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Gene Review

Plxna1  -  plexin A1

Mus musculus

Synonyms: 2600013D04Rik, Kiaa4053, NOV, Plex 1, PlexA1, ...
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High impact information on Plxna1


Biological context of Plxna1


Anatomical context of Plxna1


Associations of Plxna1 with chemical compounds

  • Moreover, putative extracellular segments of these two proteins had three repeats of a cysteine-rich domain which is a common motif for plexin proteins [6].
  • Furthermore, we show that plexin-A1 associates with the triggering receptor expressed on myeloid cells-2 (Trem-2), linking semaphorin-signalling to the immuno-receptor tyrosine-based activation motif (ITAM)-bearing adaptor protein, DAP12 [8].
  • Interestingly, integrin-based focal adhesive structures are disassembled within minutes upon plexin activation; this is followed by actin depolymerization and, eventually, by cellular collapse [11].

Physical interactions of Plxna1


Regulatory relationships of Plxna1

  • Here, we show that plexin-A3 is the most ubiquitously expressed plexin family member within regions of the developing mammalian nervous system known to contain semaphorin-responsive neurons [12].

Other interactions of Plxna1

  • Identification and characterization of a novel mouse plexin, plexin-A4 [13].
  • It has been proposed that four members of the plexin A subfamily (plexin-As; plexin-A1, -A2, -A3, and -A4) and two neuropilins (neuropilin-1 and neuropilin-2) form complexes and serve as receptors for class 3 secreted semaphorins (Semas), potent neural chemorepellents [14].
  • Thus, we named these two proteins mouse plexin 2 and mouse plexin 3 [6].
  • A physical and functional association between Met and Plexin B1, the prototype of class B Plexin subfamily, has been previously demonstrated [15].
  • We found the semaphorin receptor plexin-A1 was expressed in DCs, but not in other immune cells, and was strongly induced by CIITA [2].

Analytical, diagnostic and therapeutic context of Plxna1

  • Northern blot analysis indicated that mouse plexin 1 was predominantly expressed in the brain [16].
  • MATERIALS AND METHODS: ATDC5 cells and primary chondrocytes were either treated with NOV recombinant protein or transfected with a NOV-specific siRNA to determine, using quantitative RT-PCR, the effect of NOV on the expression of several molecules involved in chondrocyte differentiation [17].
  • Hybridoma antibodies which reacted against the nonoccluded form (NOV) of AcNPV in an ELISA test expressed different specificities for the occluded form of the virus (OV), a mutant strain of AcNPV, and CfNPV [18].
  • The polypeptide specificity of 19 of 28 hybridoma antibodies which reacted with OV and NOV of AcNPV was assigned using Western blot analysis [18].


  1. Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Takahashi, T., Fournier, A., Nakamura, F., Wang, L.H., Murakami, Y., Kalb, R.G., Fujisawa, H., Strittmatter, S.M. Cell (1999) [Pubmed]
  2. CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions. Wong, A.W., Brickey, W.J., Taxman, D.J., van Deventer, H.W., Reed, W., Gao, J.X., Zheng, P., Liu, Y., Li, P., Blum, J.S., McKinnon, K.P., Ting, J.P. Nat. Immunol. (2003) [Pubmed]
  3. FARP2 triggers signals for Sema3A-mediated axonal repulsion. Toyofuku, T., Yoshida, J., Sugimoto, T., Zhang, H., Kumanogoh, A., Hori, M., Kikutani, H. Nat. Neurosci. (2005) [Pubmed]
  4. Chromosome assignment of four plexin A genes (Plxna1, Plxna2, Plxna3, Plxna4) in mouse, rat, Syrian hamster and Chinese hamster. Kuroiwa, A., Suto, F., Fujisawa, H., Matsuda, Y. Cytogenet. Cell Genet. (2001) [Pubmed]
  5. Diverse gene expression and function of semaphorins in developing lung: positive and negative regulatory roles of semaphorins in lung branching morphogenesis. Kagoshima, M., Ito, T. Genes Cells (2001) [Pubmed]
  6. Identification of plexin family molecules in mice. Kameyama, T., Murakami, Y., Suto, F., Kawakami, A., Takagi, S., Hirata, T., Fujisawa, H. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  7. The expression of plexins during mouse embryogenesis. Perälä, N.M., Immonen, T., Sariola, H. Gene Expr. Patterns (2005) [Pubmed]
  8. Plexin-A1 and its interaction with DAP12 in immune responses and bone homeostasis. Takegahara, N., Takamatsu, H., Toyofuku, T., Tsujimura, T., Okuno, T., Yukawa, K., Mizui, M., Yamamoto, M., Prasad, D.V., Suzuki, K., Ishii, M., Terai, K., Moriya, M., Nakatsuji, Y., Sakoda, S., Sato, S., Akira, S., Takeda, K., Inui, M., Takai, T., Ikawa, M., Okabe, M., Kumanogoh, A., Kikutani, H. Nat. Cell Biol. (2006) [Pubmed]
  9. Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A. Rohm, B., Ottemeyer, A., Lohrum, M., Püschel, A.W. Mech. Dev. (2000) [Pubmed]
  10. Stereotyped axon pruning via plexin signaling is associated with synaptic complex elimination in the hippocampus. Liu, X.B., Low, L.K., Jones, E.G., Cheng, H.J. J. Neurosci. (2005) [Pubmed]
  11. Plexin signaling hampers integrin-based adhesion, leading to Rho-kinase independent cell rounding, and inhibiting lamellipodia extension and cell motility. Barberis, D., Artigiani, S., Casazza, A., Corso, S., Giordano, S., Love, C.A., Jones, E.Y., Comoglio, P.M., Tamagnone, L. FASEB J. (2004) [Pubmed]
  12. Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. Cheng, H.J., Bagri, A., Yaron, A., Stein, E., Pleasure, S.J., Tessier-Lavigne, M. Neuron (2001) [Pubmed]
  13. Identification and characterization of a novel mouse plexin, plexin-A4. Suto, F., Murakami, Y., Nakamura, F., Goshima, Y., Fujisawa, H. Mech. Dev. (2003) [Pubmed]
  14. Plexin-a4 mediates axon-repulsive activities of both secreted and transmembrane semaphorins and plays roles in nerve fiber guidance. Suto, F., Ito, K., Uemura, M., Shimizu, M., Shinkawa, Y., Sanbo, M., Shinoda, T., Tsuboi, M., Takashima, S., Yagi, T., Fujisawa, H. J. Neurosci. (2005) [Pubmed]
  15. Interplay between scatter factor receptors and B plexins controls invasive growth. Conrotto, P., Corso, S., Gamberini, S., Comoglio, P.M., Giordano, S. Oncogene (2004) [Pubmed]
  16. Identification of a neuronal cell surface molecule, plexin, in mice. Kameyama, T., Murakami, Y., Suto, F., Kawakami, A., Takagi, S., Hirata, T., Fujisawa, H. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  17. New target genes for NOV/CCN3 in chondrocytes: TGF-beta2 and type X collagen. Lafont, J., Jacques, C., Le Dreau, G., Calhabeu, F., Thibout, H., Dubois, C., Berenbaum, F., Laurent, M., Martinerie, C. J. Bone Miner. Res. (2005) [Pubmed]
  18. Monoclonal antibodies to baculovirus structural proteins: determination of specificities by Western blot analysis. Hohmann, A.W., Faulkner, P. Virology (1983) [Pubmed]
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