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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Renal and spermatozoal toxicity of alpha-bromohydrin, 3-bromolactate and 3-bromopyruvate.

(R,S)- and (R)-3-Bromopropan-1,2-diol (alpha-bromohydrin) produced diuresis and glucosuria when administered to male rats but had no effect on the metabolic activity of rat kidney tubules in vitro. The oxidation products (R,S)-3-bromolactate and 3-bromopyruvate produced brief phases of diuresis but not glucosuria, and severely inhibited the metabolic activity of rat kidney tubules in vitro. alpha-Bromohydrin had no effect on the metabolic activity of boar spermatozoa whereas the oxidation products severely affected mitochondrial metabolism. 3-Bromopyruvate also inhibited boar spermatozoal glyceraldehyde 3-phosphate dehydrogenase.[1]

References

  1. Renal and spermatozoal toxicity of alpha-bromohydrin, 3-bromolactate and 3-bromopyruvate. Jones, A.R., Porter, K.E., Dobbie, M.S. Journal of applied toxicology : JAT. (1996) [Pubmed]
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