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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Identification of plexin family molecules in mice.

By screening of E17.5 mouse brain cDNA libraries, we isolated two cDNAs encoding new plexin-like proteins. Sequencing revealed that these two proteins were type 1 membrane proteins which showed over 60% identity at the amino acid level to mouse plexin 1. Moreover, putative extracellular segments of these two proteins had three repeats of a cysteine-rich domain which is a common motif for plexin proteins. Thus, we named these two proteins mouse plexin 2 and mouse plexin 3. We obtained mouse plexin 3 cDNA clones in which a part of protein-coding region was deleted. Also, Northern blot analysis showed molecular heterogeneity in mouse plexin 2 mRNAs. These findings indicate that in the mouse, plexins comprise a molecular family (the plexin family).[1]


  1. Identification of plexin family molecules in mice. Kameyama, T., Murakami, Y., Suto, F., Kawakami, A., Takagi, S., Hirata, T., Fujisawa, H. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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