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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Early diagnosis of Hepatitis B by Dane particle associated DNA polymerase assay.

We have studied prospectively 178 subjects exposed to hepatitis B and 120 haemodialysed patients for the presence of HGs antigen, e antigen and DNA polymerase as well as for anti-HBs and anti-HBc antibodies. The results suggest that the DNA polymerase assay enables us to diagnose hepatitis B earlier than the radioimmunoassay for HGs and that DNA polymerase might be present in the blood in the absence of HBs in cases of confirmed hepatitis B. A posititive correlation between e antigen and DNA polymerase was observed in 83% of the patients on haemodialysis who developed hepatitis B but only in 9% of normal patients developing the same disease.[1]

References

  1. Early diagnosis of Hepatitis B by Dane particle associated DNA polymerase assay. Cappel, R., De Cuyper, F., Van Beers, D., Toppet, M., Cadranel, S. J. Gen. Virol. (1977) [Pubmed]
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