Gene Review:
Shc1 - src homology 2 domain-containing...
Mus musculus
Synonyms:
SH2 domain protein C1, SHC-transforming protein 1, SHC-transforming protein A, Shc, ShcA, ...
- Grb2 and Shc adapter proteins play distinct roles in Neu (ErbB-2)-induced mammary tumorigenesis: implications for human breast cancer. Dankort, D., Maslikowski, B., Warner, N., Kanno, N., Kim, H., Wang, Z., Moran, M.F., Oshima, R.G., Cardiff, R.D., Muller, W.J. Mol. Cell. Biol. (2001)
- Mechanism of the mitogenic effect of fluoride on osteoblast-like cells: evidences for a G protein-dependent tyrosine phosphorylation process. Caverzasio, J., Palmer, G., Suzuki, A., Bonjour, J.P. J. Bone Miner. Res. (1997)
- Sustained activation of MAPK/ERKs signaling pathway in cystic kidneys from bcl-2 -/- mice. Sorenson, C.M., Sheibani, N. Am. J. Physiol. Renal Physiol. (2002)
- Focal adhesion kinase enhances signaling through the Shc/extracellular signal-regulated kinase pathway in anaplastic astrocytoma tumor biopsy samples. Hecker, T.P., Grammer, J.R., Gillespie, G.Y., Stewart, J., Gladson, C.L. Cancer Res. (2002)
- Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc. Tarr, P.E., Roncarati, R., Pelicci, G., Pelicci, P.G., D'Adamio, L. J. Biol. Chem. (2002)
- Antagonism of p66shc by melanoma inhibitory activity. Kasuno, K., Naqvi, A., Dericco, J., Yamamori, T., Santhanam, L., Mattagajasingh, I., Yang, S., Meyskens, F.L., Bosserhoff, A.K., Irani, K. Cell Death Differ. (2007)
- Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Kousteni, S., Bellido, T., Plotkin, L.I., O'Brien, C.A., Bodenner, D.L., Han, L., Han, K., DiGregorio, G.B., Katzenellenbogen, J.A., Katzenellenbogen, B.S., Roberson, P.K., Weinstein, R.S., Jilka, R.L., Manolagas, S.C. Cell (2001)
- A signaling adapter function for alpha6beta4 integrin in the control of HGF-dependent invasive growth. Trusolino, L., Bertotti, A., Comoglio, P.M. Cell (2001)
- A requirement for caveolin-1 and associated kinase Fyn in integrin signaling and anchorage-dependent cell growth. Wary, K.K., Mariotti, A., Zurzolo, C., Giancotti, F.G. Cell (1998)
- The adaptor protein Shc couples a class of integrins to the control of cell cycle progression. Wary, K.K., Mainiero, F., Isakoff, S.J., Marcantonio, E.E., Giancotti, F.G. Cell (1996)
- A tyrosine-phosphorylated protein of 140 kD is constitutively associated with the phosphotyrosine binding domain of Shc and the SH3 domains of Grb2 in acute myeloid leukemia cells. Jücker, M., Schiffer, C.A., Feldman, R.A. Blood (1997)
- Rac is required for v-Abl tyrosine kinase to activate mitogenesis. Renshaw, M.W., Lea-Chou, E., Wang, J.Y. Curr. Biol. (1996)
- Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV. di Marzo Veronese, F., Copeland, T.D., DeVico, A.L., Rahman, R., Oroszlan, S., Gallo, R.C., Sarngadharan, M.G. Science (1986)
- ShcA and Grb2 mediate polyoma middle T antigen-induced endothelial transformation and Gab1 tyrosine phosphorylation. Ong, S.H., Dilworth, S., Hauck-Schmalenberger, I., Pawson, T., Kiefer, F. EMBO J. (2001)
- A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. Blaikie, P., Immanuel, D., Wu, J., Li, N., Yajnik, V., Margolis, B. J. Biol. Chem. (1994)
- c-Cbl is a suppressor of the neu oncogene. Levkowitz, G., Oved, S., Klapper, L.N., Harari, D., Lavi, S., Sela, M., Yarden, Y. J. Biol. Chem. (2000)
- The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway. Okada, S., Kao, A.W., Ceresa, B.P., Blaikie, P., Margolis, B., Pessin, J.E. J. Biol. Chem. (1997)
- Shc products are substrates of erbB-2 kinase. Segatto, O., Pelicci, G., Giuli, S., Digiesi, G., Di Fiore, P.P., McGlade, J., Pawson, T., Pelicci, P.G. Oncogene (1993)
- p120cbl is a major substrate of tyrosine phosphorylation upon B cell antigen receptor stimulation and interacts in vivo with Fyn and Syk tyrosine kinases, Grb2 and Shc adaptors, and the p85 subunit of phosphatidylinositol 3-kinase. Panchamoorthy, G., Fukazawa, T., Miyake, S., Soltoff, S., Reedquist, K., Druker, B., Shoelson, S., Cantley, L., Band, H. J. Biol. Chem. (1996)
- Taxol induces tyrosine phosphorylation of Shc and its association with Grb2 in murine RAW 264.7 cells. Wolfson, M., Yang, C.P., Horwitz, S.B. Int. J. Cancer (1997)
- Specificity of insulin-like growth factor I and insulin on Shc phosphorylation and Grb2 recruitment in caveolae. Biedi, C., Panetta, D., Segat, D., Cordera, R., Maggi, D. Endocrinology (2003)
