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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Human natural killer cell inhibitory receptors bind to HLA class I molecules.

To obtain direct evidence that human natural killer cell (NK) inhibitory receptors physically interact with polymorphic determinants of major histocompatibility complex class I molecules, a receptor termed NK-associated transcript-2 has been produced as a soluble fusion protein with the human IgG1 Fc portion. This soluble receptor binds specifically to HLA-C alleles with serine 77 and asparagine 80 in cell adhesion assays.[1]

References

  1. Human natural killer cell inhibitory receptors bind to HLA class I molecules. Döhring, C., Colonna, M. Eur. J. Immunol. (1996) [Pubmed]
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