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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Crystal structure of a human TATA box-binding protein/TATA element complex.

The TATA box-binding protein ( TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.[1]


  1. Crystal structure of a human TATA box-binding protein/TATA element complex. Nikolov, D.B., Chen, H., Halay, E.D., Hoffman, A., Roeder, R.G., Burley, S.K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
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