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Gene Review

Acta2  -  actin, alpha 2, smooth muscle, aorta

Rattus norvegicus

Synonyms: Actin, aortic smooth muscle, Actsa, Actvs, Alpha-actin-2
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Disease relevance of Acta2


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Chemical compound and disease context of Acta2


Biological context of Acta2


Anatomical context of Acta2


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Regulatory relationships of Acta2


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Analytical, diagnostic and therapeutic context of Acta2


  1. The vascular smooth muscle alpha-actin gene is reactivated during cardiac hypertrophy provoked by load. Black, F.M., Packer, S.E., Parker, T.G., Michael, L.H., Roberts, R., Schwartz, R.J., Schneider, M.D. J. Clin. Invest. (1991) [Pubmed]
  2. Inhibitory effect of tranilast on activation and transforming growth factor beta 1 expression in cultured rat stellate cells. Ikeda, H., Inao, M., Fujiwara, K. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  3. The induction of smooth muscle alpha actin in a transformed rat cell line suppresses malignant properties in vitro and in vivo. Okamoto-Inoue, M., Kamada, S., Kimura, G., Taniguchi, S. Cancer Lett. (1999) [Pubmed]
  4. Human malignant melanoma cells release a factor that inhibits the expression of smooth muscle alpha-actin. Okamoto-Inoue, M., Nakayama, J., Hori, Y., Taniguchi, S. J. Dermatol. Sci. (2000) [Pubmed]
  5. Endothelin antagonism in experimental hepatic fibrosis. Implications for endothelin in the pathogenesis of wound healing. Rockey, D.C., Chung, J.J. J. Clin. Invest. (1996) [Pubmed]
  6. Activation-dependent contractility of rat hepatic lipocytes in culture and in vivo. Rockey, D.C., Housset, C.N., Friedman, S.L. J. Clin. Invest. (1993) [Pubmed]
  7. Class VI intermediate filament protein nestin is induced during activation of rat hepatic stellate cells. Niki, T., Pekny, M., Hellemans, K., Bleser, P.D., Berg, K.V., Vaeyens, F., Quartier, E., Schuit, F., Geerts, A. Hepatology (1999) [Pubmed]
  8. Galpha16 mimics vasoconstrictor action to induce smooth muscle alpha-actin in vascular smooth muscle cells through a Jun-NH2-terminal kinase-dependent pathway. Higashita, R., Li, L., Van Putten, V., Yamamura, Y., Zarinetchi, F., Heasley, L., Nemenoff, R.A. J. Biol. Chem. (1997) [Pubmed]
  9. Therapeutic significance of Y-27632, a Rho-kinase inhibitor, on the established liver fibrosis. Murata, T., Arii, S., Mori, A., Imamura, M. J. Surg. Res. (2003) [Pubmed]
  10. Expression and localization of alpha-smooth muscle and gamma-actins in the pregnant rat myometrium. Shynlova, O., Tsui, P., Dorogin, A., Chow, M., Lye, S.J. Biol. Reprod. (2005) [Pubmed]
  11. Peptide growth factors can provoke "fetal" contractile protein gene expression in rat cardiac myocytes. Parker, T.G., Packer, S.E., Schneider, M.D. J. Clin. Invest. (1990) [Pubmed]
  12. The nucleotide sequence of a rat vascular smooth muscle alpha-actin cDNA. McHugh, K.M., Lessard, J.L. Nucleic Acids Res. (1988) [Pubmed]
  13. Evidence for the presence of smooth muscle alpha-actin within pericytes of the renal medulla. Park, F., Mattson, D.L., Roberts, L.A., Cowley, A.W. Am. J. Physiol. (1997) [Pubmed]
  14. Cell cycle versus density dependence of smooth muscle alpha actin expression in cultured rat aortic smooth muscle cells. Blank, R.S., Thompson, M.M., Owens, G.K. J. Cell Biol. (1988) [Pubmed]
  15. Mechanisms of angiotensin II- and arginine vasopressin-induced increases in protein synthesis and content in cultured rat aortic smooth muscle cells. Evidence for selective increases in smooth muscle isoactin expression. Turla, M.B., Thompson, M.M., Corjay, M.H., Owens, G.K. Circ. Res. (1991) [Pubmed]
  16. Angiotensin II-induced stimulation of smooth muscle alpha-actin expression by serum response factor and the homeodomain transcription factor MHox. Hautmann, M.B., Thompson, M.M., Swartz, E.A., Olson, E.N., Owens, G.K. Circ. Res. (1997) [Pubmed]
  17. Retinoic acid and transforming growth factor beta differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation. Davis, B.H., Rapp, U.R., Davidson, N.O. Biochem. J. (1991) [Pubmed]
  18. Endothelin-1 and isoprenaline co-stimulation causes contractile failure which is partially reversed by MEK inhibition. Münzel, F., Mühlhäuser, U., Zimmermann, W.H., Didié, M., Schneiderbanger, K., Schubert, P., Engmann, S., Eschenhagen, T., Zolk, O. Cardiovasc. Res. (2005) [Pubmed]
  19. Regulation of smooth muscle alpha-actin promoter by vasopressin and platelet-derived growth factor in rat aortic vascular smooth muscle cells. Van Putten, V., Li, X., Maselli, J., Nemenoff, R.A. Circ. Res. (1994) [Pubmed]
  20. Vascular repair processes mediated by transforming growth factor-beta. Lindner, V. Zeitschrift für Kardiologie. (2001) [Pubmed]
  21. Elastin expression in a model of acute arterial graft rejection. Isik, F.F., Clowes, A.W., Gordon, D. Transplantation (1994) [Pubmed]
  22. Insulin-like growth factor I stimulates myofibril development and decreases smooth muscle alpha-actin of adult cardiomyocytes. Donath, M.Y., Zapf, J., Eppenberger-Eberhardt, M., Froesch, E.R., Eppenberger, H.M. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  23. Induction of smooth muscle alpha-actin in vascular smooth muscle cells by arginine vasopressin is mediated by c-Jun amino-terminal kinases and p38 mitogen-activated protein kinase. Garat, C., Van Putten, V., Refaat, Z.A., Dessev, C., Han, S.Y., Nemenoff, R.A. J. Biol. Chem. (2000) [Pubmed]
  24. Similarities and differences in smooth muscle alpha-actin induction by TGF-beta in smooth muscle versus non-smooth muscle cells. Hautmann, M.B., Adam, P.J., Owens, G.K. Arterioscler. Thromb. Vasc. Biol. (1999) [Pubmed]
  25. Dedifferentiation of stromal smooth muscle as a factor in prostate carcinogenesis. Wong, Y.C., Tam, N.N. Differentiation (2002) [Pubmed]
  26. Actin is a surface component of calf pulmonary artery endothelial cells in culture. Moroianu, J., Fett, J.W., Riordan, J.F., Vallee, B.L. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  27. Epithelial re-growth is associated with inhibition of obliterative airway disease in orthotopic tracheal allografts in non-immunosuppressed rats. Ikonen, T.S., Brazelton, T.R., Berry, G.J., Shorthouse, R.S., Morris, R.E. Transplantation (2000) [Pubmed]
  28. Apoptosis in dissociation between DNA synthesis and cellular functions of activated hepatic stellate cells--a study with carbon tetrachloride-induced rat liver injury. Osada, N., Mochida, S., Inao, M., Mashimo, Y., Fujiwara, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
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