The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Ednrb  -  endothelin receptor type B

Rattus norvegicus

Synonyms: ET-B, ET-BR, Ednra, Endothelin B receptor, Endothelin receptor non-selective type, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ednrb


High impact information on Ednrb

  • Ednrb-deficient gut neural crest stem cells (NCSCs) were reduced to 40% of wild-type levels by embryonic day 12.5 (E12.5), but no further depletion of NCSCs was subsequently observed [6].
  • Loss of Endothelin-3/Endothelin receptor B (EDNRB) signaling leads to aganglionosis of the distal gut (Hirschsprung's disease), but it is unclear whether it is required primarily for neural crest progenitor maintenance or migration [6].
  • The DbetaH-EDNRB transgene compensates for deficient endogenous EDNRB in these rats and prevents the intestinal defect [7].
  • We used the human dopamine-beta-hydroxylase (DbetaH) promoter to direct transgenic expression of EDNRB to colonizing ENS precursors in the sl/sl rat [7].
  • The transgene has no effect on coat color spotting, indicating the critical time for EDNRB expression in enteric nervous system development begins after separation of the melanocyte lineage from the ENS lineage and their common precursor [7].

Chemical compound and disease context of Ednrb


Biological context of Ednrb


Anatomical context of Ednrb


Associations of Ednrb with chemical compounds

  • Endothelin (ET)-3 stimulates cyclic guanosine 3',5'-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells [17].
  • Secretion of the natriuretic peptides was blocked by BQ-123, an ETA-receptor antagonist, but was not affected by either IRL-1620 or [Ala1,3,11,15]ET-1, two ETB-receptor agonists [19].
  • However, in the presence of U-73122, the selective stimulation of ETB receptors induced the mobilization of a thapsigargin-sensitive and inositol phosphate-independent intracellular Ca2+ pool [13].
  • To identify the nature of the guanine nucleotide regulatory proteins (G protein(s)) coupling ETB receptors to each effector, we used antibodies against the COOH terminus of different G protein alpha subunits [15].
  • Rats were fed a K(+)-deficient diet alone (LC) or with an ETA-selective antagonist ABT-627 (LA) or an ETB-selective antagonist A-192621 (LB) for 8 wk [20].

Physical interactions of Ednrb

  • Although it is commonly accepted that endothelin-1 binding to endothelial cell ETB receptors stimulates nitric oxide (NO) synthesis and subsequent smooth muscle relaxation, the signaling pathways downstream of ETB receptor activation are unknown [14].
  • The three monoiodo ET-3 derivatives bound to recombinant rat ETB receptors with a pM affinity [21].
  • Quantitative autoradiography showed that ET-1[1-21] displaced both [(125)I]PD-151242 binding to ETA receptors and [(125)I]BQ-3020 binding to ETB receptors in both rat ZG and adrenal medulla, while ET-1[1-31] displaced only [(125)I]BQ-3020 binding [22].

Regulatory relationships of Ednrb

  • We conclude that ET-3 stimulates NO-induced cGMP generation through ETB receptor in glomerulus [17].
  • The ETB receptor stimulates activation of the extracellular regulated kinase 2 (ERK2), which is thought to be required for proliferation of ASM cells [23].
  • These results suggest that activation of brain ETB receptors induced GDNF and BDNF expression in astrocytes [24].
  • Treatment with bosentan or ET-A receptor antagonist largely prevented the colitis-induced reduction in blood flow and tissue injury whereas ET-B receptor antagonist did not attenuate tissue injury or reductions in blood flow [25].
  • Hypoxia-induced reactive oxygen species downregulate ETB receptor-mediated contraction of rat pulmonary arteries [26].

Other interactions of Ednrb

  • From these results, mesangial ETB receptor may work to counteract the vasoconstrictive effect of endothelin caused via ETA receptor in glomerulus [17].
  • ETB receptor agonist IRL 1620 produced cGMP in a dose-dependent manner, mimicking the effect of ET-3 [17].
  • Functional link between ETB receptors and eNOS maintain tissue oxygenation in the normal liver [27].
  • Therefore, chronic PPAR-alpha agonist treatment reduces salt-dependent hypertension produced by ETB receptor blockade in male and female Sprague-Dawley rats [9].
  • Taken together, the data elucidate a G-protein-coupled receptor signaling pathway for ETB receptor-mediated NO production and call attention to the absolute requirement for heterotrimeric G-protein betagamma subunits in this cascade [14].

