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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Sequence variation of latent membrane protein-1 of Epstein-Barr virus strains associated with hairy leukoplakia.

The Epstein-Barr virus (EBV) latent membrane protein (LMP)-1 is expressed in hairy leukoplakia ( HL), but data on LMP-1 sequence variation of HL isolates are limited. Variation in the LMP-1 repeat region and presence of a 30-nt deletion were studied using DNA scrapings from 28 HL lesions. cDNAs from 3 different HL isolates were sequenced, 2 from lymphocyte cell lines (LCLs) generated using HL biopsy material. The deletion was found in 16 (57%) of 28 HL scraping, and multiple repeat region variants were seen in 13 scrapings (46%). HL LMP sequence were similar to those described in nasopharyngeal cancer and lymphoma tissues, including two motifs of four amino acid changes relative to B95-8 upstream and downstream of the repeat region, respectively. Generation of LCLs using HL biopsy material confirmed the ability of HL EBV strains to infect and transform lymphocytes.[1]

References

  1. Sequence variation of latent membrane protein-1 of Epstein-Barr virus strains associated with hairy leukoplakia. Palefsky, J.M., Berline, J., Penaranda, M.E., Lennette, E.T., Greenspan, D., Greenspan, J.S. J. Infect. Dis. (1996) [Pubmed]
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