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MeSH Review

Ventricular Pressure

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Disease relevance of Ventricular Pressure


High impact information on Ventricular Pressure

  • Despite the fact that glycolytic flux had been blocked both by iodoacetate and by absence of substrate, end-diastolic left ventricular pressure (EDP) remained unchanged (P > 0.15, n = 6) [6].
  • Dobutamine significantly increased the slope of the left ventricular end-systolic pressure-volume relation (Emax) and the slope of the dP/dtmax-end-diastolic volume relation (dE/dtmax), while significantly decreasing the time from end-diastole to end-systole (tmax) and the time constant (T) of the isovolumic fall in left ventricular pressure [7].
  • In 9 of 11 patients there was a substantial downward displacement of the diastolic pressure-volume curve during nitroprusside infusion, with left ventricular pressure being lower for any given volume with nitroprusside [8].
  • In patients with hypertrophic obstructive cardiomyopathy, synchronised and ventricular pacing at optimum AV interval for the individual reduces the intraventricular pressure gradient and improves functional tolerance [9].
  • However, in MCT-treated rats, LU 135252 therapy significantly reduced right ventricular pressure (39.7 +/- 2.1 mm Hg), potentiated acetylcholine-induced vasodilatation (delta Emax, from 1.6 +/- 0.2 to 3.7 +/- 0.4 mm Hg), and improved the responses to sodium nitroprusside (delta Emax, from 2.7 +/- 0.3 to 5.6 +/- 0.6 mm Hg) [10].

Chemical compound and disease context of Ventricular Pressure


Biological context of Ventricular Pressure


Anatomical context of Ventricular Pressure


Associations of Ventricular Pressure with chemical compounds

  • During isoproterenol compared with pacing, peak left ventricular pressure was higher (205 +/- 33 vs. 142 +/- 21 mm Hg, p less than 0.001), ejection fraction was higher (77 +/- 10% vs. 71 +/- 12%, p less than 0.02), and regional systolic nonuniformity was diminished [26].
  • The significant upward shift and attenuation by propranolol were also observed even when the left ventricular pressure was corrected by the subtraction of right atrial pressure [27].
  • Norepinephrine infusion increased systolic left ventricular pressure and SPG, while left ventricular end-diastolic pressure and left atrial pressure diminished [28].
  • We investigated the effects of nifedipine on left ventricular diastolic function in 17 asymptomatic or minimally symptomatic patients with hypertrophic cardiomyopathy by simultaneously measuring left ventricular pressure and volume with a catheter-tipped manometer and biplane cineangiography [29].
  • In 13 patients left ventricular pressure measurements were made with a micromanometer to permit assessment of peak negative dP/dt and the time constant of left ventricular isovolumic relaxation, T, before and after milrinone [30].

Gene context of Ventricular Pressure

  • The increase of isovolumic peak first derivative of left ventricular pressure (ET-1: -2%; molsidomine+ET-1: +16%; BQ 610+ET-1: +19%) after pretreatment with molsidomine or BQ 610 indicates that these drugs unmask the positive inotropy of ET-1 [31].
  • The first derivatives of intraventricular pressure (+/- dP/dt) were also significantly elevated, and this was associated with an increase in the affinity of the SR Ca(2+)-ATPase for Ca2+ in the phospholamban-deficient hearts [32].
  • 3.In the unstimulated perfused heart, the left ventricular pressure (LVP) and maximal rate of left ventricular force development (dP/dtmax) of eNOS-/- hearts were not significantly different from those of WT hearts (LVP: 97 +/- 11 mmHg WT vs. 111 +/- 11 mmHg eNOS-/-; dP/dtmax: 3700 +/- 712 mmHg s(-1) WT vs. 4493 +/- 320 mmHg s)-1) eNOS-/-) [33].
  • In HCM patients, the plasma BNP concentration may reflect the intraventricular pressure gradient and left ventricular diastolic dysfunction whereas the plasma ANP concentration reflects only the left ventricular diastolic dysfunction [34].
  • Balloon inflation to raise ventricular pressure in hearts perfused with cardioplegic solution also activated FAK and ERK1/2 [35].