Analytical, diagnostic and therapeutic context of Ednrb

  • Northern blot analysis of both ETA- and ETB-receptor mRNAs allowed only the detection of the former, indicating that the ETB receptor may be expressed in very small amounts [19].
  • A parallel but marked increase in ETA and ETB receptor mRNAs compared with preproET-1 and -3 messages was observed after angioplasty [28].
  • Retrograde perfusion suggests that ETB receptors are located arterially whereas ETA receptors are predominantly venous in distribution.(ABSTRACT TRUNCATED AT 250 WORDS)[29]
  • The most likely explanation is upregulation of functional ETA receptors after I/R because ETB-receptor stimulation did not cause coronary constriction in this preparation [30].
  • Although mRNA transcripts specific for both ETA and ETB receptors were found by RT-PCR, the ETA mRNA was more abundant [31].


  1. Renal endothelin receptor type B upregulation in rats with low or high renin hypertension. Brakch, N., Abdel-Sayed, S., Allemandou, F., Wang, Q., Aubert, J.F., Brunner, H.R., Nussberger, J. J. Hypertens. (2004) [Pubmed]
  2. Role of endothelin in mediating neurogenic plasma extravasation in rat dura mater. Brändli, P., Löffler, B.M., Breu, V., Osterwalder, R., Maire, J.P., Clozel, M. Pain (1996) [Pubmed]
  3. Pharmacology of a non-selective ETA and ETB receptor antagonist, TAK-044 and the inhibition of myocardial infarct size in rats. Watanabe, T., Awane, Y., Ikeda, S., Fujiwara, S., Kubo, K., Kikuchi, T., Kusumoto, K., Wakimasu, M., Fujino, M. Br. J. Pharmacol. (1995) [Pubmed]
  4. Endothelin-1-evoked calcium transients in UMR-106 osteoblastic osteosarcoma cells are mediated through endothelin-A and endothelin-B receptors. Semler, D.E., Ohlstein, E.H., Nambi, P., Slater, C., Stern, P.H. J. Pharmacol. Exp. Ther. (1995) [Pubmed]
  5. The endothelin system in Morris hepatoma-7777: an endothelin receptor antagonist inhibits growth in vitro and in vivo. Pfab, T., Stoltenburg-Didinger, G., Trautner, C., Godes, M., Bauer, C., Hocher, B. Br. J. Pharmacol. (2004) [Pubmed]
  6. Temporally distinct requirements for endothelin receptor B in the generation and migration of gut neural crest stem cells. Kruger, G.M., Mosher, J.T., Tsai, Y.H., Yeager, K.J., Iwashita, T., Gariepy, C.E., Morrison, S.J. Neuron (2003) [Pubmed]
  7. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease. Gariepy, C.E., Williams, S.C., Richardson, J.A., Hammer, R.E., Yanagisawa, M. J. Clin. Invest. (1998) [Pubmed]
  8. Role of endothelin-1/endothelin receptor system in endotoxic shock rats. Ishimaru, S., Shichiri, M., Mineshita, S., Hirata, Y. Hypertens. Res. (2001) [Pubmed]
  9. Peroxisome proliferator-activated receptor-alpha activation reduces salt-dependent hypertension during chronic endothelin B receptor blockade. Williams, J.M., Zhao, X., Wang, M.H., Imig, J.D., Pollock, D.M. Hypertension (2005) [Pubmed]
  10. Endothelin-1 is involved in norepinephrine-induced ventricular hypertrophy in vivo. Acute effects of bosentan, an orally active, mixed endothelin ETA and ETB receptor antagonist. Kaddoura, S., Firth, J.D., Boheler, K.R., Sugden, P.H., Poole-Wilson, P.A. Circulation (1996) [Pubmed]
  11. Modulation of glomerular endothelin and endothelin receptor gene expression in aminonucleoside-induced nephrosis. Nakamura, T., Ebihara, I., Fukui, M., Osada, S., Tomino, Y., Masaki, T., Goto, K., Furuichi, Y., Koide, H. J. Am. Soc. Nephrol. (1995) [Pubmed]
  12. Tezosentan, an endothelin receptor antagonist, limits liver injury in endotoxin challenged cirrhotic rats. Urbanowicz, W., Sogni, P., Moreau, R., Tazi, K.A., Barriere, E., Poirel, O., Martin, A., Guimont, M.C., Cazals-Hatem, D., Lebrec, D. Gut (2004) [Pubmed]
  13. Dual control of seminiferous tubule contractility mediated by ETA and ETB endothelin receptor subtypes. Tripiciano, A., Palombi, F., Ziparo, E., Filippini, A. FASEB J. (1997) [Pubmed]
