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Disease relevance of Weight-Bearing


High impact information on Weight-Bearing

  • Weight bearing as a treatment for damaged hips in juvenile rheumatoid arthritis [6].
  • This ability has been postulated to be under the control of polysaccharide hydrolases or transferases that weaken or rearrange the loadbearing polymeric networks in the wall [7].
  • The chondroitin sulfate proteoglycan aggrecan forms link protein-stabilized complexes with hyaluronan (HA), via its N-terminal G1-domain, that provide cartilage with its load bearing properties [8].
  • We show that dephosphorylation of NFATc1, MEF2A, and MEF2D transcription factors by calcineurin in all muscle types is dependent on nerve activity and positively correlated with muscle usage under normal weightbearing conditions [9].
  • The skeletal muscle sarco(endo)plasmic reticulum calcium ATPase (SERCA1) gene is transactivated as early as 2 days after the removal of weight-bearing (Peters, D. G., Mitchell-Felton, H., and Kandarian, S. C. (1999) Am. J. Physiol. 276, C1218-C1225), but the transcriptional mechanisms are elusive [10].

Chemical compound and disease context of Weight-Bearing


Biological context of Weight-Bearing

  • RESULTS: Of the 224 patients, 62% had at least 1 documented intervention aimed at osteoporosis prevention (counseling about calcium or vitamin D or weight-bearing exercise; prescription for estrogen, calcitonin, or bisphosphonate; or a bone mineral density study) [16].
  • PTH can prevent the decrease in cancellous bone volume and reduce the decrement in cortical bone formation induced by loss of weight bearing [17].
  • Programed administration of PTH had no effect on either radial or longitudinal bone growth in weight-bearing and hindlimb-unloaded OVX rats [18].
  • As in primates, the TMJ was found to be load-bearing during mastication, with compressive strain oriented approximately perpendicular to the occlusal plane [19].
  • Using a rule-of-mixtures model for the stress response and first order kinetics for the production and removal of the three primary load-bearing constituents within the wall, we illustrate capabilities of the model by comparing responses given complete versus negligible turnover of elastin [20].

Anatomical context of Weight-Bearing


Associations of Weight-Bearing with chemical compounds

  • In isolated unloaded soleus, insulin (0.1 milliunit/ml) increased the oxidation of D-[U-14C]glucose, release of lactate and pyruvate, incorporation of D-[U-14C]glucose into glycogen, and the concentration of glucose 6-phosphate more (p less than 0.05) than in the weight-bearing soleus [25].
  • These results indicated that the beneficial effects of treadmill running exercise under a standard calcium diet were recognized only in the weight-bearing bones of the mature osteopenic rats resulting from estrogen deficiency and inadequate calcium intake only when an optimal level of exercise was applied [26].
  • The major weight-bearing components of the hip (anterior and posterior acetabular columns, acetabular dome, and superior pole of the femur), which may be poorly defined on CT scans due to partial volume effects on the transaxial images, were best seen on the sagittal and coronal reconstructions [27].
  • However, administration of 30 mg/kg celecoxib twice daily for 10 days resulted in a significant restoration of hind limb weight bearing [23].
  • Effects of post-administered HU210 and JWH-133 on ipsilateral hindpaw weight bearing and paw volume were comparable to the effect of systemic post-administration of morphine and rofecoxib (3 mg/kg for both) [3].

Gene context of Weight-Bearing

  • The level of Trim32 expression was elevated significantly in muscle undergoing remodeling due to changes in weight bearing [28].
  • Given what is known about the distribution of the fibrillins in normal tissues and the abnormalities that result when mutations occur, a basic hypothesis has emerged: fibrillin-1 is primarily responsible for load bearing and providing structural integrity, whereas fibrillin-2 may be a director of elastogenesis [29].
  • The objective of this study was to examine the metabolism of aggrecan, biglycan, and decorin in articular cartilage from different weight-bearing areas of normal ovine stifle joints and in joints 6 months after menisectomy, a procedure that has been shown to induce early osteorthritic changes [30].
  • PURPOSE: Elastin and collagen (types I and III) are the primary load-bearing elements in aortic tissue [31].
  • 4. Pretreatment systemically with the NK1 receptor antagonist (30 mg kg-1) had no effect on the heat hyperalgesia or pain-related behaviour ratings where 0 is none and 5 is non weight bearing and complete avoidance of limb contact [32].

