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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Smooth muscle alpha-actin expression in rat hepatic stellate cell is regulated by nitric oxide and cGMP production.

Mechanism by which lipopolysaccharide (LPS) and interferon gamma (IFN gamma) downregulate smooth muscle (SM) alpha-actin expression in rat hepatic stellate cell was studied. Culture-induced SM alpha-actin expression was suppressed in the presence of LPS (> 5 ng/ml) and/or IFN gamma (> 1 U/ml) dose-dependently. Inhibition of nitric oxide (NO) production by N omega-nitro-L-arginine (LNA) canceled such an inhibitory effect of LPS and/or IFN gamma. LPS and/or IFN gamma increased cellular level of cGMP in an LNA inhibitable manner, and cGMP analogues attenuated SM alpha-actin expression of the cells. These results indicate that NO-dependent increase of cellular cGMP level mediates the inhibitory effect of LPS and IFN gamma on SM alpha-actin expression in stellate cells.[1]

References

  1. Smooth muscle alpha-actin expression in rat hepatic stellate cell is regulated by nitric oxide and cGMP production. Kawada, N., Kuroki, T., Uoya, M., Inoue, M., Kobayashi, K. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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