  14. Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt. Liu, S., Premont, R.T., Kontos, C.D., Huang, J., Rockey, D.C. J. Biol. Chem. (2003) [Pubmed]
  15. Coupling of endothelin B receptors to the calcium pump and phospholipase C via Gs and Gq in rat liver. Jouneaux, C., Mallat, A., Serradeil-Le Gal, C., Goldsmith, P., Hanoune, J., Lotersztajn, S. J. Biol. Chem. (1994) [Pubmed]
  16. Receptor- and non-receptor-mediated clearance of big-endothelin and endothelin-1: differential effects of acute and chronic ETA receptor blockade. Burkhardt, M., Barton, M., Shaw, S.G. J. Hypertens. (2000) [Pubmed]
  17. Endothelin (ET)-3 stimulates cyclic guanosine 3',5'-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells. Owada, A., Tomita, K., Terada, Y., Sakamoto, H., Nonoguchi, H., Marumo, F. J. Clin. Invest. (1994) [Pubmed]
  18. Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1. Housset, C., Rockey, D.C., Bissell, D.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  19. Endothelin-stimulated secretion of natriuretic peptides by rat atrial myocytes is mediated by endothelin A receptors. Thibault, G., Doubell, A.F., Garcia, R., Larivière, R., Schiffrin, E.L. Circ. Res. (1994) [Pubmed]
  20. Endothelin a receptor blockade and endothelin B receptor blockade improve hypokalemic nephropathy by different mechanisms. Suga, S., Yasui, N., Yoshihara, F., Horio, T., Kawano, Y., Kangawa, K., Johnson, R.J. J. Am. Soc. Nephrol. (2003) [Pubmed]
  21. High affinity interaction of endothelin-3 with recombinant ETA receptors. Desmarets, J., Frelin, C. Biochem. Biophys. Res. Commun. (1999) [Pubmed]
  22. Endothelin-1[1-31], acting as an ETA-receptor selective agonist, stimulates proliferation of cultured rat zona glomerulosa cells. Mazzocchi, G., Rossi, G.P., Malendowicz, L.K., Champion, H.C., Nussdorfer, G.G. FEBS Lett. (2000) [Pubmed]
  23. Endothelin-stimulated ERK activation in airway smooth-muscle cells requires calcium influx and Raf activation. Vichi, P., Whelchel, A., Knot, H., Nelson, M., Kolch, W., Posada, J. Am. J. Respir. Cell Mol. Biol. (1999) [Pubmed]
  24. Intracerebroventricular administration of an endothelin ETB receptor agonist increases expressions of GDNF and BDNF in rat brain. Koyama, Y., Tsujikawa, K., Matsuda, T., Baba, A. Eur. J. Neurosci. (2003) [Pubmed]
  25. Blood flow alterations in TNBS-induced colitis: role of endothelin receptors. Deniz, M., Cetinel, S., Kurtel, H. Inflamm. Res. (2004) [Pubmed]
  26. Hypoxia-induced reactive oxygen species downregulate ETB receptor-mediated contraction of rat pulmonary arteries. Wang, X., Tong, M., Chinta, S., Raj, J.U., Gao, Y. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  27. Functional link between ETB receptors and eNOS maintain tissue oxygenation in the normal liver. Paxian, M., Keller, S.A., Baveja, R., Korneszczuk, K., Huynh, T.T., Clemens, M.G. Microcirculation (New York, N.Y. : 1994) (2004) [Pubmed]
  28. Expression of endothelin-1, endothelin-3, endothelin-converting enzyme-1, and endothelin-A and endothelin-B receptor mRNA after angioplasty-induced neointimal formation in the rat. Wang, X., Douglas, S.A., Louden, C., Vickery-Clark, L.M., Feuerstein, G.Z., Ohlstein, E.H. Circ. Res. (1996) [Pubmed]
  29. Actions of endothelins and sarafotoxin 6c in the rat isolated perfused lung. Lal, H., Woodward, B., Williams, K.I. Br. J. Pharmacol. (1995) [Pubmed]
  30. Responses to endothelins-1, -2, and -3 and sarafotoxin 6c after ischemia/reperfusion in isolated perfused rat heart: role of vasodilator loss. Thompson, M., Westwick, J., Woodward, B. J. Cardiovasc. Pharmacol. (1995) [Pubmed]
  31. Endothelin 1 receptors, signal transduction and effects on DNA and proteoglycan synthesis in rat articular chondrocytes. Khatib, A.M., Lomri, A., Moldovan, F., Soliman, H., Fiet, J., Mitrovic, D.R. Cytokine (1998) [Pubmed]
WikiGenes - Universities