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Alad  -  aminolevulinate dehydratase

Rattus norvegicus

Synonyms: ALADH, ALADR, Delta-aminolevulinic acid dehydratase, Porphobilinogen synthase, aminolevulinatedelta-dehydratase
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  2. The phylogenetically conserved histidines of Escherichia coli porphobilinogen synthase are not required for catalysis. Mitchell, L.W., Volin, M., Jaffe, E.K. J. Biol. Chem. (1995) [Pubmed]
  3. Influence of dietary selenium on lead toxicity in the rat. Cerklewski, F.L., Forbes, R.M. J. Nutr. (1976) [Pubmed]
  4. Is delta-aminolevulinic acid dehydratase rate limiting in heme biosynthesis following exposure of cells to delta-aminolevulinic acid? Gibson, S.L., Havens, J.J., Metz, L., Hilf, R. Photochem. Photobiol. (2001) [Pubmed]
  5. Increase of delta-aminolevulinic acid dehydratase (ALAD) in rat erythrocytes in lead poisoning. Kajimoto, M., Kondo, M., Niwa, M., Suzuki, T., Kimura, H., Sasaki, A., Urata, G. Arch. Toxicol. (1983) [Pubmed]
  6. Influence of protein calorie malnutrition and fasting on the activities of delta-aminolevulinic acid dehydratase and porphobilinogen deaminase in rats. Adjarov, D.G., Naydenova, E.N., Kerimova, M.A., Pentieva, K.D., Ivanova, L.B., Ivanova, A.V. Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie. (1994) [Pubmed]
  7. Isolation of a rat liver delta-aminolevulinate dehydrase (ALAD) cDNA clone: evidence for unequal ALAD gene dosage among inbred mouse strains. Bishop, T.R., Cohen, P.J., Boyer, S.H., Noyes, A.N., Frelin, L.P. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  8. Nucleotide sequence of rat liver delta-aminolevulinic acid dehydratase cDNA. Bishop, T.R., Frelin, L.P., Boyer, S.H. Nucleic Acids Res. (1986) [Pubmed]
  9. Selenium effects on gallium arsenide induced biochemical and immunotoxicological changes in rats. Flora, S.J., Kannan, G.M., Kumar, P. Chem. Biol. Interact. (1999) [Pubmed]
  10. delta-Aminolevulinic acid dehydratase: effects of succinylacetone in rat liver and kidney in an in vivo model of the renal Fanconi syndrome. Wyss, P.A., Carter, B.E., Roth, K.S. Biochem. Med. Metab. Biol. (1992) [Pubmed]
  11. Inhibition of delta aminolevulinic acid dehydratase activity by aluminum. Zaman, K., Zaman, W., Dabrowski, Z., Miszta, H. Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. (1993) [Pubmed]
  12. Effects of lead inhalation exposures alone and in combination with carbon monoxide in nonpregnant and pregnant rats and fetuses. II. Effects on delta-aminolevulinic acid dehydratase activity, hematocrit and body weight. Prigge, E., Greve, J. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe B: Hygiene, präventive Medizin. (1977) [Pubmed]
  13. Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats. Gürer, H., Ozgünes, H., Neal, R., Spitz, D.R., Erçal, N. Toxicology (1998) [Pubmed]
  14. Metabolic effects of histidine-deficient diets fed to growing rats by gastric tube. Clemens, R.A., Kopple, J.D., Swendseid, M.E. J. Nutr. (1984) [Pubmed]
  15. Kinetics of aluminum-induced inhibition of delta-aminolevulinic acid dehydratase in vitro. Schroeder, T.M., Caspers, M.L. Biochem. Pharmacol. (1996) [Pubmed]
  16. Chronic inhalation effects of tetrachloroethylene on hepatic and renal microsomal electron transport components and delta-aminolevulinic acid dehydratase in rats. Soni, M., Nomiyama, H., Nomiyama, K. Toxicol. Lett. (1990) [Pubmed]
  17. Hematological changes in rats chronically exposed to oral aluminum. Farina, M., Rotta, L.N., Soares, F.A., Jardim, F., Jacques, R., Souza, D.O., Rocha, J.B. Toxicology (2005) [Pubmed]
  18. Effect of chronic vanadium administration in drinking water to rats. Zaporowska, H., Wasilewski, W., Słotwińska, M. Biometals (1993) [Pubmed]