Analytical, diagnostic and therapeutic context of Weight-Bearing


  1. Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity. Offley, S.C., Guo, T.Z., Wei, T., Clark, J.D., Vogel, H., Lindsey, D.P., Jacobs, C.R., Yao, W., Lane, N.E., Kingery, W.S. J. Bone Miner. Res. (2005) [Pubmed]
  2. Missed opportunities for prevention of osteoporotic fracture. Gallagher, T.C., Geling, O., Comite, F. Arch. Intern. Med. (2002) [Pubmed]
  3. Activation of CB1 and CB2 receptors attenuates the induction and maintenance of inflammatory pain in the rat. Elmes, S.J., Winyard, L.A., Medhurst, S.J., Clayton, N.M., Wilson, A.W., Kendall, D.A., Chapman, V. Pain (2005) [Pubmed]
  4. The impact of lifestyle factors on stress fractures in female Army recruits. Lappe, J.M., Stegman, M.R., Recker, R.R. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. (2001) [Pubmed]
  5. Ketamine improves the management of exaggerated postoperative pain observed in perioperative fentanyl-treated rats. Richebé, P., Rivat, C., Laulin, J.P., Maurette, P., Simonnet, G. Anesthesiology (2005) [Pubmed]
  6. Weight bearing as a treatment for damaged hips in juvenile rheumatoid arthritis. Jacobs, J.C., Dick, H.M., Downey, J.A., Edgar, A., Sternstein, R., Berdon, W.E. N. Engl. J. Med. (1981) [Pubmed]
  7. Disruption of hydrogen bonding between plant cell wall polymers by proteins that induce wall extension. McQueen-Mason, S., Cosgrove, D.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan oligosaccharides. Seyfried, N.T., McVey, G.F., Almond, A., Mahoney, D.J., Dudhia, J., Day, A.J. J. Biol. Chem. (2005) [Pubmed]
  9. Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. Dunn, S.E., Simard, A.R., Bassel-Duby, R., Williams, R.S., Michel, R.N. J. Biol. Chem. (2001) [Pubmed]
  10. Identification of weight-bearing-responsive elements in the skeletal muscle sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) gene. Mitchell-Felton, H., Hunter, R.B., Stevenson, E.J., Kandarian, S.C. J. Biol. Chem. (2000) [Pubmed]
  11. Physical activity and the common cold in men administered vitamin E and beta-carotene. Hemilä, H., Virtamo, J., Albanes, D., Kaprio, J. Medicine and science in sports and exercise. (2003) [Pubmed]
  12. Coupling between dietary changes, reduced body weight, muscle fibre size and improved glucose tolerance in middle-aged men with impaired glucose tolerance. Lindgärde, F., Eriksson, K.F., Lithell, H., Saltin, B. Acta medica Scandinavica. (1982) [Pubmed]
  13. The effects of hypothyroidism on nerve growth factor and norepinephrine concentrations in weight-bearing and non-weight-bearing bones of rats. Yao, M., Dooley, P.C., Schuijers, J.A., Grills, B.L. Journal of musculoskeletal & neuronal interactions. (2004) [Pubmed]
  14. Mefenamic acid and diclofenac sodium in osteoarthritis of the weight bearing joints: a double blind comparison. Aylward, M., Maddock, J., Lewis, P.A., Dewland, P.M. The British journal of clinical practice. (1985) [Pubmed]
  15. Pharmacotherapy of osteoarthritis with particular reference to night pain (double blind trial of pirprofen and piroxicam). Pavelka, K., Trnavský, K. Zeitschrift für Rheumatologie. (1986) [Pubmed]
  16. Prevention of glucocorticoid-induced osteoporosis: experience in a managed care setting. Yood, R.A., Harrold, L.R., Fish, L., Cernieux, J., Emani, S., Conboy, E., Gurwitz, J.H. Arch. Intern. Med. (2001) [Pubmed]
  17. Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading. Halloran, B.P., Bikle, D.D., Harris, J., Tanner, S., Curren, T., Morey-Holton, E. J. Bone Miner. Res. (1997) [Pubmed]
  18. Programmed administration of parathyroid hormone increases bone formation and reduces bone loss in hindlimb-unloaded ovariectomized rats. Turner, R.T., Evans, G.L., Cavolina, J.M., Halloran, B., Morey-Holton, E. Endocrinology (1998) [Pubmed]
