn-3-one), a new potent progestagen currently under clinical development by NV Organon for use in oral contraception and hormone replacement therapy, was studied in vivo after oral administration to healthy postmenopausal women [31].
  • OBJECTIVE: Our purpose was to assess the efficacy of two recombinant follicle-stimulating hormones, follitropin beta (Follistim, Organon, West Orange, NJ) and follitropin alfa (Gonal F, Serono, Norwell, Mass) on pregnancy rates in varying age groups of women undergoing in vitro fertilization (IVF) [32].
  • The proliferation and differentiation of mast cells and Leydig cells were studied in adult sham operated or hypophysectomized rats after the administration of ethylene dimethane sulphonate (EDS) and in prepubertal rats after neonatal treatment with a gonadotropin-releasing hormone (GnRH) antagonist (Organon 30276; Oss, The Netherlands) [33].

Gene context of allylestrenol


Analytical, diagnostic and therapeutic context of allylestrenol

  • The hCG beta fragment was isolated from a partially purified commercial preparation of hCG (Organon) by gel filtration and immunoaffinity chromatography using monoclonal antibodies [38].
  • STUDY DESIGN AND METHODS: The sensitivity of the new LiaTek HIV III immunoblot assay (Organon Teknika, Turnhout, Belgium) was tested on 416 Western-blot positive samples (386 HIV-1, 22 HIV-2, 1 HIV-1/2, and 7 HIV-O) and on 45 HIV-1 seroconversion samples [39].
  • At a titer of 1:20 (n = 9), reactivity rates varied considerably among the tests, with only the RIPA and the Organon and Gull assays identifying reactive specimens [40].
  • To address this question, a controlled study was performed that examined the interinstrument variability of the INR on three separate Coagamate X2 coagulometers (Organon Teknika, Durham, NC) using the Simplastin Excel reagent (Organon Teknika) (International Sensitivity Index = 2.14) [41].
  • Neuromuscular block was measured using an acceleromyograph, the TOF-Watch-SX (NV Organon, Oss, The Netherlands) [42].


  1. Study on mutations and antiretroviral therapy (SMART): preliminary results. Gianotti, N., Moretti, F., Tambussi, G., Racca, S., Presi, S., Crucianelli, R., Carrera, P., Ferrari, M., Lazzarin, A. Antivir. Ther. (Lond.) (1999) [Pubmed]
  2. Subtype-specific problems with quantification of plasma HIV-1 RNA. Alaeus, A., Lidman, K., Sönnerborg, A., Albert, J. AIDS (1997) [Pubmed]
  3. A latex D-dimer reliably excludes venous thromboembolism. Bates, S.M., Grand'Maison, A., Johnston, M., Naguit, I., Kovacs, M.J., Ginsberg, J.S. Arch. Intern. Med. (2001) [Pubmed]
  4. Natural history of viral markers in children infected with human T lymphotropic virus type I in Jamaica. Maloney, E.M., Yamano, Y., Vanveldhuisen, P.C., Sawada, T., Kim, N., Cranston, B., Hanchard, B., Jacobson, S., Hisada, M. J. Infect. Dis. (2006) [Pubmed]
  5. The utility of activated partial thromboplastin time (aPTT) clot waveform analysis in the investigation of hemophilia A patients with very low levels of factor VIII activity (FVIII:C). Shima, M., Matsumoto, T., Fukuda, K., Kubota, Y., Tanaka, I., Nishiya, K., Giles, A.R., Yoshioka, A. Thromb. Haemost. (2002) [Pubmed]
  6. Desglycinamide-9-arginine-8-vasopressin (DGAVP, Organon 5667) in patients with dementia. Peabody, C.A., Thiemann, S., Pigache, R., Miller, T.P., Berger, P.A., Yesavage, J., Tinklenberg, J.R. Neurobiol. Aging (1985) [Pubmed]
  7. A case-control study to evaluate the risk of congenital anomalies as a result of allylestrenol therapy during pregnancy. Czeizel, A., Huiskes, N. Clinical therapeutics. (1988) [Pubmed]
  8. Pre- and postnatally administered ACTH, Organon 2766 and CRF facilitate or inhibit active avoidance task performance in young adult mice. Honour, L.C., White, M.H. Peptides (1988) [Pubmed]
