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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effect of aluminum on hematopoiesis after intraperitoneal exposure in rats.

The experiments were performed on female Wistar rats that received aluminum chloride every day intraperitoneally, 4 mg Al/kg for 3 weeks. In the blood selected morphological factors and delta-aminolevulinic acid dehydratase activity (ALA-D) were investigated. In the kidney and liver ALA-D, delta-aminolevulinic acid synthase (ALA-S), and heme oxygenase activity were also determined. After aluminum chloride administration the most sensitive indicator was an increase of heme oxygenase activity in the liver and a decrease in iron levels in the serum of rats. Aluminum also increased ALA-S activity in the kidney and liver of rats. No changes of ALA-D activity in the liver, the kidney, and the blood were observed. The decreasing of hemoglobin, hematocrit, mean corpuscular hemoglobin mass, and mean corpuscular hemoglobin concentration was noted after 3 weeks of exposure.[1]


  1. Effect of aluminum on hematopoiesis after intraperitoneal exposure in rats. Chmielnicka, J., Nasiadek, M., Lewandowska-Zyndul, E., Pińkowski, R. Ecotoxicol. Environ. Saf. (1996) [Pubmed]
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