  19. Reaction strains on the condylar neck during mastication and maximum muscle stimulation in different condylar positions: an experimental study in the miniature pig. Marks, L., Teng, S., Artun, J., Herring, S. J. Dent. Res. (1997) [Pubmed]
  20. A 2-D model of flow-induced alterations in the geometry, structure, and properties of carotid arteries. Gleason, R.L., Taber, L.A., Humphrey, J.D. Journal of biomechanical engineering. (2004) [Pubmed]
  21. Elevated substance P and accelerated cartilage degradation in rabbit knees injected with interleukin-1 and tumor necrosis factor. O'Byrne, E.M., Blancuzzi, V., Wilson, D.E., Wong, M., Jeng, A.Y. Arthritis Rheum. (1990) [Pubmed]
  22. Sympathetic nervous system does not mediate the load-induced cortical new bone formation. de Souza, R.L., Pitsillides, A.A., Lanyon, L.E., Skerry, T.M., Chenu, C. J. Bone Miner. Res. (2005) [Pubmed]
  23. Development and pharmacological characterization of a rat model of osteoarthritis pain. Pomonis, J.D., Boulet, J.M., Gottshall, S.L., Phillips, S., Sellers, R., Bunton, T., Walker, K. Pain (2005) [Pubmed]
  24. Progressive arthropathy in mice with a targeted disruption of the Mop3/Bmal-1 locus. Bunger, M.K., Walisser, J.A., Sullivan, R., Manley, P.A., Moran, S.M., Kalscheur, V.L., Colman, R.J., Bradfield, C.A. Genesis (2005) [Pubmed]
  25. Increased response to insulin of glucose metabolism in the 6-day unloaded rat soleus muscle. Henriksen, E.J., Tischler, M.E., Johnson, D.G. J. Biol. Chem. (1986) [Pubmed]
  26. Effects of exercise on bone mineral density in mature osteopenic rats. Iwamoto, J., Takeda, T., Ichimura, S. J. Bone Miner. Res. (1998) [Pubmed]
  27. Femoral head avascular necrosis: CT assessment with multiplanar reconstruction. Magid, D., Fishman, E.K., Scott, W.W., Brooker, A.F., Arnold, W.P., Lennox, D.W., Siegelman, S.S. Radiology. (1985) [Pubmed]
  28. Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin. Kudryashova, E., Kudryashov, D., Kramerova, I., Spencer, M.J. J. Mol. Biol. (2005) [Pubmed]
  29. Partial cloning and sequencing of chick fibrillin-1 cDNA. Zhou, G., Price, C.E., Rosenquist, T.H., Gadson, P.F., Godfrey, M. In Vitro Cell. Dev. Biol. Anim. (2000) [Pubmed]
  30. Topographic variation in biglycan and decorin synthesis by articular cartilage in the early stages of osteoarthritis: an experimental study in sheep. Little, C.B., Ghosh, P., Bellenger, C.R. J. Orthop. Res. (1996) [Pubmed]
  31. The role of type I collagen in aortic wall strength with a homotrimeric. Vouyouka, A.G., Pfeiffer, B.J., Liem, T.K., Taylor, T.A., Mudaliar, J., Phillips, C.L. J. Vasc. Surg. (2001) [Pubmed]
  32. Differential roles of neurokinin 1 and neurokinin 2 receptors in the development and maintenance of heat hyperalgesia induced by acute inflammation. Sluka, K.A., Milton, M.A., Willis, W.D., Westlund, K.N. Br. J. Pharmacol. (1997) [Pubmed]
  33. Scaffold design and in vitro study of osteochondral coculture in a three-dimensional porous polycaprolactone scaffold fabricated by fused deposition modeling. Cao, T., Ho, K.H., Teoh, S.H. Tissue engineering. (2003) [Pubmed]
  34. Glass ceramic augmentation of the acetabulum. Total hip arthroplasties in 24 dogs. Matsuda, Y., Yamamuro, T., Okumura, H., Ido, K., Nakamura, T. Acta orthopaedica Scandinavica. (1993) [Pubmed]
  35. Plantar pressure reduction in an incremental weight-bearing system. Flynn, T.W., Canavan, P.K., Cavanagh, P.R., Chiang, J.H. Physical therapy. (1997) [Pubmed]
  36. Percutaneous electrical stimulation for clinical tibial fracture repair. Romano, R.L., Burgess, E.M., Rubenstein, C.P. Clin. Orthop. Relat. Res. (1976) [Pubmed]
  37. Disseminated fat necrosis: a rehabilitation challenge. Schwartz, G.S., Herbison, G.J. Archives of physical medicine and rehabilitation. (1989) [Pubmed]
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