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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The effect of aortic coarctation on expression of endothelin-1 and endothelin receptors in heart and lungs.

Expression of prepro-endothelin-1 (ppET-1), and endothelin (ET) receptor subtype (ETA, ETB) mRNAs was studied in atria, ventricles, and lungs of aortic coarctated rats. During 8 weeks following aortic banding, rats developed ventricular hypertrophy. The levels of expression of ppET-1, ETA- and ETB-receptors were significantly lower in the ventricles of coarctated rats than in sham-operated animals. In atria, the level of expression of ppET-1, ETA and ETB-receptors was not significantly changed. These results indicate that production of ET-1 is decreased and ETA and ETB-receptors are down-regulated in hypertrophied ventricles 8 weeks after aortic coarctation. This may be a compensatory response to pressure overload.[1]

References

  1. The effect of aortic coarctation on expression of endothelin-1 and endothelin receptors in heart and lungs. Sirviö, M.L., Uhlenius, N., Stewen, P., Metsärinne, K., Fyhrquist, F. Blood Press. (1995) [Pubmed]
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