Analytical, diagnostic and therapeutic context of Ventricular Pressure


  1. Cirrhosis with ascites: increased atrial natriuretic peptide messenger RNA expression in rat ventricle. Poulos, J.E., Gower, W.R., Fontanet, H.L., Kalmus, G.W., Vesely, D.L. Gastroenterology (1995) [Pubmed]
  2. Altered myocardial force-frequency relation in human heart failure. Mulieri, L.A., Hasenfuss, G., Leavitt, B., Allen, P.D., Alpert, N.R. Circulation (1992) [Pubmed]
  3. Long-term angiotensin-converting enzyme inhibition with fosinopril improves depressed responsiveness to Ca2+ in myocytes from aortic-banded rats. Kagaya, Y., Hajjar, R.J., Gwathmey, J.K., Barry, W.H., Lorell, B.H. Circulation (1996) [Pubmed]
  4. Mitochondrial response to heart rate steps in isolated rabbit heart is slowed after myocardial stunning. Zuurbier, C.J., van Beek, J.H. Circ. Res. (1997) [Pubmed]
  5. Effects of beta-blockade and atropine on ischemic responses in left ventricular regions subtending coronary stenosis during dobutamine stress echocardiography. Chen, L., Ma, L., de Prada, V.A., Chen, M., Feng, Y.J., Waters, D., Gillam, L., Chen, C. J. Am. Coll. Cardiol. (1996) [Pubmed]
  6. Mechanism of the diastolic dysfunction induced by glycolytic inhibition. Does adenosine triphosphate derived from glycolysis play a favored role in cellular Ca2+ homeostasis in ferret myocardium? Kusuoka, H., Marban, E. J. Clin. Invest. (1994) [Pubmed]
  7. Comparison of effects of dobutamine and ouabain on left ventricular contraction and relaxation in closed-chest dogs. Little, W.C., Rassi, A., Freeman, G.L. J. Clin. Invest. (1987) [Pubmed]
  8. Effects of sodium nitroprusside on left ventricular diastolic pressure-volume relations. Brodie, B.R., Grossman, W., Mann, T., McLaurin, L.P. J. Clin. Invest. (1977) [Pubmed]
  9. Effects of dual-chamber pacing in hypertrophic obstructive cardiomyopathy. Jeanrenaud, X., Goy, J.J., Kappenberger, L. Lancet (1992) [Pubmed]
  10. EndothelinA receptor blockade improves nitric oxide-mediated vasodilation in monocrotaline-induced pulmonary hypertension. Prié, S., Stewart, D.J., Dupuis, J. Circulation (1998) [Pubmed]
  11. Effect of a single oral dose of milrinone on left ventricular diastolic performance in the failing human heart. Piscione, F., Jaski, B.E., Wenting, G.J., Serruys, P.W. J. Am. Coll. Cardiol. (1987) [Pubmed]
  12. Nitrate therapy for ischaemic heart disease. Conti, C.R. Eur. Heart J. (1985) [Pubmed]
  13. Collagen deposition and the reversal of coronary reserve in cardiac hypertrophy. Isoyama, S., Ito, N., Satoh, K., Takishima, T. Hypertension (1992) [Pubmed]
  14. Regulation of extracellular matrix proteins in pressure-overload cardiac hypertrophy: effects of angiotensin converting enzyme inhibition. Grimm, D., Kromer, E.P., Böcker, W., Bruckschlegel, G., Holmer, S.R., Riegger, G.A., Schunkert, H. J. Hypertens. (1998) [Pubmed]
  15. Reduction by oral propranolol treatment of left ventricular hypertrophy secondary to pressure-overload in the rat. Ostman-Smith, I. Br. J. Pharmacol. (1995) [Pubmed]
  16. Nifedipine protects the heart from the acute deleterious effects of cocaine if administered before but not after cocaine. Hale, S.L., Alker, K.J., Rezkalla, S.H., Eisenhauer, A.C., Kloner, R.A. Circulation (1991) [Pubmed]
  17. Alterations in calcium levels of coronary sinus blood during coronary arteriography in the dog. Higgins, C.B., Schmidt, W. Circulation (1978) [Pubmed]
  18. Influence of beta-adrenergic stimulation and contraction frequency on rat heart interstitial adenosine. Fenton, R.A., Tsimikas, S., Dobson, J.G. Circ. Res. (1990) [Pubmed]
  19. Adenosine release by the isolated guinea pig heart in response to isoproterenol, acetylcholine, and acidosis: the minimal role of vascular endothelium. Bardenheuer, H., Whelton, B., Sparks, H.V. Circ. Res. (1987) [Pubmed]
  20. Effect of digitalis on left ventricular function in exercising dogs. Horwitz, L.D., Atkins, J.M., Saito, M. Circ. Res. (1977) [Pubmed]
  21. Noninvasive assessment of the ventricular relaxation time constant (tau) in humans by Doppler echocardiography. Scalia, G.M., Greenberg, N.L., McCarthy, P.M., Thomas, J.D., Vandervoort, P.M. Circulation (1997) [Pubmed]
  22. Increased regional myocardial stiffness of the left ventricle during pacing-induced angina in man. Bourdillon, P.D., Lorell, B.H., Mirsky, I., Paulus, W.J., Wynne, J., Grossman, W. Circulation (1983) [Pubmed]