  9. Mianserin and clomipramine in the treatment of depression. Levin, A. S. Afr. Med. J. (1982) [Pubmed]
  10. Effect of allyloestrenol on deteriorating uteroplacental circulation. Pearce, J.M., McParland, P., Steel, S.A., Huiskes, N. Lancet (1988) [Pubmed]
  11. Evaluation of six enzyme immunoassays for antibody against human immunodeficiency virus. Reesink, H.W., Lelie, P.N., Huisman, J.G., Schaasberg, W., Gonsalves, M., Aaij, C., Winkel, I.N., van der Does, J.A., Hekker, A.C., Desmyter, J. Lancet (1986) [Pubmed]
  12. Transplantation of hematopoietic stem cells obtained by a combined dye method fractionation of murine bone marrow. McAlister, I., Wolf, N.S., Pietrzyk, M.E., Rabinovitch, P.S., Priestley, G., Jaeger, B. Blood (1990) [Pubmed]
  13. Comparative evaluation of hepatitis C virus RNA quantitation by branched DNA, NASBA, and monitor assays. Lunel, F., Cresta, P., Vitour, D., Payan, C., Dumont, B., Frangeul, L., Reboul, D., Brault, C., Piette, J.C., Huraux, J.M. Hepatology (1999) [Pubmed]
  14. Does the type II glucocorticoid receptor mediate cortisol-induced suppression in pituitary responsiveness to gonadotropin-releasing hormone? Breen, K.M., Stackpole, C.A., Clarke, I.J., Pytiak, A.V., Tilbrook, A.J., Wagenmaker, E.R., Young, E.A., Karsch, F.J. Endocrinology (2004) [Pubmed]
  15. Evaluation of five hepatitis delta virus marker assays for detection of antigen and antibody. Bezeaud, A., Rosenswajg, M., Guillin, M.C. J. Clin. Microbiol. (1989) [Pubmed]
  16. Evaluation of commercial enzyme immunoassays for detection of hepatitis delta antigen and anti-hepatitis delta virus (HDV) and immunoglobulin M anti-HDV antibodies. Shattock, A.G., Morris, M.C. J. Clin. Microbiol. (1991) [Pubmed]
  17. The behavioural effects of testosterone undecanoate in adult men with Klinefelter's syndrome: a controlled study. Wu, F.C., Bancroft, J., Davidson, D.W., Nicol, K. Clin. Endocrinol. (Oxf) (1982) [Pubmed]
  18. Gonadotropin-releasing hormone specific binding sites in uterine leiomyomata. Wiznitzer, A., Marbach, M., Hazum, E., Insler, V., Sharoni, Y., Levy, J. Biochem. Biophys. Res. Commun. (1988) [Pubmed]
  19. Life-long effect of a single neonatal treatment with estradiol or progesterone on rat uterine estrogen receptor binding capacity. Csaba, G., Inczefi-Gonda, A. Horm. Metab. Res. (1992) [Pubmed]
  20. Successful use of the APTT in monitoring of the anti-factor Xa activity of the heparinoid organon 10172 in a case of HITS requiring open heart surgery. Marshall, L.R., Cannell, P.K., Herrmann, R.P. Thromb. Haemost. (1992) [Pubmed]
  21. Comparative effects of a new orally active antidysrhythmic agent, Organon 6001, on the cardiac action potential of human ventricular muscle and sheep Purkinje fibres [proceedings]. Kane, K.A. Br. J. Pharmacol. (1977) [Pubmed]
  22. Effect of tibolone on postmenopausal bone loss. Rymer, J., Chapman, M.G., Fogelman, I. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (1994) [Pubmed]
  23. Evaluation of Cobas Core Rubella IgG EIA recomb, a new enzyme immunoassay based on recombinant rubella-like particles. Grangeot-Keros, L., Pustowoit, B., Hobman, T. J. Clin. Microbiol. (1995) [Pubmed]
  24. Allylestrenol: three years of experience with Gestanon in threatened abortion and premature labor. Cortés-Prieto, J., Bosch, A.O., Rocha, J.A. Clinical therapeutics. (1980) [Pubmed]
  25. Releasing factors in the circumventricular organs in the rat brain. Kizer, J.S., Palkovits, M., Brownstein, M.J. Endocrinology (1976) [Pubmed]
  26. Evaluation of factor VIII deficient plasmas. Barrowcliffe, T.W., Tubbs, J.E., Wong, M.Y. Thromb. Haemost. (1993) [Pubmed]