- The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Lai, K.M., Pawson, T. Genes Dev. (2000)
- The mammalian ShcB and ShcC phosphotyrosine docking proteins function in the maturation of sensory and sympathetic neurons. Sakai, R., Henderson, J.T., O'Bryan, J.P., Elia, A.J., Saxton, T.M., Pawson, T. Neuron (2000)
- A mammalian adaptor protein with conserved Src homology 2 and phosphotyrosine-binding domains is related to Shc and is specifically expressed in the brain. O'Bryan, J.P., Songyang, Z., Cantley, L., Der, C.J., Pawson, T. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Fyn and JAK2 mediate Ras activation by reactive oxygen species. Abe, J., Berk, B.C. J. Biol. Chem. (1999)
- Embryonic and hematopoietic stem cells express a novel SH2-containing inositol 5'-phosphatase isoform that partners with the Grb2 adapter protein. Tu, Z., Ninos, J.M., Ma, Z., Wang, J.W., Lemos, M.P., Desponts, C., Ghansah, T., Howson, J.M., Kerr, W.G. Blood (2001)
- Cloning and characterization of mPAL, a novel Shc SH2 domain-binding protein expressed in proliferating cells. Schmandt, R., Liu, S.K., McGlade, C.J. Oncogene (1999)
- Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling. Faisal, A., el-Shemerly, M., Hess, D., Nagamine, Y. J. Biol. Chem. (2002)
- The oncogenic versions of the Ret and Trk tyrosine kinases bind Shc and Grb2 adaptor proteins. Borrello, M.G., Pelicci, G., Arighi, E., De Filippis, L., Greco, A., Bongarzone, I., Rizzetti, M., Pelicci, P.G., Pierotti, M.A. Oncogene (1994)
- Immunohistochemical evidence of seizure-induced activation of trkB receptors in the mossy fiber pathway of adult mouse hippocampus. He, X.P., Minichiello, L., Klein, R., McNamara, J.O. J. Neurosci. (2002)
- Identification of cadherin tyrosine residues that are phosphorylated and mediate Shc association. Xu, Y., Carpenter, G. J. Cell. Biochem. (1999)
- Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation. Klint, P., Kanda, S., Kloog, Y., Claesson-Welsh, L. Oncogene (1999)
- Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Ravichandran, K.S., Igras, V., Shoelson, S.E., Fesik, S.W., Burakoff, S.J. Proc. Natl. Acad. Sci. U.S.A. (1996)
- The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation. Ravichandran, K.S., Burakoff, S.J. J. Biol. Chem. (1994)
- Catalytic activity of the mouse guanine nucleotide exchanger mSOS is activated by Fyn tyrosine protein kinase and the T-cell antigen receptor in T cells. Li, B., Subleski, M., Fusaki, N., Yamamoto, T., Copeland, T., Princler, G.L., Kung, H., Kamata, T. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Non-redundant role of Shc in Erk activation by cytoskeletal reorganization. Faisal, A., Kleiner, S., Nagamine, Y. J. Biol. Chem. (2004)
- Adenovirus-mediated overexpression of IRS-1 interacting domains abolishes insulin-stimulated mitogenesis without affecting glucose transport in 3T3-L1 adipocytes. Sharma, P.M., Egawa, K., Gustafson, T.A., Martin, J.L., Olefsky, J.M. Mol. Cell. Biol. (1997)
- Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways. Kao, A.W., Waters, S.B., Okada, S., Pessin, J.E. Endocrinology (1997)
- Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Klein, N.P., Schneider, R.J. Mol. Cell. Biol. (1997)
- Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors. Lannutti, B.J., Drachman, J.G. Blood (2004)
- Impaired Shc, Ras, and MAPK activation but normal Akt activation in FL5.12 cells expressing an insulin-like growth factor I receptor mutated at tyrosines 1250 and 1251. Leahy, M., Lyons, A., Krause, D., O'Connor, R. J. Biol. Chem. (2004)
- Systematic mapping of potential binding sites for Shc and Grb2 SH2 domains on insulin receptor substrate-1 and the receptors for insulin, epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor. Ward, C.W., Gough, K.H., Rashke, M., Wan, S.S., Tribbick, G., Wang, J. J. Biol. Chem. (1996)
- Distribution of the src-homology-2-domain-containing inositol 5-phosphatase SHIP-2 in both non-haemopoietic and haemopoietic cells and possible involvement of SHIP-2 in negative signalling of B-cells. Muraille, E., Pesesse, X., Kuntz, C., Erneux, C. Biochem. J. (1999)
- SU6656, a selective src family kinase inhibitor, used to probe growth factor signaling. Blake, R.A., Broome, M.A., Liu, X., Wu, J., Gishizky, M., Sun, L., Courtneidge, S.A. Mol. Cell. Biol. (2000)