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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins.

We have previously used exon amplification to identify the ADD1 gene in cosmid Y24 from the Huntington's disease ( HD) region of 4p16. 3. The same technique has now yielded a second gene from this cosmid. This gene appears to encode a novel member of a superfamily of transporter proteins that includes active and passive transporters in a number of species. The predicted protein of 455 amino acids displays sequence similarity with the E. coli tetracycline resistance efflux protein encoded by cloning vector pBR322, and with a number of related transporters. This gene should open a route to isolating additional mammalian members of this growing superfamily.[1]


  1. A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins. Duyao, M.P., Taylor, S.A., Buckler, A.J., Ambrose, C.M., Lin, C., Groot, N., Church, D., Barnes, G., Wasmuth, J.J., Housman, D.E. Hum. Mol. Genet. (1993) [Pubmed]
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