  27. Discordant results in human chorionic gonadotropin assays. Cole, L.A., Kardana, A. Clin. Chem. (1992) [Pubmed]
  28. Comparison of Roche MONITOR and Organon Teknika NucliSens assays to quantify human immunodeficiency virus type 1 RNA in cerebrospinal fluid. Spearman, P., Fiscus, S.A., Smith, R.M., Shepard, R., Johnson, B., Nicotera, J., Harris, V.L., Clough, L.A., McKinsey, J., Haas, D.W. J. Clin. Microbiol. (2001) [Pubmed]
  29. Reliability of five rapid D-dimer assays compared to ELISA in the exclusion of deep venous thrombosis. Janssen, M.C., Heebels, A.E., de Metz, M., Verbruggen, H., Wollersheim, H., Janssen, S., Schuurmans, M.M., Nováková, I.R. Thromb. Haemost. (1997) [Pubmed]
  30. Androgen replacement with oral testosterone undecanoate in hypogonadal men: a double blind controlled study. Skakkebaek, N.E., Bancroft, J., Davidson, D.W., Warner, P. Clin. Endocrinol. (Oxf) (1981) [Pubmed]
  31. Excretion balance and metabolism of the progestagen Org 30659 in healthy postmenopausal women. Verhoeven, C.H., Gloudemans, R.H., Groothuis, G.M., Rietjens, I.M., Vos, R.M. J. Steroid Biochem. Mol. Biol. (2000) [Pubmed]
  32. Pregnancy rates in varying age groups after in vitro fertilization: a comparison of follitropin alfa (Gonal F) and follitropin beta (Follistim). Williams, R.S., Vensel, T., Sistrom, C.L., Kipersztok, S., Rhoton-Vlasak, A., Drury, K. Am. J. Obstet. Gynecol. (2003) [Pubmed]
  33. Simultaneous proliferation and differentiation of mast cells and Leydig cells in the rat testis. Are common regulatory factors involved? Gaytan, F., Aceitero, J., Lucena, C., Aguilar, E., Pinilla, L., Garnelo, P., Bellido, C. J. Androl. (1992) [Pubmed]
  34. Development of vimentin and glial fibrillary acidic protein immunoreactivities in the brain of gray mullet (Chelon labrosus), an advanced teleost. Arochena, M., Anadón, R., Díaz-Regueira, S.M. J. Comp. Neurol. (2004) [Pubmed]
  35. Identification of the human P450 enzymes involved in the in vitro metabolism of the synthetic steroidal hormones Org 4060 and Org 30659. Verhoeven, C.H., van Munster, T.T., Groothuis, G.M., Vos, R.M., Rietjens, I.M. Xenobiotica (2002) [Pubmed]
  36. Chemokine receptor CCR5 Delta 32 genetic analysis using multiple specimen types and the NucliSens Basic Kit. Tetali, S., Lee, E.M., Kaplan, M.H., Romano, J.W., Ginocchio, C.C. Clin. Diagn. Lab. Immunol. (2001) [Pubmed]
  37. AnergiX.RA Corixa. Prokaeva, T. Current opinion in investigational drugs (London, England : 2000) (2000) [Pubmed]
  38. Structure of the human chorionic gonadotropin beta-subunit fragment from pregnancy urine. Birken, S., Armstrong, E.G., Kolks, M.A., Cole, L.A., Agosto, G.M., Krichevsky, A., Vaitukaitis, J.L., Canfield, R.E. Endocrinology (1988) [Pubmed]
  39. Validation of a new immunoblot assay (LiaTek HIV III) for confirmation of human immunodeficiency virus infection. Zaaijer, H.L., van Rixel, G.A., Kromosoeto, J.N., Balgobind-Ramdas, D.R., Cuypers, H.T., Lelie, P.N. Transfusion (1998) [Pubmed]
  40. Serologic testing for Trypanosoma cruzi: comparison of radioimmunoprecipitation assay with commercially available indirect immunofluorescence assay, indirect hemagglutination assay, and enzyme-linked immunosorbent assay kits. Leiby, D.A., Wendel, S., Takaoka, D.T., Fachini, R.M., Oliveira, L.C., Tibbals, M.A. J. Clin. Microbiol. (2000) [Pubmed]
  41. Low interinstrument variability of the international normalized ratio with the coagamate X2/Simplastin excel system. Cunningham, M.T., Olson, J.D. Am. J. Clin. Pathol. (1996) [Pubmed]
  42. First human exposure of Org 25969, a novel agent to reverse the action of rocuronium bromide. Gijsenbergh, F., Ramael, S., Houwing, N., van Iersel, T. Anesthesiology (2005) [Pubmed]
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