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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The mouse low density lipoprotein receptor gene: cDNA sequence and exon-intron structure.

The low density lipoprotein (LDL) receptor plays a central role in the cholesterol metabolism. The cDNA sequence of the mouse low density lipoprotein receptor (Ldlr) gene has been determined and shows 76% homology with the human gene. The exon-intron structure has been determined for the 129/J mouse strain. The gene is composed of 18 exons and spans a region of 28 kb. In addition, the promoter regions of the mouse and human genes are homologous. Northern blot analysis revealed an mRNA of approximately 5 kb. The cloning of the Ldlr gene will enhance the usefulness of the mouse for the study of cholesterol metabolism and, in particular, for carrying out gene targeting experiments.[1]


  1. The mouse low density lipoprotein receptor gene: cDNA sequence and exon-intron structure. Hoffer, M.J., van Eck, M.M., Petrij, F., van der Zee, A., de Wit, E., Meijer, D., Grosveld, G., Havekes, L.M., Hofker, M.H., Frants, R.R. Biochem. Biophys. Res. Commun. (1993) [Pubmed]
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