Disease relevance of Nasopharyngeal Neoplasms

• HL LMP sequence were similar to those described in nasopharyngeal cancer and lymphoma tissues, including two motifs of four amino acid changes relative to B95-8 upstream and downstream of the repeat region, respectively [1].
• Because the most common type of nasopharyngeal cancer (NPC), squamous cell carcinoma, is related to smoking, we sought to determine whether GSTM1 is associated with risk for NPC [2].
• These preliminary data indicate that the combination of paclitaxel and carboplatin is active against advanced head and neck cancer, particularly when used in the treatment of nasopharyngeal cancer [3].
• We present our cases of recurrent pituitary hemangiopericytoma, radiation-induced recurrent meningioma, recurrent clival chordoma, recurrent nasopharyngeal cancer involving the cavernous sinus, and recurrent parotid carcinoma of the skull base which were all successfully retreated with high-activity 125iodine (I-125) permanent implantation [4].
• We describe the case of a man with dermatomyositis and stage IV nasopharyngeal cancer treated with chemoradiotherapy and s.c. amifostine [5].

High impact information on Nasopharyngeal Neoplasms

• Formaldehyde exposure and nasopharyngeal cancer: re-examination of the National Cancer Institute Study and an update of one plant [6].
• PURPOSE: To evaluate the feasibility and efficacy of concomitant boost radiotherapy (RT) plus cisplatin-based chemotherapy compared with standard fractionation RT for patients with advanced nasopharyngeal cancer [7].
• Adjuvant chemotherapy with vincristine, cyclophosphamide, and doxorubicin after radiotherapy in local-regional nasopharyngeal cancer: results of a 4-year multicenter randomized study [8].
• This current study evaluates the efficacy of combining systemically delivered Bcl-2 phosphorothioate antisense (Bcl-2 ASO) and radiation for nasopharyngeal cancer therapy [9].
• Identification of serum amyloid a protein as a potentially useful biomarker to monitor relapse of nasopharyngeal cancer by serum proteomic profiling [10].

Chemical compound and disease context of Nasopharyngeal Neoplasms

• CONCLUSION: Concomitant boost RT with cisplatin-based chemotherapy is feasible and improves local-regional control as well as survival for patients with advanced nasopharyngeal cancer compared with standard RT alone [7].
• Our study suggests that except for smoking and chlorophenol exposure, which are associated with both sites, the risk factor profiles may differ between sinonasal and nasopharyngeal cancers [11].
• A Bayesian re-assessment of two Phase II trials of gemcitabine in metastatic nasopharyngeal cancer [12].
• Nasopharyngeal cancer: a review of 1605 patients treated radically with cobalt 60 [13].
• Permanent iodine-125 (I-125) boost implants after external radiation therapy in nasopharyngeal cancer [14].

Biological context of Nasopharyngeal Neoplasms

• Occupational exposure to chlorophenol and the risk of nasal and nasopharyngeal cancers among U.S. men aged 30 to 60 [15].
• Our study suggests that the immunological functions and apoptosis related gene expression in the carcinoma cells may be used as prognostic factors and help in the decision of therapy of patients with nasopharyngeal cancer [16].
• Differential expression of metallothionein isoforms in nasopharyngeal cancer and inhibition of cell growth by antisense down-regulation of metallothionein-2A [17].
• MATERIALS AND METHODS: We performed a database search maintained by the Department of Radiation Oncology of Hacettepe University School of Medicine for patients with nasopharyngeal cancer who were </=30 years old at presentation [18].

Anatomical context of Nasopharyngeal Neoplasms

• In this study, we studied two nasopharyngeal cancer cell lines with a four-fold difference in sensitivity to cisplatin [19].
• There have been no cases of nasopharyngeal cancer in the cohort compared with an estimated 1.3 expected--which gives no support to the findings in a similarly designed study in the United States of an excess of cancers of the nasopharynx associated with exposure to formaldehyde [20].

Gene context of Nasopharyngeal Neoplasms

• Telomerase is regulated by protein kinase C-zeta in human nasopharyngeal cancer cells [21].
• In this study, using MRP overexpressing multidrug resistant nasopharyngeal cancer cells, we examined the expression of apoptosis related genes including p53, p21WAF1, bax and bcl-Xs between drug sensitive KB and its resistant KB/7D cells [22].
• CONCLUSIONS: Nasopharyngeal cancer may be a useful target for selective COX-2 inhibition [23].
• Cdc42/Rac1 participates in the control of telomerase activity in human nasopharyngeal cancer cells [24].
• Overexpression of the R2 subunit of ribonucleotide reductase in human nasopharyngeal cancer cells reduces radiosensitivity [25].

Analytical, diagnostic and therapeutic context of Nasopharyngeal Neoplasms

• In the epidemiologic studies, there was sufficient evidence that formaldehyde causes nasopharyngeal cancer, "strong but not sufficient" evidence of leukemia, and limited evidence of sinonasal cancer [26].
• Expression of Y-Box binding protein-1 following hypericin-mediated photodynamic therapy in well-differentiated nasopharyngeal cancer in vivo [27].
• Inhibition of growth of human nasopharyngeal cancer xenografts in SCID mice by arsenic trioxide [28].

References