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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation.

The proteins Grb2-Sem-5, Shc and Sos have been implicated in the signalling pathway from tyrosine kinase receptors to Ras. Grb2-Sem-5 binds directly to murine Sos1, a Ras exchange factor, through two SH3 domains. Sos is also associated with ligand- activated tyrosine kinase receptors which bind Grb2-Sem-5, and with the Grb2-Sem-5 binding protein, Shc. Ectopic expression of Drosophila Sos stimulates morphological transformation of rodent fibroblasts. These data define a pathway by which tyrosine kinases act through Ras to control cell growth and differentiation.[1]

References

  1. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Egan, S.E., Giddings, B.W., Brooks, M.W., Buday, L., Sizeland, A.M., Weinberg, R.A. Nature (1993) [Pubmed]
 
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