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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro.

The antibacterial effects of omeprazole (100, 200 and 300 mg/L) were assessed using bacterial growth curves. A dose-related permanent inhibition was seen with actively growing Gram-positive cocci. A reduced and only temporary effect was observed with Gram-negative bacilli. After 1 day the bacterial count of Helicobacter pylori in the presence of omeprazole 200 mg/L was reduced from 10(4) cfu/mL for the control to zero. No synergic or antagonistic interaction of omeprazole with amoxycillin or doxycycline was observed for Escherichia coli and Enterococcus faecalis.[1]

References

  1. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. Jonkers, D., Stobberingh, E., Stockbrügger, R. J. Antimicrob. Chemother. (1996) [Pubmed]
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