  23. Alpha-adrenergic-mediated reduction in coronary blood flow secondary to carotid chemoreceptor reflex activation in conscious dogs. Murray, P.A., Lavallee, M., Vatner, S.F. Circ. Res. (1984) [Pubmed]
  24. Doppler echocardiographic demonstration of the differential effects of right ventricular pressure and volume overload on left ventricular geometry and filling. Louie, E.K., Rich, S., Levitsky, S., Brundage, B.H. J. Am. Coll. Cardiol. (1992) [Pubmed]
  25. Effect of glucocorticoids on collagen accumulation in pulmonary vascular remodeling in the rat. Poiani, G.J., Tozzi, C.A., Thakker-Varia, S., Choe, J.K., Riley, D.J. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  26. Beta-adrenergic stimulation with isoproterenol enhances left ventricular diastolic performance in hypertrophic cardiomyopathy despite potentiation of myocardial ischemia. Comparison to rapid atrial pacing. Udelson, J.E., Cannon, R.O., Bacharach, S.L., Rumble, T.F., Bonow, R.O. Circulation (1989) [Pubmed]
  27. Exercise-induced upward shift of diastolic left ventricular pressure-volume relation in patients with dilated cardiomyopathy. Effects of beta-adrenoceptor blockade. Sato, H., Hori, M., Ozaki, H., Yokoyama, H., Imai, K., Morikawa, M., Takeda, H., Inoue, M., Kamada, T. Circulation (1993) [Pubmed]
  28. Dynamic aspects of acute mitral regurgitation: effects of ventricular volume, pressure and contractility on the effective regurgitant orifice area. Yoran, C., Yellin, E.L., Becker, R.M., Gabbay, S., Frater, R.W., Sonnenblick, E.H. Circulation (1979) [Pubmed]
  29. Effects of nifedipine on left ventricular diastolic function in patients with asymptomatic or minimally symptomatic hypertrophic cardiomyopathy. Yamakado, T., Okano, H., Higashiyama, S., Hamada, M., Nakano, T., Takezawa, H. Circulation (1990) [Pubmed]
  30. Improvement in indexes of diastolic performance in patients with congestive heart failure treated with milrinone. Monrad, E.S., McKay, R.G., Baim, D.S., Colucci, W.S., Fifer, M.A., Heller, G.V., Royal, H.D., Grossman, W. Circulation (1984) [Pubmed]
  31. Inotropic effects of endothelin-1: interaction with molsidomine and with BQ 610. Beyer, M.E., Slesak, G., Hövelborn, T., Kazmaier, S., Nerz, S., Hoffmeister, H.M. Hypertension (1999) [Pubmed]
  32. Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation. Luo, W., Grupp, I.L., Harrer, J., Ponniah, S., Grupp, G., Duffy, J.J., Doetschman, T., Kranias, E.G. Circ. Res. (1994) [Pubmed]
  33. Inotropic response to beta-adrenergic receptor stimulation and anti-adrenergic effect of ACh in endothelial NO synthase-deficient mouse hearts. Gödecke, A., Heinicke, T., Kamkin, A., Kiseleva, I., Strasser, R.H., Decking, U.K., Stumpe, T., Isenberg, G., Schrader, J. J. Physiol. (Lond.) (2001) [Pubmed]
  34. Neurohumoral profiles in patients with hypertrophic cardiomyopathy: differences to hypertensive left ventricular hypertrophy. Ogino, K., Ogura, K., Kinugawa, T., Osaki, S., Kato, M., Furuse, Y., Kinugasa, Y., Tomikura, Y., Igawa, O., Hisatome, I., Shigemasa, C. Circ. J. (2004) [Pubmed]
  35. Load-induced focal adhesion kinase activation in the myocardium: role of stretch and contractile activity. Domingos, P.P., Fonseca, P.M., Nadruz, W., Franchini, K.G. Am. J. Physiol. Heart Circ. Physiol. (2002) [Pubmed]
  36. Modification of abnormal left ventricular diastolic properties by nifedipine in patients with hypertrophic cardiomyopathy. Lorell, B.H., Paulus, W.J., Grossman, W., Wynne, J., Cohn, P.F. Circulation (1982) [Pubmed]
  37. Mechanism of adenosine inhibition of catecholamine-induced responses in heart. Dobson, J.G. Circ. Res. (1983) [Pubmed]
  38. Increased [18F]fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol. Oikawa, M., Kagaya, Y., Otani, H., Sakuma, M., Demachi, J., Suzuki, J., Takahashi, T., Nawata, J., Ido, T., Watanabe, J., Shirato, K. J. Am. Coll. Cardiol. (2005) [Pubmed]
  39. Effect of nicorandil on left ventricular end-diastolic pressure during exercise in patients with hypertrophic cardiomyopathy. Izawa, H., Iwase, M., Takeichi, Y., Somura, F., Nagata, K., Nishizawa, T., Noda, A., Murohara, T., Yokota, M. Eur. Heart J. (2003) [Pubmed]
  40. Effects of glibenclamide on ventricular arrhythmias and cardiac function in ischaemia and reperfusion in isolated rat heart. Bril, A., Laville, M.P., Gout, B. Cardiovasc. Res. (1992) [Pubmed]
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