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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Growth suppression of a cervical cancer cell line (TMCC-1) by the human wild-type p53 gene.

To investigate the effects of human wild-type p53 expression on the proliferation of cervical carcinoma cells, a plasmid, pMO7-hp53, which contains a full-length cDNA of the human wild-type p53 (wt-p53) gene, was transfected into a cell line (TMCC-1) derived from an endocervical type, human papilloma virus-positive adenocarcinoma of the uterine cervix. The exogenous wt- p53 expression induced growth suppression, morphological changes, and loss of anchorage-independent growth of the tumor cells. As the wt- p53 gene apparently plays a negative role in growth regulation of cervical carcinoma cells, this gene may possibly be of some use for treating subjects with a cervical carcinoma.[1]

References

  1. Growth suppression of a cervical cancer cell line (TMCC-1) by the human wild-type p53 gene. Zheng, P.S., Iwasaka, T., Ouchida, M., Fukuda, K., Yokoyama, M., Sugimori, H. Gynecol. Oncol. (1996) [Pubmed]
 
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