The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Kidney Tubules

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Kidney Tubules


High impact information on Kidney Tubules


Chemical compound and disease context of Kidney Tubules


Biological context of Kidney Tubules


Anatomical context of Kidney Tubules


Associations of Kidney Tubules with chemical compounds

  • Initial experiments indicated an active hexose transport capacity, a property thought to be restricted in mammals to intestinal villi and kidney tubules [Baly, D. L. & Horuk, R. (1988) Biochim. Biophys. Acta 947, 571-590] [26].
  • Distribution of calcitonin-sensitive adenylate cyclase activity along the rabbit kidney tubule [27].
  • Based on the chemistry of platinum-sulfur interactions and the observed time-dependence of the rescue treatment, it is suggested that dithiocarbamate exerts its effects via competitive chelation and removal of platinum coordinated to protein-bound sulfhydryl groups of the kidney tubule cells [28].
  • Moreover, markedly broadened BMs were found in the atrioventricular valves of the heart and in the kidney tubules, whereas the glomerular mesangial matrix of the kidneys was expanded in the mutant mice and serum creatinine levels were elevated, indicating alterations in kidney filtration capacity [29].
  • The anaplerotic substrate alanine stimulates acetate incorporation into glutamate and glutamine in rabbit kidney tubules. A (13)C NMR study [30].

