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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Photodegradation of benzydamine: phototoxicity of an isolated photoproduct on erythrocytes.

Benzydamine hydrochloride (Tantum, 1) is a photoallergic and phototoxic anti-inflammatory and analgesic agent. This drug is photolabile under aerobic and anaerobic conditions. Irradiation of a methanol solution of benzydamine under oxygen or argon at 300 nm affords 5-hydroxybenzydamine (2) and 2-beta-dimethylaminopropyl-1-benzylindalolin-3-one (3) as the main isolated and spectroscopically identified photoproducts. A radical intermediate was evidenced by thiobarbituric acid that was used as a radical sonde, as well as by the dimerization of cysteine. Erythrocyte lysis photosensitized by 1, 2, and 3 was investigated.[1]

References

  1. Photodegradation of benzydamine: phototoxicity of an isolated photoproduct on erythrocytes. Vargas, F., Rivas, C., Machado, R., Sarabia, Z. Journal of pharmaceutical sciences. (1993) [Pubmed]
 
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