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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Physical activity and dietary constituents as predictors of forearm cortical and trabecular bone gain in healthy children and adolescents: a prospective study.

We have prospectively studied forearm trabecular and cortical bone mineral density gain (delta BMD) in relation to nutrient intake, weight-bearing physical activity (WPA) and daylight exposure (DE) in 470 healthy boys and girls aged 8.2-16.5 years at the baseline. BMD was assessed using single photon absorptiometry (SPA). Cortical delta BMD peaked at the age of 14.0 +/- 0.3 and 16.0 +/- 0.3 (SD) years in girls and boys, respectively. Girls had achieved adult premenopausal values of trabecular BMD by the age of 15 years and cortical BMD values by the age of 16.5 years. WPA, BMD, body height, height gain, weight, weight gain, dietary polyunsaturated fat and sodium were correlated with delta BMD. WPA, predicting cortical as well as trabecular delta BMD, had the greatest effect on trabecular delta BMD in the presence of a high calcium intake in children below 11 years of age. In conclusion, our results indicate that physical activity and calcium intake should be encouraged at a prepubertal age in order to increase bone density.[1]


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