Gene context of Kidney Tubules


Analytical, diagnostic and therapeutic context of Kidney Tubules


  1. Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure. Megyesi, J., Safirstein, R.L., Price, P.M. J. Clin. Invest. (1998) [Pubmed]
  2. Renal mechanism of trimethoprim-induced hyperkalemia. Velázquez, H., Perazella, M.A., Wright, F.S., Ellison, D.H. Ann. Intern. Med. (1993) [Pubmed]
  3. Identification of a 400-kd protein in the brush borders of human kidney tubules that is similar to gp330, the nephritogenic antigen of rat Heymann nephritis. Kerjaschki, D., Horvat, R., Binder, S., Susani, M., Dekan, G., Ojha, P.P., Hillemanns, P., Ulrich, W., Donini, U. Am. J. Pathol. (1987) [Pubmed]
  4. Induction and targeting of the glutamine transporter SN1 to the basolateral membranes of cortical kidney tubule cells during chronic metabolic acidosis suggest a role in pH regulation. Solbu, T.T., Boulland, J.L., Zahid, W., Lyamouri Bredahl, M.K., Amiry-Moghaddam, M., Storm-Mathisen, J., Roberg, B.A., Chaudhry, F.A. J. Am. Soc. Nephrol. (2005) [Pubmed]
  5. In vitro cell cycle arrest, in vivo action on solid metastasizing tumors, and host toxicity of the antimetastatic drug NAMI-A and cisplatin. Bergamo, A., Gagliardi, R., Scarcia, V., Furlani, A., Alessio, E., Mestroni, G., Sava, G. J. Pharmacol. Exp. Ther. (1999) [Pubmed]
  6. Mutations in a novel gene, NPHP3, cause adolescent nephronophthisis, tapeto-retinal degeneration and hepatic fibrosis. Olbrich, H., Fliegauf, M., Hoefele, J., Kispert, A., Otto, E., Volz, A., Wolf, M.T., Sasmaz, G., Trauer, U., Reinhardt, R., Sudbrak, R., Antignac, C., Gretz, N., Walz, G., Schermer, B., Benzing, T., Hildebrandt, F., Omran, H. Nat. Genet. (2003) [Pubmed]
  7. Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene family. Schlingmann, K.P., Weber, S., Peters, M., Niemann Nejsum, L., Vitzthum, H., Klingel, K., Kratz, M., Haddad, E., Ristoff, E., Dinour, D., Syrrou, M., Nielsen, S., Sassen, M., Waldegger, S., Seyberth, H.W., Konrad, M. Nat. Genet. (2002) [Pubmed]
  8. Regulation and inhibition of arachidonic acid omega-hydroxylases and 20-HETE formation. Kroetz, D.L., Xu, F. Annu. Rev. Pharmacol. Toxicol. (2005) [Pubmed]
  9. Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin and the catenins. Huan, Y., van Adelsberg, J. J. Clin. Invest. (1999) [Pubmed]
  10. Regulation of the costimulator B7, not class II major histocompatibility complex, restricts the ability of murine kidney tubule cells to stimulate CD4+ T cells. Hagerty, D.T., Evavold, B.D., Allen, P.M. J. Clin. Invest. (1994) [Pubmed]
  11. Exocytosis of storage material in a lysosomal disorder. Klein, D., Büssow, H., Fewou, S.N., Gieselmann, V. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  12. Toxicity of chloroacetaldehyde is similar in adult and pediatric kidney tubules. Dubourg, L., Tanière, P., Cochat, P., Baverel, G., Michoudet, C. Pediatr. Nephrol. (2002) [Pubmed]
  13. A possible genetic pattern of taurine urinary excretion in Friedreich's Ataxia. Barbeau, A., Patenaude, F., Nadon, G., Charbonneau, M., Cloutier, T. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques. (1982) [Pubmed]
  14. Gallium nitrate (NSC-15200) induced toxicity in the rat: a pharmacologic, histopathologic and microanalytical investigation. Newman, R.A., Brody, A.R., Krakoff, I.H. Cancer (1979) [Pubmed]
  15. Effect of different preservation solutions and substrates on metabolic viability of kidney tubules. Fischer, W., Manz, F., Schärer, K. Current problems in clinical biochemistry. (1977) [Pubmed]
  16. Polyvalent cation receptor proteins (CaRs) are salinity sensors in fish. Nearing, J., Betka, M., Quinn, S., Hentschel, H., Elger, M., Baum, M., Bai, M., Chattopadyhay, N., Brown, E.M., Hebert, S.C., Harris, H.W. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  17. [Leu]enkephalin stimulates carbohydrate metabolism in isolated hepatocytes and kidney tubule fragments by interaction with angiotensin II receptors. Hothi, S.K., Randall, D.P., Titheradge, M.A. Biochem. J. (1989) [Pubmed]
  18. Effects of 4-dimethylaminophenol in rat kidneys, isolated rat kidney tubules and hepatocytes. Szinicz, L.L., Weger, N. Xenobiotica (1980) [Pubmed]
  19. Renal and spermatozoal toxicity of alpha-bromohydrin, 3-bromolactate and 3-bromopyruvate. Jones, A.R., Porter, K.E., Dobbie, M.S. Journal of applied toxicology : JAT. (1996) [Pubmed]
  20. Developmental estrogenic exposure in zebrafish (Danio rerio): II. Histological evaluation of gametogenesis and organ toxicity. Weber, L.P., Hill, R.L., Janz, D.M. Aquat. Toxicol. (2003) [Pubmed]
  21. Recognition of the laminin E8 cell-binding site by an integrin possessing the alpha 6 subunit is essential for epithelial polarization in developing kidney tubules. Sorokin, L., Sonnenberg, A., Aumailley, M., Timpl, R., Ekblom, P. J. Cell Biol. (1990) [Pubmed]
  22. Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. Nomura, S., Wills, A.J., Edwards, D.R., Heath, J.K., Hogan, B.L. J. Cell Biol. (1988) [Pubmed]
  23. Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study. Verbavatz, J.M., Brown, D., Sabolić, I., Valenti, G., Ausiello, D.A., Van Hoek, A.N., Ma, T., Verkman, A.S. J. Cell Biol. (1993) [Pubmed]
  24. Platelet glycoprotein IIb/IIIa complex in cultured cells. Localization in focal adhesion sites in spreading HEL cells. Ylänne, J., Hormia, M., Järvinen, M., Vartio, T., Virtanen, I. Blood (1988) [Pubmed]
  25. Role of beta-dystrobrevin in nonmuscle dystrophin-associated protein complex-like complexes in kidney and liver. Loh, N.Y., Nebenius-Oosthuizen, D., Blake, D.J., Smith, A.J., Davies, K.E. Mol. Cell. Biol. (2001) [Pubmed]
  26. An unusual active hexose transport system in human and mouse preimplantation embryos. Chi, M.M., Manchester, J.K., Basuray, R., Mahendra, S., Strickler, R.C., McDougal, D.B., Lowry, O.H. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  27. Distribution of calcitonin-sensitive adenylate cyclase activity along the rabbit kidney tubule. Chabardès, D., Imbert-Teboul, M., Montégut, M., Clique, A., Morel, F. Proc. Natl. Acad. Sci. U.S.A. (1976) [Pubmed]
  28. Inhibition of cis-platinum nephrotoxicity by diethyldithiocarbamate rescue in a rat model. Borch, R.F., Pleasants, M.E. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  29. Structurally altered basement membranes and hydrocephalus in a type XVIII collagen deficient mouse line. Utriainen, A., Sormunen, R., Kettunen, M., Carvalhaes, L.S., Sajanti, E., Eklund, L., Kauppinen, R., Kitten, G.T., Pihlajaniemi, T. Hum. Mol. Genet. (2004) [Pubmed]
  30. The anaplerotic substrate alanine stimulates acetate incorporation into glutamate and glutamine in rabbit kidney tubules. A (13)C NMR study. Conjard, A., Dugelay, S., Chauvin, M.F., Durozard, D., Baverel, G., Martin, G. J. Biol. Chem. (2002) [Pubmed]
  31. Fibrillin-1 and fibulin-2 interact and are colocalized in some tissues. Reinhardt, D.P., Sasaki, T., Dzamba, B.J., Keene, D.R., Chu, M.L., Göhring, W., Timpl, R., Sakai, L.Y. J. Biol. Chem. (1996) [Pubmed]
  32. Matrix metalloproteinase-2 in a murine model of infantile-type polycystic kidney disease. Rankin, C.A., Itoh, Y., Tian, C., Ziemer, D.M., Calvet, J.P., Gattone, V.H. J. Am. Soc. Nephrol. (1999) [Pubmed]
  33. Transient expression of Dp140, a product of the Duchenne muscular dystrophy locus, during kidney tubulogenesis. Durbeej, M., Jung, D., Hjalt, T., Campbell, K.P., Ekblom, P. Dev. Biol. (1997) [Pubmed]
  34. Matrix metalloproteinases and TIMPS in cultured C57BL/6J-cpk kidney tubules. Rankin, C.A., Suzuki, K., Itoh, Y., Ziemer, D.M., Grantham, J.J., Calvet, J.P., Nagase, H. Kidney Int. (1996) [Pubmed]
  35. Distribution and developmentally regulated expression of murine polycystin. Geng, L., Segal, Y., Pavlova, A., Barros, E.J., Löhning, C., Lu, W., Nigam, S.K., Frischauf, A.M., Reeders, S.T., Zhou, J. Am. J. Physiol. (1997) [Pubmed]
  36. Polypeptides of the Golgi apparatus of neurons from rat brain. Gonatas, J.O., Gonatas, N.K., Stieber, A., Louvard, D. J. Neurochem. (1987) [Pubmed]
  37. Molecular cloning and expression pattern of rpr-1, a resiniferatoxin-binding, phosphotriesterase-related protein, expressed in rat kidney tubules. Davies, J.A., Buchman, V.L., Krylova, O., Ninkina, N.N. FEBS Lett. (1997) [Pubmed]
WikiGenes - Universities