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Peng, C.F. et al.

The protective effects of ischemic and calcitonin gene-related peptide- induced preconditioning on myocardial injury by endothelin-1 in the isolated perfused rat heart.

This study was to investigate the effects of ischemic preconditioning on endothelin-1- induced myocardial injury and the role of calcitonin gene-related peptide (CGRP) played in such effects. The rat hearts were perfused in a Langendorff mode. Heart rates (HR), coronary flow (CF), left ventricular pressure (LVP) and its first derivative (LV dp/dtmax) were recorded and creatinine phosphate kinase (CPK) from coronary effluent was measured. There were no changes in HR, CF, LVP, or LV dp/dtmax throughout the experiment in the control hearts. Endothelin-1 (100 pmol) significantly decreased HR and CF, impaired the cardiac function, and increased the CPK release. However, the HR, CF, LVP and LV dp/dtmax were significantly improved, while the CPK release was decreased in the preconditioned hearts. CGRP8-37, a selective CGRP receptor antagonist, abolished the cardioprotection of ischemic preconditioning, such as the cardiac function and the CPK release. A similar cardioprotection was observed in the hearts pretreated with CGRP. However, the CGRP-induced preconditioning-like protection was abolished in the presence of CGRP8-17 or 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine, an inhibitor of protein kinase C. The present study suggests that the cardioprotective effect of ischemic preconditioning on endothelin-1- induced myocardial injury is mediated by CGRP, and that the cardioprotection of CGRP-induced preconditioning is related to the activation of protein kinase C.[1]

References

The protective effects of ischemic and calcitonin gene-related peptide-induced preconditioning on myocardial injury by endothelin-1 in the isolated perfused rat heart. Peng, C.F., Li, Y.J., Deng, H.W., Xiong, Y. Life Sci. (1996) [Pubmed]

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