  19. Cytochrome P-450 system dependent depression of delta-aminolevulinic acid dehydratase activity by bromobenzene in rats. Koizumi, A., Fujita, H., Sadamoto, T., Ohmachi, T., Watanabe, M., Ikeda, M. Toxicology (1984) [Pubmed]
  20. Influence of dietary zinc on lead toxicity during gestation and lactation in the female rat. Cerklewski, F.L. J. Nutr. (1979) [Pubmed]
  21. Developmental changes in delta-aminolevulinic acid dehydratase (ALAD) activity and blood reticulocyte percent in the developing rat. A brief note. Davis, J.R., Avram, M.J. Mech. Ageing Dev. (1978) [Pubmed]
  22. Rapid loss of delta-aminolevulinic acid dehydratase activity in primary cultures of adult rat hepatocytes: a new model of zinc deficiency. Guzelian, P.S., O'Connor, L., Fernandez, S., Chan, W., Giampietro, P., Desnick, R. Life Sci. (1982) [Pubmed]
  23. Beneficial role of monoesters of meso-2,3-dimercaptosuccinic acid in the mobilization of lead and recovery of tissue oxidative injury in rats. Saxena, G., Pathak, U., Flora, S.J. Toxicology (2005) [Pubmed]
  24. Effect of Centella asiatica on arsenic induced oxidative stress and metal distribution in rats. Gupta, R., Flora, S.J. Journal of applied toxicology : JAT. (2006) [Pubmed]
  25. Effect of chronic aurothioglucose treatment of rats on kidney catalase and cytochromes. Hu, M.L., Dillard, C.J., Tappel, A.L. J. Inorg. Biochem. (1988) [Pubmed]
  26. Reversal of lead-induced oxidative stress by chelating agent, antioxidant, or their combination in the rat. Tandon, S.K., Singh, S., Prasad, S., Srivastava, S., Siddiqui, M.K. Environmental research. (2002) [Pubmed]
  27. The effect of zinc on the toxic action of lead after administration of ethanol to rats. Kulikowska, E., Moniuszko-Jakoniuk, J., Miniuk, K. Polish journal of pharmacology and pharmacy. (1989) [Pubmed]
  28. Metal constitution of metallothionein influences inhibition of delta-aminolaevulinic acid dehydratase (porphobilinogen synthase) by lead. Goering, P.L., Fowler, B.A. Biochem. J. (1987) [Pubmed]
  29. Meso 2,3-dimercaptosuccinic acid (DMSA) and monoisoamyl DMSA effect on gallium arsenide induced pathological liver injury in rats. Flora, S.J., Dubey, R., Kannan, G.M., Chauhan, R.S., Pant, B.P., Jaiswal, D.K. Toxicol. Lett. (2002) [Pubmed]
  30. Maintenance of zinc-dependent hepatic functions in rat hepatocytes cultured in medium without added zinc. Schroeder, J.J., Cousins, R.J. J. Nutr. (1991) [Pubmed]
  31. Effect of small doses of ethylene glycol monomethyl ether on the acetylcholinesterase and delta-aminolevulinic acid dehydratase activity in erythrocytes, blood and bone marrow of rats. Lazewska, M., Tabarowski, Z., Dabrowski, Z. Toxicology and industrial health. (1993) [Pubmed]
  32. Preventive effects of sodium molybdate in lead intoxication in rats. Flora, S.J., Jeevaratnam, K., Kumar, D. Ecotoxicol. Environ. Saf. (1993) [Pubmed]
  33. Du-zhong (Eucommia ulmoides Oliv.) cortex water extract alters heme biosynthesis and erythrocyte antioxidant defense system in lead-administered rats. Lee, M.K., Cho, S.Y., Kim, D.J., Jang, J.Y., Shin, K.H., Park, S.A., Park, E.M., Lee, J.S., Choi, M.S., Lee, J.S., Kim, M.J. Journal of medicinal food. (2005) [Pubmed]
  34. Therapeutic potential of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats. Flora, S.J., Mehta, A., Rao, P.V., Kannan, G.M., Bhaskar, A.S., Dube, S.N., Pant, B.P. Toxicology (2004) [Pubmed]
  35. Evidence of increased synthesis of delta-aminolevulinic acid dehydratase in experimental lead-poisoned rats. Fujita, H., Orii, Y., Sano, S. Biochim. Biophys. Acta (1981) [Pubmed]
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